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Dietary calcium intake and risk of type 2 diabetes: possible confounding by magnesium.
Eur J Clin Nutr 2012; 66(3):408-10EJ

Abstract

This study examined the association of dietary calcium intake with incident type 2 diabetes by a meta-analysis and explored the potential confounding by magnesium. Potential studies were identified by searching the PubMed database in September 2011. Prospective cohort studies that reported relative risks (RR) with 95% confidence intervals (CI) of type 2 diabetes for dietary calcium intake were selected. Results were combined using either a fixed- or random-effects model. Six prospective cohort studies comprising 264268 participants and 11225 reported cases were included. All combined random-effects meta-analysis yielded a significant pooled RR of 0.85 (95% CI 0.75-0.97). However, a sensitivity analysis limited to four studies with control for magnesium yielded an attenuated, nonsignificant pooled RR of 0.94 (95% CI 0.85-1.05). In conclusion, dietary calcium intake was not independently associated with risk of type 2 diabetes. The inverse association in prior observational studies may be partially confounded by magnesium intake.

Authors+Show Affiliations

Department of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, China.No affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

22318650

Citation

Dong, J-Y, and L-Q Qin. "Dietary Calcium Intake and Risk of Type 2 Diabetes: Possible Confounding By Magnesium." European Journal of Clinical Nutrition, vol. 66, no. 3, 2012, pp. 408-10.
Dong JY, Qin LQ. Dietary calcium intake and risk of type 2 diabetes: possible confounding by magnesium. Eur J Clin Nutr. 2012;66(3):408-10.
Dong, J. Y., & Qin, L. Q. (2012). Dietary calcium intake and risk of type 2 diabetes: possible confounding by magnesium. European Journal of Clinical Nutrition, 66(3), pp. 408-10. doi:10.1038/ejcn.2012.5.
Dong JY, Qin LQ. Dietary Calcium Intake and Risk of Type 2 Diabetes: Possible Confounding By Magnesium. Eur J Clin Nutr. 2012;66(3):408-10. PubMed PMID: 22318650.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary calcium intake and risk of type 2 diabetes: possible confounding by magnesium. AU - Dong,J-Y, AU - Qin,L-Q, Y1 - 2012/02/08/ PY - 2012/2/10/entrez PY - 2012/2/10/pubmed PY - 2012/7/28/medline SP - 408 EP - 10 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 66 IS - 3 N2 - This study examined the association of dietary calcium intake with incident type 2 diabetes by a meta-analysis and explored the potential confounding by magnesium. Potential studies were identified by searching the PubMed database in September 2011. Prospective cohort studies that reported relative risks (RR) with 95% confidence intervals (CI) of type 2 diabetes for dietary calcium intake were selected. Results were combined using either a fixed- or random-effects model. Six prospective cohort studies comprising 264268 participants and 11225 reported cases were included. All combined random-effects meta-analysis yielded a significant pooled RR of 0.85 (95% CI 0.75-0.97). However, a sensitivity analysis limited to four studies with control for magnesium yielded an attenuated, nonsignificant pooled RR of 0.94 (95% CI 0.85-1.05). In conclusion, dietary calcium intake was not independently associated with risk of type 2 diabetes. The inverse association in prior observational studies may be partially confounded by magnesium intake. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/22318650/Dietary_calcium_intake_and_risk_of_type_2_diabetes:_possible_confounding_by_magnesium_ L2 - http://dx.doi.org/10.1038/ejcn.2012.5 DB - PRIME DP - Unbound Medicine ER -