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[The significance of autoantibodies coexisting with anti-centromere antibodies in sera of patients with primary biliary cirrhosis].
Rinsho Byori 1990; 38(8):888-94RB

Abstract

Anti-centromere antibody (ACA) has been believed to be specific to patients with CREST syndrome, a variant of scleroderma (PSS). This study was undertaken to clarify the distribution of ACA in various diseases and the significance of autoantibodies coexisting with it. The sera of patients with primary biliary cirrhosis (PBC) along with collagen diseases and aged subjects were examined for ACA by immunofluorescence method (IF) using cultured HEp-2 cells and chromosomes prepared from K 562 cells. ACA were found in sera of 10 patients with PBC, one with scleroderma, one with cerebral infarction and one with chronic renal failure respectively. ACA positive sera were examined for antibodies against other nuclear antigens including nRNP, Sm, Scl-70, SS-A and SS-B and cytoplasmic antigens by double immunodiffusion methods using rabbit thymus extract etc. as the antigens and by IF method using cryostat sections of rat kidney and stomach. In 13 sera with ACA, antimitochondrial antibody (AMA), anti-smooth muscle antibody (ASMA) and anti SS-A antibody were found in 10, 4 and one sera respectively. In 10 PBC patients with ACA, various collagen disease-related disorders were found to coexist; CREST syndrome in one, CRST syndrome in one, Raynaud's phenomenon in two and Sjögren's syndrome in 5. These results would indicate that ACA may be one of the common serological abnormalities among patients with PBC, CREST syndrome and Sjögren's syndrome.

Authors+Show Affiliations

Central Clinical Laboratories, Fukushima Medical College.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

jpn

PubMed ID

2232249

Citation

Moteki, S, et al. "[The Significance of Autoantibodies Coexisting With Anti-centromere Antibodies in Sera of Patients With Primary Biliary Cirrhosis]." Rinsho Byori. the Japanese Journal of Clinical Pathology, vol. 38, no. 8, 1990, pp. 888-94.
Moteki S, Yoshida H, Nishimaki T, et al. [The significance of autoantibodies coexisting with anti-centromere antibodies in sera of patients with primary biliary cirrhosis]. Rinsho Byori. 1990;38(8):888-94.
Moteki, S., Yoshida, H., Nishimaki, T., & Morito, T. (1990). [The significance of autoantibodies coexisting with anti-centromere antibodies in sera of patients with primary biliary cirrhosis]. Rinsho Byori. the Japanese Journal of Clinical Pathology, 38(8), pp. 888-94.
Moteki S, et al. [The Significance of Autoantibodies Coexisting With Anti-centromere Antibodies in Sera of Patients With Primary Biliary Cirrhosis]. Rinsho Byori. 1990;38(8):888-94. PubMed PMID: 2232249.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The significance of autoantibodies coexisting with anti-centromere antibodies in sera of patients with primary biliary cirrhosis]. AU - Moteki,S, AU - Yoshida,H, AU - Nishimaki,T, AU - Morito,T, PY - 1990/8/1/pubmed PY - 1990/8/1/medline PY - 1990/8/1/entrez SP - 888 EP - 94 JF - Rinsho byori. The Japanese journal of clinical pathology JO - Rinsho Byori VL - 38 IS - 8 N2 - Anti-centromere antibody (ACA) has been believed to be specific to patients with CREST syndrome, a variant of scleroderma (PSS). This study was undertaken to clarify the distribution of ACA in various diseases and the significance of autoantibodies coexisting with it. The sera of patients with primary biliary cirrhosis (PBC) along with collagen diseases and aged subjects were examined for ACA by immunofluorescence method (IF) using cultured HEp-2 cells and chromosomes prepared from K 562 cells. ACA were found in sera of 10 patients with PBC, one with scleroderma, one with cerebral infarction and one with chronic renal failure respectively. ACA positive sera were examined for antibodies against other nuclear antigens including nRNP, Sm, Scl-70, SS-A and SS-B and cytoplasmic antigens by double immunodiffusion methods using rabbit thymus extract etc. as the antigens and by IF method using cryostat sections of rat kidney and stomach. In 13 sera with ACA, antimitochondrial antibody (AMA), anti-smooth muscle antibody (ASMA) and anti SS-A antibody were found in 10, 4 and one sera respectively. In 10 PBC patients with ACA, various collagen disease-related disorders were found to coexist; CREST syndrome in one, CRST syndrome in one, Raynaud's phenomenon in two and Sjögren's syndrome in 5. These results would indicate that ACA may be one of the common serological abnormalities among patients with PBC, CREST syndrome and Sjögren's syndrome. SN - 0047-1860 UR - https://www.unboundmedicine.com/medline/citation/2232249/[The_significance_of_autoantibodies_coexisting_with_anti_centromere_antibodies_in_sera_of_patients_with_primary_biliary_cirrhosis]_ L2 - http://www.diseaseinfosearch.org/result/5940 DB - PRIME DP - Unbound Medicine ER -