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Waist circumference and metabolic syndrome: the risk for silent coronary artery disease in males.
Metab Syndr Relat Disord. 2012 Jun; 10(3):225-31.MS

Abstract

BACKGROUND

Waist circumference (WC) is a component used to define metabolic syndrome. However, its role as an independent predictor of silent coronary artery disease (CAD), above its contribution to metabolic syndrome, remains unknown.

METHODS

Male veterans without known CAD, undergoing cardiac stress testing for indications other than typical angina or its equivalent, were evaluated for the presence of silent CAD. High WC and metabolic syndrome were defined per the revised National Cholesterol Education Program (NCEP-R) and the International Diabetes Federation (IDF) criteria.

RESULTS

Data on 1,071 patients (age 61±11 years) were analyzed retrospectively. On multivariable logistic regression analysis [odds ratio (OR), 95% confidence interval (CI), P value), a WC ≥94 cm (1.42, 1.04-1.93; P=0.026), metabolic syndrome by NCEP-R (1.73, 1.29-2.33; P<0.0001), and metabolic syndrome by IDF (1.57, 1.17-2.11; P=0.003) were independent predictors of silent CAD. When comparing patients meeting criteria for metabolic syndrome defined by either NCEP-R or IDF, the prevalence of silent CAD was not statistically different (P=0.86). The prevalence of silent CAD associated with a high WC was not inferior to that seen between silent CAD and metabolic syndrome as defined by either criterion. Last, among patients with metabolic syndrome defined by NCEP-R, those with a high WC as a defining component of metabolic syndrome had a higher prevalence of silent CAD (30% vs. 20%; P=0.026).

CONCLUSION

A WC ≥94 cm in males is independently associated with an increased prevalence of silent CAD. In patients with metabolic syndrome, this prevalence is increased by the presence of high WC.

Authors+Show Affiliations

Department of Internal Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22324791

Citation

Vakil, Kairav P., et al. "Waist Circumference and Metabolic Syndrome: the Risk for Silent Coronary Artery Disease in Males." Metabolic Syndrome and Related Disorders, vol. 10, no. 3, 2012, pp. 225-31.
Vakil KP, Malhotra S, Sawada S, et al. Waist circumference and metabolic syndrome: the risk for silent coronary artery disease in males. Metab Syndr Relat Disord. 2012;10(3):225-31.
Vakil, K. P., Malhotra, S., Sawada, S., Campbell, S. R., Sayfo, S., & Kamalesh, M. (2012). Waist circumference and metabolic syndrome: the risk for silent coronary artery disease in males. Metabolic Syndrome and Related Disorders, 10(3), 225-31. https://doi.org/10.1089/met.2011.0099
Vakil KP, et al. Waist Circumference and Metabolic Syndrome: the Risk for Silent Coronary Artery Disease in Males. Metab Syndr Relat Disord. 2012;10(3):225-31. PubMed PMID: 22324791.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Waist circumference and metabolic syndrome: the risk for silent coronary artery disease in males. AU - Vakil,Kairav P, AU - Malhotra,Saurabh, AU - Sawada,Stephen, AU - Campbell,Steffanie R, AU - Sayfo,Sameh, AU - Kamalesh,Masoor, Y1 - 2012/02/10/ PY - 2012/2/14/entrez PY - 2012/2/14/pubmed PY - 2012/10/4/medline SP - 225 EP - 31 JF - Metabolic syndrome and related disorders JO - Metab Syndr Relat Disord VL - 10 IS - 3 N2 - BACKGROUND: Waist circumference (WC) is a component used to define metabolic syndrome. However, its role as an independent predictor of silent coronary artery disease (CAD), above its contribution to metabolic syndrome, remains unknown. METHODS: Male veterans without known CAD, undergoing cardiac stress testing for indications other than typical angina or its equivalent, were evaluated for the presence of silent CAD. High WC and metabolic syndrome were defined per the revised National Cholesterol Education Program (NCEP-R) and the International Diabetes Federation (IDF) criteria. RESULTS: Data on 1,071 patients (age 61±11 years) were analyzed retrospectively. On multivariable logistic regression analysis [odds ratio (OR), 95% confidence interval (CI), P value), a WC ≥94 cm (1.42, 1.04-1.93; P=0.026), metabolic syndrome by NCEP-R (1.73, 1.29-2.33; P<0.0001), and metabolic syndrome by IDF (1.57, 1.17-2.11; P=0.003) were independent predictors of silent CAD. When comparing patients meeting criteria for metabolic syndrome defined by either NCEP-R or IDF, the prevalence of silent CAD was not statistically different (P=0.86). The prevalence of silent CAD associated with a high WC was not inferior to that seen between silent CAD and metabolic syndrome as defined by either criterion. Last, among patients with metabolic syndrome defined by NCEP-R, those with a high WC as a defining component of metabolic syndrome had a higher prevalence of silent CAD (30% vs. 20%; P=0.026). CONCLUSION: A WC ≥94 cm in males is independently associated with an increased prevalence of silent CAD. In patients with metabolic syndrome, this prevalence is increased by the presence of high WC. SN - 1557-8518 UR - https://www.unboundmedicine.com/medline/citation/22324791/Waist_circumference_and_metabolic_syndrome:_the_risk_for_silent_coronary_artery_disease_in_males_ L2 - https://www.liebertpub.com/doi/10.1089/met.2011.0099?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -