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Diacerein as adjuvant to diclofenac sodium in osteoarthritis knee.
Int J Rheum Dis. 2012 Feb; 15(1):69-77.IJ

Abstract

AIM

To evaluate clinical effectiveness of diacerein as an adjuvant to diclofenac sodium in treatment of Indian patients with symptomatic osteoarthritis (OA) knee.

METHODS

This is a prospective, double-blind, placebo-controlled and intention-to-treat study. An initial washout period of 1 week, was followed by 3 months treatment period during which patients were randomly divided to receive either capsule diacerein 50 mg or matched placebo once daily for the first month and twice daily for the next 2 months with diclofenac sodium 75 mg sustained release tablet once daily given to both groups. Patients were observed for one more month, using paracetamol as rescue therapy. Treatment efficacy was assessed by a visual analogue scale (VAS) and the Western Ontario and McMaster University (WOMAC) Osteoarthritis Index, patient and physician global assessment of OA, daily paracetamol intake.

RESULTS

Of 84 patients screened, 74 patients formed the intent-to-treat population (37 patients in each group). At baseline, both groups were comparable and at the third month functional index and pain intensity were better in the diacerein group (VAS 15.33 ± 5.07; WOMAC 15.9 ± 2.40) as compared to the placebo group (VAS 22.83 ± 6.90;WOMAC 36.8 ± 2.92; P < 0.05). When analyzed at the fourth month, improvement persisted in the iacerein group (VAS 14.83 ± 5.16; WOMAC 16 ± 2.5) as compared to placebo group (VAS 33 ± 7.72; WOMAC 48.26 ± 3.5; P < 0.05), demonstrating the carry-over effect of diacerein, which was confirmed by lesser paracetamol consumption in the diacerein group (5.967 ± 0.8087) as compared to the placebo group (12.433 ± 2.128; P < 0.05).

CONCLUSION

Use of diacerein and diclofenac sodium together decreases pain and improves joint function significantly more than diclofenac alone in OA knee.

Authors+Show Affiliations

Department of Pharmacology, Government Medical College, Amritsar, India. drkuljindersingh@gmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

22324949

Citation

Singh, Kuljinder, et al. "Diacerein as Adjuvant to Diclofenac Sodium in Osteoarthritis Knee." International Journal of Rheumatic Diseases, vol. 15, no. 1, 2012, pp. 69-77.
Singh K, Sharma R, Rai J. Diacerein as adjuvant to diclofenac sodium in osteoarthritis knee. Int J Rheum Dis. 2012;15(1):69-77.
Singh, K., Sharma, R., & Rai, J. (2012). Diacerein as adjuvant to diclofenac sodium in osteoarthritis knee. International Journal of Rheumatic Diseases, 15(1), 69-77. https://doi.org/10.1111/j.1756-185X.2011.01648.x
Singh K, Sharma R, Rai J. Diacerein as Adjuvant to Diclofenac Sodium in Osteoarthritis Knee. Int J Rheum Dis. 2012;15(1):69-77. PubMed PMID: 22324949.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diacerein as adjuvant to diclofenac sodium in osteoarthritis knee. AU - Singh,Kuljinder, AU - Sharma,Rakesh, AU - Rai,Jaswant, Y1 - 2011/09/06/ PY - 2012/2/14/entrez PY - 2012/2/14/pubmed PY - 2012/6/23/medline SP - 69 EP - 77 JF - International journal of rheumatic diseases JO - Int J Rheum Dis VL - 15 IS - 1 N2 - AIM: To evaluate clinical effectiveness of diacerein as an adjuvant to diclofenac sodium in treatment of Indian patients with symptomatic osteoarthritis (OA) knee. METHODS: This is a prospective, double-blind, placebo-controlled and intention-to-treat study. An initial washout period of 1 week, was followed by 3 months treatment period during which patients were randomly divided to receive either capsule diacerein 50 mg or matched placebo once daily for the first month and twice daily for the next 2 months with diclofenac sodium 75 mg sustained release tablet once daily given to both groups. Patients were observed for one more month, using paracetamol as rescue therapy. Treatment efficacy was assessed by a visual analogue scale (VAS) and the Western Ontario and McMaster University (WOMAC) Osteoarthritis Index, patient and physician global assessment of OA, daily paracetamol intake. RESULTS: Of 84 patients screened, 74 patients formed the intent-to-treat population (37 patients in each group). At baseline, both groups were comparable and at the third month functional index and pain intensity were better in the diacerein group (VAS 15.33 ± 5.07; WOMAC 15.9 ± 2.40) as compared to the placebo group (VAS 22.83 ± 6.90;WOMAC 36.8 ± 2.92; P < 0.05). When analyzed at the fourth month, improvement persisted in the iacerein group (VAS 14.83 ± 5.16; WOMAC 16 ± 2.5) as compared to placebo group (VAS 33 ± 7.72; WOMAC 48.26 ± 3.5; P < 0.05), demonstrating the carry-over effect of diacerein, which was confirmed by lesser paracetamol consumption in the diacerein group (5.967 ± 0.8087) as compared to the placebo group (12.433 ± 2.128; P < 0.05). CONCLUSION: Use of diacerein and diclofenac sodium together decreases pain and improves joint function significantly more than diclofenac alone in OA knee. SN - 1756-185X UR - https://www.unboundmedicine.com/medline/citation/22324949/Diacerein_as_adjuvant_to_diclofenac_sodium_in_osteoarthritis_knee_ L2 - https://doi.org/10.1111/j.1756-185X.2011.01648.x DB - PRIME DP - Unbound Medicine ER -