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Effects of depression and anxiety improvement on adherence to medication and health behaviors in recently hospitalized cardiac patients.
Am J Cardiol. 2012 May 01; 109(9):1266-71.AJ

Abstract

Impaired adherence to medications and health behaviors may mediate the connection between psychiatric symptoms and mortality in cardiac patients. This study assessed the association between improvements in depression/anxiety and self-reported adherence to health behaviors in depressed cardiac patients in the 6 months after cardiac hospitalization. Data were analyzed from depressed patients on inpatient cardiac units who were hospitalized for acute coronary syndrome, heart failure, or arrhythmia and enrolled in a randomized trial of collaborative care depression management (n = 134 in primary analysis). Measurements of depression (Patient Health Questionnaire-9), anxiety (Hospital Anxiety and Depression Scale, Anxiety subscale), and adherence to secondary prevention behaviors (Medical Outcomes Study-Specific Adherence Scale items) were obtained at baseline, 6 weeks 12 weeks, and 6 months. The association between improvement in depression/anxiety and adherence was assessed by linear regression after accounting for the effects of multiple relevant covariates. At all time points improvement in the Patient Health Questionnaire-9 was significantly and independently associated with self-reported adherence to medications and secondary prevention behaviors. In contrast, improvement in the Hospital Anxiety and Depression Scale, Anxiety subscale was associated with improved adherence only at 6 weeks. In conclusion, in a cohort of depressed cardiac patients, improvement in depression was consistently and independently associated with superior self-reported adherence to medications and secondary prevention behaviors across a 6-month span, whereas improvement in anxiety was not.

Authors+Show Affiliations

Harvard Medical School, Boston, Massachusetts, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22325974

Citation

Bauer, Leah K., et al. "Effects of Depression and Anxiety Improvement On Adherence to Medication and Health Behaviors in Recently Hospitalized Cardiac Patients." The American Journal of Cardiology, vol. 109, no. 9, 2012, pp. 1266-71.
Bauer LK, Caro MA, Beach SR, et al. Effects of depression and anxiety improvement on adherence to medication and health behaviors in recently hospitalized cardiac patients. Am J Cardiol. 2012;109(9):1266-71.
Bauer, L. K., Caro, M. A., Beach, S. R., Mastromauro, C. A., Lenihan, E., Januzzi, J. L., & Huffman, J. C. (2012). Effects of depression and anxiety improvement on adherence to medication and health behaviors in recently hospitalized cardiac patients. The American Journal of Cardiology, 109(9), 1266-71. https://doi.org/10.1016/j.amjcard.2011.12.017
Bauer LK, et al. Effects of Depression and Anxiety Improvement On Adherence to Medication and Health Behaviors in Recently Hospitalized Cardiac Patients. Am J Cardiol. 2012 May 1;109(9):1266-71. PubMed PMID: 22325974.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of depression and anxiety improvement on adherence to medication and health behaviors in recently hospitalized cardiac patients. AU - Bauer,Leah K, AU - Caro,Mario A, AU - Beach,Scott R, AU - Mastromauro,Carol A, AU - Lenihan,Emma, AU - Januzzi,James L, AU - Huffman,Jeff C, Y1 - 2012/02/09/ PY - 2011/10/26/received PY - 2011/12/19/revised PY - 2011/12/19/accepted PY - 2012/2/14/entrez PY - 2012/2/14/pubmed PY - 2012/6/27/medline SP - 1266 EP - 71 JF - The American journal of cardiology JO - Am. J. Cardiol. VL - 109 IS - 9 N2 - Impaired adherence to medications and health behaviors may mediate the connection between psychiatric symptoms and mortality in cardiac patients. This study assessed the association between improvements in depression/anxiety and self-reported adherence to health behaviors in depressed cardiac patients in the 6 months after cardiac hospitalization. Data were analyzed from depressed patients on inpatient cardiac units who were hospitalized for acute coronary syndrome, heart failure, or arrhythmia and enrolled in a randomized trial of collaborative care depression management (n = 134 in primary analysis). Measurements of depression (Patient Health Questionnaire-9), anxiety (Hospital Anxiety and Depression Scale, Anxiety subscale), and adherence to secondary prevention behaviors (Medical Outcomes Study-Specific Adherence Scale items) were obtained at baseline, 6 weeks 12 weeks, and 6 months. The association between improvement in depression/anxiety and adherence was assessed by linear regression after accounting for the effects of multiple relevant covariates. At all time points improvement in the Patient Health Questionnaire-9 was significantly and independently associated with self-reported adherence to medications and secondary prevention behaviors. In contrast, improvement in the Hospital Anxiety and Depression Scale, Anxiety subscale was associated with improved adherence only at 6 weeks. In conclusion, in a cohort of depressed cardiac patients, improvement in depression was consistently and independently associated with superior self-reported adherence to medications and secondary prevention behaviors across a 6-month span, whereas improvement in anxiety was not. SN - 1879-1913 UR - https://www.unboundmedicine.com/medline/citation/22325974/Effects_of_depression_and_anxiety_improvement_on_adherence_to_medication_and_health_behaviors_in_recently_hospitalized_cardiac_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(12)00054-9 DB - PRIME DP - Unbound Medicine ER -