Tags

Type your tag names separated by a space and hit enter

Preventive effects of North American ginseng (Panax quinquefolium) on diabetic nephropathy.

Abstract

PURPOSE

Ginseng has been used as an herbal medicine and nutritional supplement in East Asia for thousands of years and gained popularity in the west because of its various pharmacological properties. Panax ginseng (Asian ginseng) and Panax quinquefolium (North American ginseng) both are reported to possess antihyperglycemic properties. The aim of the present study is to evaluate the preventive effects of North American ginseng on diabetic nephropathy (DN) and the underlying mechanisms of such effects.

METHODS

Models of both type 1 (C57BL/6 mice with STZ-induced diabetes) and type 2 diabetes (db/db mice) and age- and sex-matched controls were examined. Alcoholic ginseng root (200mg/kgbodywt, daily oral gavage) extract was administered to the diabetic mice (type 1 and type 2) for two or four months in order to evaluate its effects on DN.

RESULTS

Dysmetabolic state in the diabetic mice was significantly improved by ginseng treatment. In the kidneys of diabetic animals, ginseng significantly prevented oxidative stress and reduced the NF-κB (p65) levels. Diabetes-induced up-regulations of ECM proteins and vasoactive factors in the kidneys were significantly diminished by ginseng administration. Furthermore, albuminuria and mesangial expansion in the diabetic mice were prevented by ginseng therapy.

CONCLUSION

North American ginseng has preventive effects on DN and it works through a combination of mechanisms such as antihyperglycemic and antioxidant activities.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Pathology, University of Western Ontario, Schulich School of Medicine and Dentistry, London, Ontario, Canada.

    , , , ,

    Source

    MeSH

    Animals
    Antioxidants
    Diabetes Mellitus
    Diabetes Mellitus, Experimental
    Diabetic Nephropathies
    Drug Evaluation
    Far East
    Hypoglycemic Agents
    Mice
    Mice, Inbred C57BL
    North America
    Ontario
    Panax
    Phytotherapy
    Plant Extracts
    Plant Roots
    Plants, Medicinal

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22326549

    Citation

    Sen, Subhrojit, et al. "Preventive Effects of North American Ginseng (Panax Quinquefolium) On Diabetic Nephropathy." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 19, no. 6, 2012, pp. 494-505.
    Sen S, Chen S, Feng B, et al. Preventive effects of North American ginseng (Panax quinquefolium) on diabetic nephropathy. Phytomedicine. 2012;19(6):494-505.
    Sen, S., Chen, S., Feng, B., Wu, Y., Lui, E., & Chakrabarti, S. (2012). Preventive effects of North American ginseng (Panax quinquefolium) on diabetic nephropathy. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 19(6), pp. 494-505. doi:10.1016/j.phymed.2012.01.001.
    Sen S, et al. Preventive Effects of North American Ginseng (Panax Quinquefolium) On Diabetic Nephropathy. Phytomedicine. 2012 Apr 15;19(6):494-505. PubMed PMID: 22326549.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Preventive effects of North American ginseng (Panax quinquefolium) on diabetic nephropathy. AU - Sen,Subhrojit, AU - Chen,Shali, AU - Feng,Biao, AU - Wu,Yuexiu, AU - Lui,Edmund, AU - Chakrabarti,Subrata, Y1 - 2012/02/10/ PY - 2012/2/14/entrez PY - 2012/2/14/pubmed PY - 2012/7/31/medline SP - 494 EP - 505 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 19 IS - 6 N2 - PURPOSE: Ginseng has been used as an herbal medicine and nutritional supplement in East Asia for thousands of years and gained popularity in the west because of its various pharmacological properties. Panax ginseng (Asian ginseng) and Panax quinquefolium (North American ginseng) both are reported to possess antihyperglycemic properties. The aim of the present study is to evaluate the preventive effects of North American ginseng on diabetic nephropathy (DN) and the underlying mechanisms of such effects. METHODS: Models of both type 1 (C57BL/6 mice with STZ-induced diabetes) and type 2 diabetes (db/db mice) and age- and sex-matched controls were examined. Alcoholic ginseng root (200mg/kgbodywt, daily oral gavage) extract was administered to the diabetic mice (type 1 and type 2) for two or four months in order to evaluate its effects on DN. RESULTS: Dysmetabolic state in the diabetic mice was significantly improved by ginseng treatment. In the kidneys of diabetic animals, ginseng significantly prevented oxidative stress and reduced the NF-κB (p65) levels. Diabetes-induced up-regulations of ECM proteins and vasoactive factors in the kidneys were significantly diminished by ginseng administration. Furthermore, albuminuria and mesangial expansion in the diabetic mice were prevented by ginseng therapy. CONCLUSION: North American ginseng has preventive effects on DN and it works through a combination of mechanisms such as antihyperglycemic and antioxidant activities. SN - 1618-095X UR - https://www.unboundmedicine.com/medline/citation/22326549/Preventive_effects_of_North_American_ginseng__Panax_quinquefolium__on_diabetic_nephropathy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(12)00008-6 DB - PRIME DP - Unbound Medicine ER -