Tags

Type your tag names separated by a space and hit enter

Apolipoprotein E gene associations in age-related macular degeneration: the Melbourne Collaborative Cohort Study.
Am J Epidemiol. 2012 Mar 15; 175(6):511-8.AJ

Abstract

The apolipoprotein E gene (APOE) has been found to be associated with age-related macular degeneration (AMD). Reported associations have been questioned, as they are opposite those for Alzheimer's disease and cardiovascular disease. The authors examined associations between APOE genotype and AMD using a case-control study (2,287 cases and 2,287 controls individually matched on age, sex, and country of origin) nested within Melbourne Collaborative Cohort Study participants aged 48-86 years at AMD detection. The odds ratio for early AMD among participants with ε2-containing genotypes (ε2ε2/ε2ε3/ε2ε4) was 1.32 (95% confidence interval (CI): 1.11, 1.58; P = 0.002) versus persons with genotype ε3ε3. Associations with early AMD varied by smoking status; ε2-containing genotypes were positively associated with early AMD for never and previous smokers (never smokers: odds ratio (OR) = 1.40, 95% CI: 1.12, 1.76 (P = 0.003); previous smokers: OR = 1.39, 95% CI: 1.00, 1.93 (P = 0.05)) but not for current smokers (OR = 0.66, 95% CI: 0.34, 1.30 (P = 0.2; interaction P = 0.05). The ε4-containing genotype group (ε3ε4/ε4ε4) had an inverse association with early AMD among current smokers only (OR = 0.41, 95% CI: 0.22, 0.77 (P = 0.005)). These results highlight the importance of stratifying by smoking status in elderly populations. Smokers who survive to old age may be more likely to possess unknown genotypes which modify exposure-disease associations.

Authors+Show Affiliations

Center for Eye Research Australia, University of Melbourne/Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia. madam@student.unimelb.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22328704

Citation

Adams, Madeleine K M., et al. "Apolipoprotein E Gene Associations in Age-related Macular Degeneration: the Melbourne Collaborative Cohort Study." American Journal of Epidemiology, vol. 175, no. 6, 2012, pp. 511-8.
Adams MK, Simpson JA, Richardson AJ, et al. Apolipoprotein E gene associations in age-related macular degeneration: the Melbourne Collaborative Cohort Study. Am J Epidemiol. 2012;175(6):511-8.
Adams, M. K., Simpson, J. A., Richardson, A. J., English, D. R., Aung, K. Z., Makeyeva, G. A., Guymer, R. H., Giles, G. G., Hopper, J., Robman, L. D., & Baird, P. N. (2012). Apolipoprotein E gene associations in age-related macular degeneration: the Melbourne Collaborative Cohort Study. American Journal of Epidemiology, 175(6), 511-8. https://doi.org/10.1093/aje/kwr329
Adams MK, et al. Apolipoprotein E Gene Associations in Age-related Macular Degeneration: the Melbourne Collaborative Cohort Study. Am J Epidemiol. 2012 Mar 15;175(6):511-8. PubMed PMID: 22328704.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E gene associations in age-related macular degeneration: the Melbourne Collaborative Cohort Study. AU - Adams,Madeleine K M, AU - Simpson,Julie A, AU - Richardson,Andrea J, AU - English,Dallas R, AU - Aung,Khin Zaw, AU - Makeyeva,Galina A, AU - Guymer,Robyn H, AU - Giles,Graham G, AU - Hopper,John, AU - Robman,Liubov D, AU - Baird,Paul N, Y1 - 2012/02/10/ PY - 2012/2/14/entrez PY - 2012/2/14/pubmed PY - 2012/5/1/medline SP - 511 EP - 8 JF - American journal of epidemiology JO - Am J Epidemiol VL - 175 IS - 6 N2 - The apolipoprotein E gene (APOE) has been found to be associated with age-related macular degeneration (AMD). Reported associations have been questioned, as they are opposite those for Alzheimer's disease and cardiovascular disease. The authors examined associations between APOE genotype and AMD using a case-control study (2,287 cases and 2,287 controls individually matched on age, sex, and country of origin) nested within Melbourne Collaborative Cohort Study participants aged 48-86 years at AMD detection. The odds ratio for early AMD among participants with ε2-containing genotypes (ε2ε2/ε2ε3/ε2ε4) was 1.32 (95% confidence interval (CI): 1.11, 1.58; P = 0.002) versus persons with genotype ε3ε3. Associations with early AMD varied by smoking status; ε2-containing genotypes were positively associated with early AMD for never and previous smokers (never smokers: odds ratio (OR) = 1.40, 95% CI: 1.12, 1.76 (P = 0.003); previous smokers: OR = 1.39, 95% CI: 1.00, 1.93 (P = 0.05)) but not for current smokers (OR = 0.66, 95% CI: 0.34, 1.30 (P = 0.2; interaction P = 0.05). The ε4-containing genotype group (ε3ε4/ε4ε4) had an inverse association with early AMD among current smokers only (OR = 0.41, 95% CI: 0.22, 0.77 (P = 0.005)). These results highlight the importance of stratifying by smoking status in elderly populations. Smokers who survive to old age may be more likely to possess unknown genotypes which modify exposure-disease associations. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/22328704/Apolipoprotein_E_gene_associations_in_age_related_macular_degeneration:_the_Melbourne_Collaborative_Cohort_Study_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwr329 DB - PRIME DP - Unbound Medicine ER -