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Role and function of macrophages in the metabolic syndrome.
Biochem J. 2012 Mar 01; 442(2):253-62.BJ

Abstract

Macrophages are key innate immune effector cells best known for their role as professional phagocytes, which also include neutrophils and dendritic cells. Recent evidence indicates that macrophages are also key players in metabolic homoeostasis. Macrophages can be found in many tissues, where they respond to metabolic cues and produce pro- and/or anti-inflammatory mediators to modulate metabolite programmes. Certain metabolites, such as fatty acids, ceramides and cholesterol crystals, elicit inflammatory responses through pathogen-sensing signalling pathways, implicating a maladaptation of macrophages and the innate immune system to elevated metabolic stress associated with overnutrition in modern societies. The outcome of this maladaptation is a feedforward inflammatory response leading to a state of unresolved inflammation and a collection of metabolic pathologies, including insulin resistance, fatty liver, atherosclerosis and dyslipidaemia. The present review summarizes what is known about the contributions of macrophages to metabolic diseases and the signalling pathways that are involved in metabolic stress-induced macrophage activation. Understanding the role of macrophages in these processes will help us to develop therapies against detrimental effects of the metabolic syndrome.

Authors+Show Affiliations

Department of Genetics and Complex Diseases, Department of Nutrition, Division of Biological Sciences, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, U.S.A.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

22329799

Citation

Bhargava, Prerna, and Chih-Hao Lee. "Role and Function of Macrophages in the Metabolic Syndrome." The Biochemical Journal, vol. 442, no. 2, 2012, pp. 253-62.
Bhargava P, Lee CH. Role and function of macrophages in the metabolic syndrome. Biochem J. 2012;442(2):253-62.
Bhargava, P., & Lee, C. H. (2012). Role and function of macrophages in the metabolic syndrome. The Biochemical Journal, 442(2), 253-62. https://doi.org/10.1042/BJ20111708
Bhargava P, Lee CH. Role and Function of Macrophages in the Metabolic Syndrome. Biochem J. 2012 Mar 1;442(2):253-62. PubMed PMID: 22329799.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role and function of macrophages in the metabolic syndrome. AU - Bhargava,Prerna, AU - Lee,Chih-Hao, PY - 2012/2/15/entrez PY - 2012/2/15/pubmed PY - 2012/4/10/medline SP - 253 EP - 62 JF - The Biochemical journal JO - Biochem J VL - 442 IS - 2 N2 - Macrophages are key innate immune effector cells best known for their role as professional phagocytes, which also include neutrophils and dendritic cells. Recent evidence indicates that macrophages are also key players in metabolic homoeostasis. Macrophages can be found in many tissues, where they respond to metabolic cues and produce pro- and/or anti-inflammatory mediators to modulate metabolite programmes. Certain metabolites, such as fatty acids, ceramides and cholesterol crystals, elicit inflammatory responses through pathogen-sensing signalling pathways, implicating a maladaptation of macrophages and the innate immune system to elevated metabolic stress associated with overnutrition in modern societies. The outcome of this maladaptation is a feedforward inflammatory response leading to a state of unresolved inflammation and a collection of metabolic pathologies, including insulin resistance, fatty liver, atherosclerosis and dyslipidaemia. The present review summarizes what is known about the contributions of macrophages to metabolic diseases and the signalling pathways that are involved in metabolic stress-induced macrophage activation. Understanding the role of macrophages in these processes will help us to develop therapies against detrimental effects of the metabolic syndrome. SN - 1470-8728 UR - https://www.unboundmedicine.com/medline/citation/22329799/Role_and_function_of_macrophages_in_the_metabolic_syndrome_ L2 - https://portlandpress.com/biochemj/article-lookup/doi/10.1042/BJ20111708 DB - PRIME DP - Unbound Medicine ER -