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Enhanced antimicrobial activity of nisin-loaded liposomal nanoparticles against foodborne pathogens.
J Food Sci. 2012 Mar; 77(3):M165-70.JF

Abstract

This study was designed to evaluate the prolonged antimicrobial stability of nisin-loaded liposome (LipoN) nanoparticles against Listeria monocytogenes and Staphylococcus aureus. The sizes of bare liposomes and LipoN were uniformly distributed between 114 and 125 nm. The nanoparticles were homogeneously dispersed in water with less than 0.2 of polydispersity index. The zeta potential value of LipoN was +17.1 mV due to the positive charged nisin, attaining 70% of loading efficiency. The minimum inhibitory concentration of LipoN against L. monocytogenes and S. aureus was 320 international unit/mL. The LipoN significantly enhanced the antimicrobial stability in brain heart infusion agar compared to free nisin. The numbers of L. monocytogenes and S. aureus exposed to LipoN were effectively reduced by more than 6 log colony-forming unit/mL after 48 and 72 h of incubation, respectively. These results provide useful information for the development of antimicrobial delivery system to improve food safety.

Authors+Show Affiliations

Div. of Biomaterials Engineering, Kangwon Natl. Univ., Chuncheon, Gangwon 200-701, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22329855

Citation

Zou, Yunyun, et al. "Enhanced Antimicrobial Activity of Nisin-loaded Liposomal Nanoparticles Against Foodborne Pathogens." Journal of Food Science, vol. 77, no. 3, 2012, pp. M165-70.
Zou Y, Lee HY, Seo YC, et al. Enhanced antimicrobial activity of nisin-loaded liposomal nanoparticles against foodborne pathogens. J Food Sci. 2012;77(3):M165-70.
Zou, Y., Lee, H. Y., Seo, Y. C., & Ahn, J. (2012). Enhanced antimicrobial activity of nisin-loaded liposomal nanoparticles against foodborne pathogens. Journal of Food Science, 77(3), M165-70. https://doi.org/10.1111/j.1750-3841.2011.02580.x
Zou Y, et al. Enhanced Antimicrobial Activity of Nisin-loaded Liposomal Nanoparticles Against Foodborne Pathogens. J Food Sci. 2012;77(3):M165-70. PubMed PMID: 22329855.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enhanced antimicrobial activity of nisin-loaded liposomal nanoparticles against foodborne pathogens. AU - Zou,Yunyun, AU - Lee,Hyeon-Yong, AU - Seo,Yong-Chang, AU - Ahn,Juhee, Y1 - 2012/02/13/ PY - 2012/2/15/entrez PY - 2012/2/15/pubmed PY - 2012/7/6/medline SP - M165 EP - 70 JF - Journal of food science JO - J. Food Sci. VL - 77 IS - 3 N2 - This study was designed to evaluate the prolonged antimicrobial stability of nisin-loaded liposome (LipoN) nanoparticles against Listeria monocytogenes and Staphylococcus aureus. The sizes of bare liposomes and LipoN were uniformly distributed between 114 and 125 nm. The nanoparticles were homogeneously dispersed in water with less than 0.2 of polydispersity index. The zeta potential value of LipoN was +17.1 mV due to the positive charged nisin, attaining 70% of loading efficiency. The minimum inhibitory concentration of LipoN against L. monocytogenes and S. aureus was 320 international unit/mL. The LipoN significantly enhanced the antimicrobial stability in brain heart infusion agar compared to free nisin. The numbers of L. monocytogenes and S. aureus exposed to LipoN were effectively reduced by more than 6 log colony-forming unit/mL after 48 and 72 h of incubation, respectively. These results provide useful information for the development of antimicrobial delivery system to improve food safety. SN - 1750-3841 UR - https://www.unboundmedicine.com/medline/citation/22329855/Enhanced_antimicrobial_activity_of_nisin_loaded_liposomal_nanoparticles_against_foodborne_pathogens_ L2 - https://doi.org/10.1111/j.1750-3841.2011.02580.x DB - PRIME DP - Unbound Medicine ER -