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Highly efficient asymmetric aldol reaction in brine using a fluorous sulfonamide organocatalyst.
Org Biomol Chem. 2012 Mar 21; 10(11):2209-13.OB

Abstract

A fluorous organocatalyst promotes direct asymmetric aldol reactions of aromatic aldehydes with ketones in brine to afford the corresponding anti-aldol products in high yield with up to 96% ee. Fluorous organocatalyst can be readily recovered by solid phase extraction using fluorous silica gel and reused without purification.

Authors+Show Affiliations

Gifu Pharmaceutical University 1-25-4, Daigaku-nishi, Gifu 501-1196, Japan. miura@gifu-pu.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22331195

Citation

Miura, Tsuyoshi, et al. "Highly Efficient Asymmetric Aldol Reaction in Brine Using a Fluorous Sulfonamide Organocatalyst." Organic & Biomolecular Chemistry, vol. 10, no. 11, 2012, pp. 2209-13.
Miura T, Kasuga H, Imai K, et al. Highly efficient asymmetric aldol reaction in brine using a fluorous sulfonamide organocatalyst. Org Biomol Chem. 2012;10(11):2209-13.
Miura, T., Kasuga, H., Imai, K., Ina, M., Tada, N., Imai, N., & Itoh, A. (2012). Highly efficient asymmetric aldol reaction in brine using a fluorous sulfonamide organocatalyst. Organic & Biomolecular Chemistry, 10(11), 2209-13. https://doi.org/10.1039/c2ob06955e
Miura T, et al. Highly Efficient Asymmetric Aldol Reaction in Brine Using a Fluorous Sulfonamide Organocatalyst. Org Biomol Chem. 2012 Mar 21;10(11):2209-13. PubMed PMID: 22331195.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Highly efficient asymmetric aldol reaction in brine using a fluorous sulfonamide organocatalyst. AU - Miura,Tsuyoshi, AU - Kasuga,Hikaru, AU - Imai,Kie, AU - Ina,Mariko, AU - Tada,Norihiro, AU - Imai,Nobuyuki, AU - Itoh,Akichika, Y1 - 2012/02/14/ PY - 2012/2/15/entrez PY - 2012/2/15/pubmed PY - 2012/6/6/medline SP - 2209 EP - 13 JF - Organic & biomolecular chemistry JO - Org Biomol Chem VL - 10 IS - 11 N2 - A fluorous organocatalyst promotes direct asymmetric aldol reactions of aromatic aldehydes with ketones in brine to afford the corresponding anti-aldol products in high yield with up to 96% ee. Fluorous organocatalyst can be readily recovered by solid phase extraction using fluorous silica gel and reused without purification. SN - 1477-0539 UR - https://www.unboundmedicine.com/medline/citation/22331195/Highly_efficient_asymmetric_aldol_reaction_in_brine_using_a_fluorous_sulfonamide_organocatalyst_ L2 - https://doi.org/10.1039/c2ob06955e DB - PRIME DP - Unbound Medicine ER -