Tags

Type your tag names separated by a space and hit enter

Highly efficient asymmetric aldol reaction in brine using a fluorous sulfonamide organocatalyst.
Org Biomol Chem. 2012 Mar 21; 10(11):2209-13.OB

Abstract

A fluorous organocatalyst promotes direct asymmetric aldol reactions of aromatic aldehydes with ketones in brine to afford the corresponding anti-aldol products in high yield with up to 96% ee. Fluorous organocatalyst can be readily recovered by solid phase extraction using fluorous silica gel and reused without purification.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Miura T
Gifu Pharmaceutical University 1-25-4, Daigaku-nishi, Gifu 501-1196, Japan. miura@gifu-pu.ac.jp
Kasuga H
No affiliation info available
Imai K
No affiliation info available
Ina M
No affiliation info available
Tada N
No affiliation info available
Imai N
No affiliation info available
Itoh A
No affiliation info available

MeSH

AldehydesCatalysisFluorine CompoundsMolecular StructureSaltsStereoisomerismSulfonamides

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22331195

Citation

Miura, Tsuyoshi, et al. "Highly Efficient Asymmetric Aldol Reaction in Brine Using a Fluorous Sulfonamide Organocatalyst." Organic & Biomolecular Chemistry, vol. 10, no. 11, 2012, pp. 2209-13.
Miura T, Kasuga H, Imai K, et al. Highly efficient asymmetric aldol reaction in brine using a fluorous sulfonamide organocatalyst. Org Biomol Chem. 2012;10(11):2209-13.
Miura, T., Kasuga, H., Imai, K., Ina, M., Tada, N., Imai, N., & Itoh, A. (2012). Highly efficient asymmetric aldol reaction in brine using a fluorous sulfonamide organocatalyst. Organic & Biomolecular Chemistry, 10(11), 2209-13. https://doi.org/10.1039/c2ob06955e
Miura T, et al. Highly Efficient Asymmetric Aldol Reaction in Brine Using a Fluorous Sulfonamide Organocatalyst. Org Biomol Chem. 2012 Mar 21;10(11):2209-13. PubMed PMID: 22331195.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Highly efficient asymmetric aldol reaction in brine using a fluorous sulfonamide organocatalyst. AU - Miura,Tsuyoshi, AU - Kasuga,Hikaru, AU - Imai,Kie, AU - Ina,Mariko, AU - Tada,Norihiro, AU - Imai,Nobuyuki, AU - Itoh,Akichika, Y1 - 2012/02/14/ PY - 2012/2/15/entrez PY - 2012/2/15/pubmed PY - 2012/6/6/medline SP - 2209 EP - 13 JF - Organic & biomolecular chemistry JO - Org Biomol Chem VL - 10 IS - 11 N2 - A fluorous organocatalyst promotes direct asymmetric aldol reactions of aromatic aldehydes with ketones in brine to afford the corresponding anti-aldol products in high yield with up to 96% ee. Fluorous organocatalyst can be readily recovered by solid phase extraction using fluorous silica gel and reused without purification. SN - 1477-0539 UR - https://www.unboundmedicine.com/medline/citation/22331195/Highly_efficient_asymmetric_aldol_reaction_in_brine_using_a_fluorous_sulfonamide_organocatalyst_ L2 - https://doi.org/10.1039/c2ob06955e DB - PRIME DP - Unbound Medicine ER -