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The chain length of dietary saturated fatty acids affects human postprandial lipemia.
J Am Coll Nutr 2011; 30(6):511-21JA

Abstract

OBJECTIVE

Saturated fats increase total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C) and are linked to coronary artery disease risk. The effect of variance in chain length of saturated fatty acids (SFA) on coronary artery disease in human postprandial lipemia is not well elucidated.

METHODS

A total of 20 healthy volunteers were challenged with 3 test meals, similar in fat content (~31% en) but varying in saturated SFA content and polyunsaturated/saturated fatty acid ratios (P/S). The 3 meals were lauric + myristic acid-rich (LM), P/S 0.19; palmitic acid-rich (POL), P/S 0.31; and stearic acid-rich (STE), P/S 0.22. Blood was sampled at fasted baseline and 2, 4, 5, 6, and 8 hours. Plasma lipids (triacylglycerol [TAG]) and lipoproteins (TC, LDL-C, high density lipoprotein-cholesterol [HDL-C]) were evaluated.

RESULTS

Varying SFA in the test meal significantly impacted postprandial TAG response (p < 0.05). Plasma TAG peaked at 5 hours for STE, 4 hours for POL, and 2 hours for LM test meals. Area-under-the-curve (AUC) for plasma TAG was increased significantly after STE treatment (STE > LM by 32.2%, p = 0.003; STE > POL by 27.9%, p = 0.023) but was not significantly different between POL and LM (POL > LM by 6.0%, p > 0.05). At 2 hours, plasma HDL-C increased significantly after the LM and POL test meals compared with STE (p < 0.05). In comparison to the STE test meal, HDL-C AUC was elevated 14.0% (p = 0.005) and 7.6% (p = 0.023) by the LM and POL test meals, respectively. The TC response was also increased significantly by LM compared with both POL and STE test meals (p < 0.05).

CONCLUSIONS

Chain length of saturates clearly mediated postmeal plasma TAG and HDL-C changes.

Authors+Show Affiliations

Malaysian Palm Oil Council, Kelana Jaya, Selangor, Malaysia.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22331686

Citation

Karupaiah, Tilakavati, et al. "The Chain Length of Dietary Saturated Fatty Acids Affects Human Postprandial Lipemia." Journal of the American College of Nutrition, vol. 30, no. 6, 2011, pp. 511-21.
Karupaiah T, Tan CH, Chinna K, et al. The chain length of dietary saturated fatty acids affects human postprandial lipemia. J Am Coll Nutr. 2011;30(6):511-21.
Karupaiah, T., Tan, C. H., Chinna, K., & Sundram, K. (2011). The chain length of dietary saturated fatty acids affects human postprandial lipemia. Journal of the American College of Nutrition, 30(6), pp. 511-21.
Karupaiah T, et al. The Chain Length of Dietary Saturated Fatty Acids Affects Human Postprandial Lipemia. J Am Coll Nutr. 2011;30(6):511-21. PubMed PMID: 22331686.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The chain length of dietary saturated fatty acids affects human postprandial lipemia. AU - Karupaiah,Tilakavati, AU - Tan,Choon H, AU - Chinna,Karuthan, AU - Sundram,Kalyana, PY - 2012/2/15/entrez PY - 2012/2/15/pubmed PY - 2012/6/8/medline SP - 511 EP - 21 JF - Journal of the American College of Nutrition JO - J Am Coll Nutr VL - 30 IS - 6 N2 - OBJECTIVE: Saturated fats increase total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C) and are linked to coronary artery disease risk. The effect of variance in chain length of saturated fatty acids (SFA) on coronary artery disease in human postprandial lipemia is not well elucidated. METHODS: A total of 20 healthy volunteers were challenged with 3 test meals, similar in fat content (~31% en) but varying in saturated SFA content and polyunsaturated/saturated fatty acid ratios (P/S). The 3 meals were lauric + myristic acid-rich (LM), P/S 0.19; palmitic acid-rich (POL), P/S 0.31; and stearic acid-rich (STE), P/S 0.22. Blood was sampled at fasted baseline and 2, 4, 5, 6, and 8 hours. Plasma lipids (triacylglycerol [TAG]) and lipoproteins (TC, LDL-C, high density lipoprotein-cholesterol [HDL-C]) were evaluated. RESULTS: Varying SFA in the test meal significantly impacted postprandial TAG response (p < 0.05). Plasma TAG peaked at 5 hours for STE, 4 hours for POL, and 2 hours for LM test meals. Area-under-the-curve (AUC) for plasma TAG was increased significantly after STE treatment (STE > LM by 32.2%, p = 0.003; STE > POL by 27.9%, p = 0.023) but was not significantly different between POL and LM (POL > LM by 6.0%, p > 0.05). At 2 hours, plasma HDL-C increased significantly after the LM and POL test meals compared with STE (p < 0.05). In comparison to the STE test meal, HDL-C AUC was elevated 14.0% (p = 0.005) and 7.6% (p = 0.023) by the LM and POL test meals, respectively. The TC response was also increased significantly by LM compared with both POL and STE test meals (p < 0.05). CONCLUSIONS: Chain length of saturates clearly mediated postmeal plasma TAG and HDL-C changes. SN - 1541-1087 UR - https://www.unboundmedicine.com/medline/citation/22331686/The_chain_length_of_dietary_saturated_fatty_acids_affects_human_postprandial_lipemia_ L2 - http://www.tandfonline.com/doi/full/10.1080/07315724.2011.10719997 DB - PRIME DP - Unbound Medicine ER -