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Advances in the understanding of mammalian copper transporters.
Adv Nutr. 2011 Mar; 2(2):129-37.AN

Abstract

Copper (Cu) is an essential micronutrient. Its ability to exist in 2 oxidation states (Cu(1+) and Cu(2+)) allows it to function as an enzymatic cofactor in hydrolytic, electron transfer, and oxygen utilization reactions. Cu transporters CTR1, ATP7A, and ATP7B play key roles in ensuring that adequate Cu is available for Cu-requiring processes and the prevention of excess Cu accumulation within cells. Two diseases of Cu metabolism, Menkes disease and Wilson disease, which are caused by mutations in ATP7A and ATP7B, respectively, exemplify the critical importance of regulating Cu balance in humans. Herein, we review recent studies of the biochemical and cell biological characteristics of CTR1, ATP7A, and ATP7B, as well as emerging roles for Cu in new areas of physiology.

Authors+Show Affiliations

Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

22332042

Citation

Wang, Yanfang, et al. "Advances in the Understanding of Mammalian Copper Transporters." Advances in Nutrition (Bethesda, Md.), vol. 2, no. 2, 2011, pp. 129-37.
Wang Y, Hodgkinson V, Zhu S, et al. Advances in the understanding of mammalian copper transporters. Adv Nutr. 2011;2(2):129-37.
Wang, Y., Hodgkinson, V., Zhu, S., Weisman, G. A., & Petris, M. J. (2011). Advances in the understanding of mammalian copper transporters. Advances in Nutrition (Bethesda, Md.), 2(2), 129-37. https://doi.org/10.3945/an.110.000273
Wang Y, et al. Advances in the Understanding of Mammalian Copper Transporters. Adv Nutr. 2011;2(2):129-37. PubMed PMID: 22332042.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Advances in the understanding of mammalian copper transporters. AU - Wang,Yanfang, AU - Hodgkinson,Victoria, AU - Zhu,Sha, AU - Weisman,Gary A, AU - Petris,Michael J, Y1 - 2011/03/10/ PY - 2012/2/15/entrez PY - 2012/2/15/pubmed PY - 2012/6/20/medline SP - 129 EP - 37 JF - Advances in nutrition (Bethesda, Md.) JO - Adv Nutr VL - 2 IS - 2 N2 - Copper (Cu) is an essential micronutrient. Its ability to exist in 2 oxidation states (Cu(1+) and Cu(2+)) allows it to function as an enzymatic cofactor in hydrolytic, electron transfer, and oxygen utilization reactions. Cu transporters CTR1, ATP7A, and ATP7B play key roles in ensuring that adequate Cu is available for Cu-requiring processes and the prevention of excess Cu accumulation within cells. Two diseases of Cu metabolism, Menkes disease and Wilson disease, which are caused by mutations in ATP7A and ATP7B, respectively, exemplify the critical importance of regulating Cu balance in humans. Herein, we review recent studies of the biochemical and cell biological characteristics of CTR1, ATP7A, and ATP7B, as well as emerging roles for Cu in new areas of physiology. SN - 2156-5376 UR - https://www.unboundmedicine.com/medline/citation/22332042/Advances_in_the_understanding_of_mammalian_copper_transporters_ L2 - https://academic.oup.com/advances/article-lookup/doi/10.3945/an.110.000273 DB - PRIME DP - Unbound Medicine ER -