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[Small fibre neuropathy: knowledge is power].
Ned Tijdschr Geneeskd. 2012; 156(7):A4224.NT

Abstract

Small fibre neuropathy is a neuropathy of the small non-myelinated C-fibres and myelinated Aδ-fibres. Clinically, an isolated small fibre neuropathy is distinguished by sensory and autonomic symptoms, with practically no abnormalities on neurological examination other than possible distorted pain and temperature sensation. Specific diagnostic tests for small fibre neuropathy are skin biopsy, including a count of the intra-epidermal small nerve fibres that cross the basal membrane, and quantitative sensory and autonomic testing. Diabetes mellitus is the most frequent underlying cause of small fibre neuropathy. Other causes can be classified into the following categories: toxic (e.g. alcohol), metabolic, immune-mediated, infectious and hereditary. Recently, in a substantial proportion (29%) of a group of patients with idiopathic small fibre neuropathy, a SCN9A gene mutation was demonstrated, which leads to hyperexcitability of the dorsal root ganglion neurons. Treatment of small fibre neuropathy consists of symptomatic pain relief and, if possible, treatment of the underlying cause of the condition.

Authors+Show Affiliations

Maastricht Universitair Medisch Centrum, Maastricht, the Netherlands. j.hoeijmakers@mumc.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

dut

PubMed ID

22333400

Citation

Hoeijmakers, Jannkek G J., et al. "[Small Fibre Neuropathy: Knowledge Is Power]." Nederlands Tijdschrift Voor Geneeskunde, vol. 156, no. 7, 2012, pp. A4224.
Hoeijmakers JG, Bakkers M, Blom EW, et al. [Small fibre neuropathy: knowledge is power]. Ned Tijdschr Geneeskd. 2012;156(7):A4224.
Hoeijmakers, J. G., Bakkers, M., Blom, E. W., Drenth, J. P., Merkies, I. S., & Faber, C. G. (2012). [Small fibre neuropathy: knowledge is power]. Nederlands Tijdschrift Voor Geneeskunde, 156(7), A4224.
Hoeijmakers JG, et al. [Small Fibre Neuropathy: Knowledge Is Power]. Ned Tijdschr Geneeskd. 2012;156(7):A4224. PubMed PMID: 22333400.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Small fibre neuropathy: knowledge is power]. AU - Hoeijmakers,Jannkek G J, AU - Bakkers,Mayienne, AU - Blom,Eveline W, AU - Drenth,Joost P H, AU - Merkies,Ingemar S J, AU - Faber,Catharina G, PY - 2012/2/16/entrez PY - 2012/2/16/pubmed PY - 2012/3/28/medline SP - A4224 EP - A4224 JF - Nederlands tijdschrift voor geneeskunde JO - Ned Tijdschr Geneeskd VL - 156 IS - 7 N2 - Small fibre neuropathy is a neuropathy of the small non-myelinated C-fibres and myelinated Aδ-fibres. Clinically, an isolated small fibre neuropathy is distinguished by sensory and autonomic symptoms, with practically no abnormalities on neurological examination other than possible distorted pain and temperature sensation. Specific diagnostic tests for small fibre neuropathy are skin biopsy, including a count of the intra-epidermal small nerve fibres that cross the basal membrane, and quantitative sensory and autonomic testing. Diabetes mellitus is the most frequent underlying cause of small fibre neuropathy. Other causes can be classified into the following categories: toxic (e.g. alcohol), metabolic, immune-mediated, infectious and hereditary. Recently, in a substantial proportion (29%) of a group of patients with idiopathic small fibre neuropathy, a SCN9A gene mutation was demonstrated, which leads to hyperexcitability of the dorsal root ganglion neurons. Treatment of small fibre neuropathy consists of symptomatic pain relief and, if possible, treatment of the underlying cause of the condition. SN - 1876-8784 UR - https://www.unboundmedicine.com/medline/citation/22333400/[Small_fibre_neuropathy:_knowledge_is_power]_ L2 - https://www.ntvg.nl/A4224 DB - PRIME DP - Unbound Medicine ER -