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Attention-deficit hyperactivity disorder symptoms in children and adolescents with sex chromosome aneuploidy: XXY, XXX, XYY, and XXYY.
J Dev Behav Pediatr. 2012 May; 33(4):309-18.JD

Abstract

OBJECTIVE

Attentional problems, hyperactivity, and impulsivity have been described as behavioral features associated with sex chromosome aneuploidy (SCA). In this study, the authors compare attention-deficit hyperactivity disorder (ADHD) symptoms in 167 participants aged 6 to 20 years with 4 types of SCA (XXY n = 56, XYY n = 33, XXX n = 25, and XXYY n = 53). They also evaluate factors associated with ADHD symptomatology (cognitive and adaptive scores, prenatal vs postnatal ascertainment) and describe the clinical response to psychopharmacologic medications in a subset of patients treated for ADHD.

METHODS

Evaluation included medical and developmental history, cognitive and adaptive functioning assessment, and parent and teacher ADHD questionnaires containing DSM-IV criteria.

RESULTS

In the total study group, 58% (96/167) met DSM-IV criteria for ADHD on parent-report questionnaires (36% in XXY, 52% in XXX, 76% in XYY, and 72% in XXYY). The Inattentive subtype was most common in XXY and XXX, whereas the XYY and XXYY groups were more likely to also have hyperactive/impulsive symptoms. There were no significant differences in Verbal, Performance, or Full Scale IQ between children with symptom scores in the ADHD range compared with those below the ADHD range. However, adaptive functioning scores were significantly lower in the group whose scores in the ADHD range were compared with those of the group who did not meet ADHD DSM-IV criteria. Those with a prenatal diagnosis of XXY were less likely to meet criteria for ADHD compared with the postnatally diagnosed group. Psychopharmacologic treatment with stimulants was effective in 78.6% (66/84).

CONCLUSIONS

Children and adolescents with SCA are at increased risk for ADHD symptoms. Recommendations for ADHD evaluation and treatment in consideration of other aspects of the SCA medical and behavioral phenotype are provided.

Authors+Show Affiliations

Neurodevelopmental and Behavioral Pediatrics, Department of Pediatrics, University of Colorado School of Medicine, Children's Hospital Colorado, 13123 East 16th Avenue, Aurora, CO, USA. Nicole.tartaglia@childrenscolorado.orgNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22333574

Citation

Tartaglia, Nicole R., et al. "Attention-deficit Hyperactivity Disorder Symptoms in Children and Adolescents With Sex Chromosome Aneuploidy: XXY, XXX, XYY, and XXYY." Journal of Developmental and Behavioral Pediatrics : JDBP, vol. 33, no. 4, 2012, pp. 309-18.
Tartaglia NR, Ayari N, Hutaff-Lee C, et al. Attention-deficit hyperactivity disorder symptoms in children and adolescents with sex chromosome aneuploidy: XXY, XXX, XYY, and XXYY. J Dev Behav Pediatr. 2012;33(4):309-18.
Tartaglia, N. R., Ayari, N., Hutaff-Lee, C., & Boada, R. (2012). Attention-deficit hyperactivity disorder symptoms in children and adolescents with sex chromosome aneuploidy: XXY, XXX, XYY, and XXYY. Journal of Developmental and Behavioral Pediatrics : JDBP, 33(4), 309-18. https://doi.org/10.1097/DBP.0b013e31824501c8
Tartaglia NR, et al. Attention-deficit Hyperactivity Disorder Symptoms in Children and Adolescents With Sex Chromosome Aneuploidy: XXY, XXX, XYY, and XXYY. J Dev Behav Pediatr. 2012;33(4):309-18. PubMed PMID: 22333574.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Attention-deficit hyperactivity disorder symptoms in children and adolescents with sex chromosome aneuploidy: XXY, XXX, XYY, and XXYY. AU - Tartaglia,Nicole R, AU - Ayari,Natalie, AU - Hutaff-Lee,Christa, AU - Boada,Richard, PY - 2012/2/16/entrez PY - 2012/2/16/pubmed PY - 2012/9/19/medline SP - 309 EP - 18 JF - Journal of developmental and behavioral pediatrics : JDBP JO - J Dev Behav Pediatr VL - 33 IS - 4 N2 - OBJECTIVE: Attentional problems, hyperactivity, and impulsivity have been described as behavioral features associated with sex chromosome aneuploidy (SCA). In this study, the authors compare attention-deficit hyperactivity disorder (ADHD) symptoms in 167 participants aged 6 to 20 years with 4 types of SCA (XXY n = 56, XYY n = 33, XXX n = 25, and XXYY n = 53). They also evaluate factors associated with ADHD symptomatology (cognitive and adaptive scores, prenatal vs postnatal ascertainment) and describe the clinical response to psychopharmacologic medications in a subset of patients treated for ADHD. METHODS: Evaluation included medical and developmental history, cognitive and adaptive functioning assessment, and parent and teacher ADHD questionnaires containing DSM-IV criteria. RESULTS: In the total study group, 58% (96/167) met DSM-IV criteria for ADHD on parent-report questionnaires (36% in XXY, 52% in XXX, 76% in XYY, and 72% in XXYY). The Inattentive subtype was most common in XXY and XXX, whereas the XYY and XXYY groups were more likely to also have hyperactive/impulsive symptoms. There were no significant differences in Verbal, Performance, or Full Scale IQ between children with symptom scores in the ADHD range compared with those below the ADHD range. However, adaptive functioning scores were significantly lower in the group whose scores in the ADHD range were compared with those of the group who did not meet ADHD DSM-IV criteria. Those with a prenatal diagnosis of XXY were less likely to meet criteria for ADHD compared with the postnatally diagnosed group. Psychopharmacologic treatment with stimulants was effective in 78.6% (66/84). CONCLUSIONS: Children and adolescents with SCA are at increased risk for ADHD symptoms. Recommendations for ADHD evaluation and treatment in consideration of other aspects of the SCA medical and behavioral phenotype are provided. SN - 1536-7312 UR - https://www.unboundmedicine.com/medline/citation/22333574/Attention_deficit_hyperactivity_disorder_symptoms_in_children_and_adolescents_with_sex_chromosome_aneuploidy:_XXY_XXX_XYY_and_XXYY_ DB - PRIME DP - Unbound Medicine ER -