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Treatment of plaque-type psoriasis with the 308 nm excimer laser in combination with dithranol or calcipotriol.
Int J Hyperthermia. 2012; 28(2):184-90.IJ

Abstract

PURPOSE

The combination of excimer laser and topical treatment has not been studied in clinical trials. This within-patient comparison study evaluates the response rates of plaque-type psoriasis after treatment with topical only (dithranol or calcipotriol), laser only, and combination therapy with topical medication and laser.

MATERIALS AND METHODS

A total of 61 patients with psoriatic plaques located at symmetric body areas (PASI ≥ 6) were screened, 59 were enrolled, 54 completed treatment and 45 completed the 6 months follow-up. Treatments with the excimer laser were performed twice weekly until resolution or a maximum of 15 treatments. Each ointment was applied on one of the test lesions, which had to be at least 10 cm apart from each other. Efficacy was rated with a modified PASI score.

RESULTS

At the end of the treatment phase only one patient in both topical therapy regimens met the criteria of partial clearance (modified PASI ≤ 2). The combined therapies resulted in 23 cases of partial clearance in both treatment arms. Four areas treated with calcipotriol, respectively six areas treated with dithranol resulted in total clearance at the end of the treatment phase. The average reduction of modified PASI scores was higher in combination than in topical treatment alone (49.8% calcipotriol + excimer versus 22.9% calcipotriol, 49.7% dithranol + excimer versus 26.8% dithranol). After six months there was a total clearance of 30.5% dithranol + excimer.

CONCLUSIONS

Treatment of plaque-type psoriasis with laser in combination with topical treatment is a safe and effective therapy. The best long-term results can be obtained by the application of dithranol and excimer laser.

Authors+Show Affiliations

Department of Dermatology, Venereology and Allergology, University of Leipzig, Germany. christina.rogalski@medizin.uni-leipzig.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22335232

Citation

Rogalski, Christina, et al. "Treatment of Plaque-type Psoriasis With the 308 Nm Excimer Laser in Combination With Dithranol or Calcipotriol." International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, vol. 28, no. 2, 2012, pp. 184-90.
Rogalski C, Grunewald S, Schetschorke M, et al. Treatment of plaque-type psoriasis with the 308 nm excimer laser in combination with dithranol or calcipotriol. Int J Hyperthermia. 2012;28(2):184-90.
Rogalski, C., Grunewald, S., Schetschorke, M., Bodendorf, M. O., Kauer, F., Simon, J. C., & Paasch, U. (2012). Treatment of plaque-type psoriasis with the 308 nm excimer laser in combination with dithranol or calcipotriol. International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 28(2), 184-90. https://doi.org/10.3109/02656736.2011.647942
Rogalski C, et al. Treatment of Plaque-type Psoriasis With the 308 Nm Excimer Laser in Combination With Dithranol or Calcipotriol. Int J Hyperthermia. 2012;28(2):184-90. PubMed PMID: 22335232.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of plaque-type psoriasis with the 308 nm excimer laser in combination with dithranol or calcipotriol. AU - Rogalski,Christina, AU - Grunewald,Sonja, AU - Schetschorke,Mario, AU - Bodendorf,Marc Oliver, AU - Kauer,Friederike, AU - Simon,Jan Christoph, AU - Paasch,Uwe, PY - 2012/2/17/entrez PY - 2012/2/18/pubmed PY - 2012/6/20/medline SP - 184 EP - 90 JF - International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group JO - Int J Hyperthermia VL - 28 IS - 2 N2 - PURPOSE: The combination of excimer laser and topical treatment has not been studied in clinical trials. This within-patient comparison study evaluates the response rates of plaque-type psoriasis after treatment with topical only (dithranol or calcipotriol), laser only, and combination therapy with topical medication and laser. MATERIALS AND METHODS: A total of 61 patients with psoriatic plaques located at symmetric body areas (PASI ≥ 6) were screened, 59 were enrolled, 54 completed treatment and 45 completed the 6 months follow-up. Treatments with the excimer laser were performed twice weekly until resolution or a maximum of 15 treatments. Each ointment was applied on one of the test lesions, which had to be at least 10 cm apart from each other. Efficacy was rated with a modified PASI score. RESULTS: At the end of the treatment phase only one patient in both topical therapy regimens met the criteria of partial clearance (modified PASI ≤ 2). The combined therapies resulted in 23 cases of partial clearance in both treatment arms. Four areas treated with calcipotriol, respectively six areas treated with dithranol resulted in total clearance at the end of the treatment phase. The average reduction of modified PASI scores was higher in combination than in topical treatment alone (49.8% calcipotriol + excimer versus 22.9% calcipotriol, 49.7% dithranol + excimer versus 26.8% dithranol). After six months there was a total clearance of 30.5% dithranol + excimer. CONCLUSIONS: Treatment of plaque-type psoriasis with laser in combination with topical treatment is a safe and effective therapy. The best long-term results can be obtained by the application of dithranol and excimer laser. SN - 1464-5157 UR - https://www.unboundmedicine.com/medline/citation/22335232/Treatment_of_plaque_type_psoriasis_with_the_308_nm_excimer_laser_in_combination_with_dithranol_or_calcipotriol_ L2 - https://www.tandfonline.com/doi/full/10.3109/02656736.2011.647942 DB - PRIME DP - Unbound Medicine ER -