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Cutaneous changes in patients with chronic renal failure on hemodialysis.
Cutan Ocul Toxicol 2012; 31(4):286-91CO

Abstract

CONTEXT

A number of skin diseases can be observed in chronic renal failure (CRF). Their incidence have changed in different series.

OBJECTIVE

To compare the prevalence of cutaneous changes in CRF undergoing hemodialysis (HD) with healthy persons and to study the potential relationship with various parameters in the patients.

MATERIALS AND METHODS

The study comprised one hundred patients with CRF under regular HD as well as one hundred healthy control subjects of matched age and sex. Both groups were subjected to full history and thorough skin examination.

RESULTS

Numerous skin lesions (at least one in each patient) were detected in all patients examined. Of these patients, nail abnormalities were observed in 92%, xerosis in 87%, fungal infection in 68%, hyperpigmentation in 62%, pruritus in 51%, and paleness in 51%. The nail changes included absence of lunula (55%), half and half nail (51%), splinter hemorrhages (36%), subungual hyperkeratosis (34%), onychomycosis (31%), koilonychia (19%), and onycholysis (9%). Oral changes were oral candidiasis (50%), xerostomia (40%), angular cheilitis (27%), and ulcerative stomatitis (18%). Specific cutaneous findings such as acquired perforating dermatosis, pseudoporphyria cutanea tarda, calciphylaxis, calcinosis cutis, and nephrogenic fibrosing dermopathy were not detected in any of the patients. In our study, when the patients were evaluated on the relationship between xerosis and pruritus, pruritus was found to be significantly increased parallel to the increase in the severity of xerosis.

CONCLUSIONS

Xerosis and pruritus are common problems in HD-dependent patients. The early recognition of cutaneous signs can relieve suffering and decrease morbidity.

Authors+Show Affiliations

Department of Dermatology, Yenisehir State Hospital, Kahramanmaras, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22335460

Citation

Onelmis, Husniye, et al. "Cutaneous Changes in Patients With Chronic Renal Failure On Hemodialysis." Cutaneous and Ocular Toxicology, vol. 31, no. 4, 2012, pp. 286-91.
Onelmis H, Sener S, Sasmaz S, et al. Cutaneous changes in patients with chronic renal failure on hemodialysis. Cutan Ocul Toxicol. 2012;31(4):286-91.
Onelmis, H., Sener, S., Sasmaz, S., & Ozer, A. (2012). Cutaneous changes in patients with chronic renal failure on hemodialysis. Cutaneous and Ocular Toxicology, 31(4), pp. 286-91. doi:10.3109/15569527.2012.657726.
Onelmis H, et al. Cutaneous Changes in Patients With Chronic Renal Failure On Hemodialysis. Cutan Ocul Toxicol. 2012;31(4):286-91. PubMed PMID: 22335460.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cutaneous changes in patients with chronic renal failure on hemodialysis. AU - Onelmis,Husniye, AU - Sener,Serpil, AU - Sasmaz,Sezai, AU - Ozer,Ali, Y1 - 2012/02/15/ PY - 2012/2/17/entrez PY - 2012/2/18/pubmed PY - 2013/4/20/medline SP - 286 EP - 91 JF - Cutaneous and ocular toxicology JO - Cutan Ocul Toxicol VL - 31 IS - 4 N2 - CONTEXT: A number of skin diseases can be observed in chronic renal failure (CRF). Their incidence have changed in different series. OBJECTIVE: To compare the prevalence of cutaneous changes in CRF undergoing hemodialysis (HD) with healthy persons and to study the potential relationship with various parameters in the patients. MATERIALS AND METHODS: The study comprised one hundred patients with CRF under regular HD as well as one hundred healthy control subjects of matched age and sex. Both groups were subjected to full history and thorough skin examination. RESULTS: Numerous skin lesions (at least one in each patient) were detected in all patients examined. Of these patients, nail abnormalities were observed in 92%, xerosis in 87%, fungal infection in 68%, hyperpigmentation in 62%, pruritus in 51%, and paleness in 51%. The nail changes included absence of lunula (55%), half and half nail (51%), splinter hemorrhages (36%), subungual hyperkeratosis (34%), onychomycosis (31%), koilonychia (19%), and onycholysis (9%). Oral changes were oral candidiasis (50%), xerostomia (40%), angular cheilitis (27%), and ulcerative stomatitis (18%). Specific cutaneous findings such as acquired perforating dermatosis, pseudoporphyria cutanea tarda, calciphylaxis, calcinosis cutis, and nephrogenic fibrosing dermopathy were not detected in any of the patients. In our study, when the patients were evaluated on the relationship between xerosis and pruritus, pruritus was found to be significantly increased parallel to the increase in the severity of xerosis. CONCLUSIONS: Xerosis and pruritus are common problems in HD-dependent patients. The early recognition of cutaneous signs can relieve suffering and decrease morbidity. SN - 1556-9535 UR - https://www.unboundmedicine.com/medline/citation/22335460/Cutaneous_changes_in_patients_with_chronic_renal_failure_on_hemodialysis_ L2 - http://www.tandfonline.com/doi/full/10.3109/15569527.2012.657726 DB - PRIME DP - Unbound Medicine ER -