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Cutaneous changes in patients with chronic renal failure on hemodialysis.

Abstract

CONTEXT

A number of skin diseases can be observed in chronic renal failure (CRF). Their incidence have changed in different series.

OBJECTIVE

To compare the prevalence of cutaneous changes in CRF undergoing hemodialysis (HD) with healthy persons and to study the potential relationship with various parameters in the patients.

MATERIALS AND METHODS

The study comprised one hundred patients with CRF under regular HD as well as one hundred healthy control subjects of matched age and sex. Both groups were subjected to full history and thorough skin examination.

RESULTS

Numerous skin lesions (at least one in each patient) were detected in all patients examined. Of these patients, nail abnormalities were observed in 92%, xerosis in 87%, fungal infection in 68%, hyperpigmentation in 62%, pruritus in 51%, and paleness in 51%. The nail changes included absence of lunula (55%), half and half nail (51%), splinter hemorrhages (36%), subungual hyperkeratosis (34%), onychomycosis (31%), koilonychia (19%), and onycholysis (9%). Oral changes were oral candidiasis (50%), xerostomia (40%), angular cheilitis (27%), and ulcerative stomatitis (18%). Specific cutaneous findings such as acquired perforating dermatosis, pseudoporphyria cutanea tarda, calciphylaxis, calcinosis cutis, and nephrogenic fibrosing dermopathy were not detected in any of the patients. In our study, when the patients were evaluated on the relationship between xerosis and pruritus, pruritus was found to be significantly increased parallel to the increase in the severity of xerosis.

CONCLUSIONS

Xerosis and pruritus are common problems in HD-dependent patients. The early recognition of cutaneous signs can relieve suffering and decrease morbidity.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Dermatology, Yenisehir State Hospital, Kahramanmaras, Turkey.

    , ,

    Source

    Cutaneous and ocular toxicology 31:4 2012 Dec pg 286-91

    MeSH

    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Case-Control Studies
    Female
    Humans
    Incidence
    Kidney Failure, Chronic
    Male
    Middle Aged
    Renal Dialysis
    Skin Diseases
    Turkey
    Young Adult

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22335460

    Citation

    Onelmis, Husniye, et al. "Cutaneous Changes in Patients With Chronic Renal Failure On Hemodialysis." Cutaneous and Ocular Toxicology, vol. 31, no. 4, 2012, pp. 286-91.
    Onelmis H, Sener S, Sasmaz S, et al. Cutaneous changes in patients with chronic renal failure on hemodialysis. Cutan Ocul Toxicol. 2012;31(4):286-91.
    Onelmis, H., Sener, S., Sasmaz, S., & Ozer, A. (2012). Cutaneous changes in patients with chronic renal failure on hemodialysis. Cutaneous and Ocular Toxicology, 31(4), pp. 286-91. doi:10.3109/15569527.2012.657726.
    Onelmis H, et al. Cutaneous Changes in Patients With Chronic Renal Failure On Hemodialysis. Cutan Ocul Toxicol. 2012;31(4):286-91. PubMed PMID: 22335460.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cutaneous changes in patients with chronic renal failure on hemodialysis. AU - Onelmis,Husniye, AU - Sener,Serpil, AU - Sasmaz,Sezai, AU - Ozer,Ali, Y1 - 2012/02/15/ PY - 2012/2/17/entrez PY - 2012/2/18/pubmed PY - 2013/4/20/medline SP - 286 EP - 91 JF - Cutaneous and ocular toxicology JO - Cutan Ocul Toxicol VL - 31 IS - 4 N2 - CONTEXT: A number of skin diseases can be observed in chronic renal failure (CRF). Their incidence have changed in different series. OBJECTIVE: To compare the prevalence of cutaneous changes in CRF undergoing hemodialysis (HD) with healthy persons and to study the potential relationship with various parameters in the patients. MATERIALS AND METHODS: The study comprised one hundred patients with CRF under regular HD as well as one hundred healthy control subjects of matched age and sex. Both groups were subjected to full history and thorough skin examination. RESULTS: Numerous skin lesions (at least one in each patient) were detected in all patients examined. Of these patients, nail abnormalities were observed in 92%, xerosis in 87%, fungal infection in 68%, hyperpigmentation in 62%, pruritus in 51%, and paleness in 51%. The nail changes included absence of lunula (55%), half and half nail (51%), splinter hemorrhages (36%), subungual hyperkeratosis (34%), onychomycosis (31%), koilonychia (19%), and onycholysis (9%). Oral changes were oral candidiasis (50%), xerostomia (40%), angular cheilitis (27%), and ulcerative stomatitis (18%). Specific cutaneous findings such as acquired perforating dermatosis, pseudoporphyria cutanea tarda, calciphylaxis, calcinosis cutis, and nephrogenic fibrosing dermopathy were not detected in any of the patients. In our study, when the patients were evaluated on the relationship between xerosis and pruritus, pruritus was found to be significantly increased parallel to the increase in the severity of xerosis. CONCLUSIONS: Xerosis and pruritus are common problems in HD-dependent patients. The early recognition of cutaneous signs can relieve suffering and decrease morbidity. SN - 1556-9535 UR - https://www.unboundmedicine.com/medline/citation/22335460/Cutaneous_changes_in_patients_with_chronic_renal_failure_on_hemodialysis_ L2 - http://www.tandfonline.com/doi/full/10.3109/15569527.2012.657726 DB - PRIME DP - Unbound Medicine ER -