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Comparisons of large (Vaccinium macrocarpon Ait.) and small (Vaccinium oxycoccos L., Vaccinium vitis-idaea L.) cranberry in British Columbia by phytochemical determination, antioxidant potential, and metabolomic profiling with chemometric analysis.
Planta Med. 2012 Apr; 78(6):630-40.PM

Abstract

There is a long history of use and modern commercial importance of large and small cranberries in North America. The central objective of the current research was to characterize and compare the chemical composition of 2 west coast small cranberry species traditionally used (Vaccinium oxycoccos L. and Vaccinium vitis-idaea L.) with the commercially cultivated large cranberry (Vaccinium macrocarpon Ait.) indigenous to the east coast of North America. V. oxycoccos and V. macrocarpon contained the 5 major anthocyanins known in cranberry; however, the ratio of glycosylated peonidins to cyanidins varied, and V. vitis-idaea did not contain measurable amounts of glycosylated peonidins. Extracts of all three berries were found to contain serotonin, melatonin, and ascorbic acid. Antioxidant activity was not found to correlate with indolamine levels while anthocyanin content showed a negative correlation, and vitamin C content positively correlated. From the metabolomics profiles, 4624 compounds were found conserved across V. macrocarpon, V. oxycoccoS, and V. vitis-idaea with a total of approximately 8000-10 000 phytochemicals detected in each species. From significance analysis, it was found that 2 compounds in V. macrocarpoN, 3 in V. oxycoccos, and 5 in V. vitis-idaea were key to the characterization and differentiation of these cranberry metabolomes. Through multivariate modeling, differentiation of the species was observed, and univariate statistical analysis was employed to provide a quality assessment of the models developed for the metabolomics data.

Authors+Show Affiliations

Department of Chemistry, University of British Columbia, Okanagan Campus, Kelowna, British Columbia, Canada.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

22337317

Citation

Brown, Paula N., et al. "Comparisons of Large (Vaccinium Macrocarpon Ait.) and Small (Vaccinium Oxycoccos L., Vaccinium Vitis-idaea L.) Cranberry in British Columbia By Phytochemical Determination, Antioxidant Potential, and Metabolomic Profiling With Chemometric Analysis." Planta Medica, vol. 78, no. 6, 2012, pp. 630-40.
Brown PN, Turi CE, Shipley PR, et al. Comparisons of large (Vaccinium macrocarpon Ait.) and small (Vaccinium oxycoccos L., Vaccinium vitis-idaea L.) cranberry in British Columbia by phytochemical determination, antioxidant potential, and metabolomic profiling with chemometric analysis. Planta Med. 2012;78(6):630-40.
Brown, P. N., Turi, C. E., Shipley, P. R., & Murch, S. J. (2012). Comparisons of large (Vaccinium macrocarpon Ait.) and small (Vaccinium oxycoccos L., Vaccinium vitis-idaea L.) cranberry in British Columbia by phytochemical determination, antioxidant potential, and metabolomic profiling with chemometric analysis. Planta Medica, 78(6), 630-40. https://doi.org/10.1055/s-0031-1298239
Brown PN, et al. Comparisons of Large (Vaccinium Macrocarpon Ait.) and Small (Vaccinium Oxycoccos L., Vaccinium Vitis-idaea L.) Cranberry in British Columbia By Phytochemical Determination, Antioxidant Potential, and Metabolomic Profiling With Chemometric Analysis. Planta Med. 2012;78(6):630-40. PubMed PMID: 22337317.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparisons of large (Vaccinium macrocarpon Ait.) and small (Vaccinium oxycoccos L., Vaccinium vitis-idaea L.) cranberry in British Columbia by phytochemical determination, antioxidant potential, and metabolomic profiling with chemometric analysis. AU - Brown,Paula N, AU - Turi,Christina E, AU - Shipley,Paul R, AU - Murch,Susan J, Y1 - 2012/02/15/ PY - 2012/2/17/entrez PY - 2012/2/18/pubmed PY - 2012/12/10/medline SP - 630 EP - 40 JF - Planta medica JO - Planta Med. VL - 78 IS - 6 N2 - There is a long history of use and modern commercial importance of large and small cranberries in North America. The central objective of the current research was to characterize and compare the chemical composition of 2 west coast small cranberry species traditionally used (Vaccinium oxycoccos L. and Vaccinium vitis-idaea L.) with the commercially cultivated large cranberry (Vaccinium macrocarpon Ait.) indigenous to the east coast of North America. V. oxycoccos and V. macrocarpon contained the 5 major anthocyanins known in cranberry; however, the ratio of glycosylated peonidins to cyanidins varied, and V. vitis-idaea did not contain measurable amounts of glycosylated peonidins. Extracts of all three berries were found to contain serotonin, melatonin, and ascorbic acid. Antioxidant activity was not found to correlate with indolamine levels while anthocyanin content showed a negative correlation, and vitamin C content positively correlated. From the metabolomics profiles, 4624 compounds were found conserved across V. macrocarpon, V. oxycoccoS, and V. vitis-idaea with a total of approximately 8000-10 000 phytochemicals detected in each species. From significance analysis, it was found that 2 compounds in V. macrocarpoN, 3 in V. oxycoccos, and 5 in V. vitis-idaea were key to the characterization and differentiation of these cranberry metabolomes. Through multivariate modeling, differentiation of the species was observed, and univariate statistical analysis was employed to provide a quality assessment of the models developed for the metabolomics data. SN - 1439-0221 UR - https://www.unboundmedicine.com/medline/citation/22337317/Comparisons_of_large__Vaccinium_macrocarpon_Ait___and_small__Vaccinium_oxycoccos_L__Vaccinium_vitis_idaea_L___cranberry_in_British_Columbia_by_phytochemical_determination_antioxidant_potential_and_metabolomic_profiling_with_chemometric_analysis_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0031-1298239 DB - PRIME DP - Unbound Medicine ER -