TY - JOUR T1 - A liquid chromatography-electrospray tandem mass spectrometry method for the determination of antiarrhythmic drugs and their metabolites in forensic whole blood samples. A1 - Sørensen,Lambert K, PY - 2012/2/17/entrez PY - 2012/2/18/pubmed PY - 2012/6/23/medline SP - 116 EP - 22 JF - Journal of analytical toxicology JO - J Anal Toxicol VL - 36 IS - 2 N2 - A liquid chromatography-tandem mass spectrometry method, using pneumatically assisted electrospray ionization was developed for the determination of amiodarone, desethylamiodarone, propafenone, N-depropylpropafenone, 5-OH-propafenone, flecainide, and sotalol in human antemortem and postmortem whole blood. A mixture of methanol and acetonitrile was used to extract the samples, and the clear extracts obtained from the protein precipitation were injected directly onto an ethyl-linked phenyl LC column. The isotope dilution technique was applied for quantitative analysis. The relative intralaboratory reproducibility standard deviations were 5-9% at a concentration range of 1-5 mg/L and 9-12% at a concentration of 0.1 mg/L. The mean true recoveries were greater than 91% in the concentration range of 0.05-5 mg/L. The detection limits were in the range of 8-18 µg/L. SN - 1945-2403 UR - https://www.unboundmedicine.com/medline/citation/22337781/A_liquid_chromatography_electrospray_tandem_mass_spectrometry_method_for_the_determination_of_antiarrhythmic_drugs_and_their_metabolites_in_forensic_whole_blood_samples_ L2 - https://academic.oup.com/jat/article-lookup/doi/10.1093/jat/bkr021 DB - PRIME DP - Unbound Medicine ER -