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Analytical evaluation of four on-site oral fluid drug testing devices.
J Anal Toxicol. 2012 Mar; 36(2):136-40.JA

Abstract

The use of oral fluid (OF) as an alternative matrix for the detection of drugs of abuse has increased over the last decade, leading to the need for a rapid, simple, and reliable on-site OF testing device. Four on-site OF drug testing devices (Dräger DrugTest 5000, Cozart DDS, Mavand Rapid STAT, and Innovacon OrAlert) were evaluated on 408 volunteers at drug treatment centers. UPLC-MS-MS results were used as reference to determine sensitivity, specificity and accuracy for each device, applying Belgian legal confirmation cutoffs for benzoylecgonine, cocaine, and THC (10 ng/mL); morphine and 6-acetylmorphine (5 ng/mL); and amphetamine and 3,4-methylenedioxymethylamphetamine (25 ng/mL). Sensitivity for cocaine was 50%, 50%, 27%, and 11% for DrugTest, OrAlert, Rapid STAT, and DDS 806, respectively. For opiates, sensitivities were 84%, 73%, 77%, and 65%, respectively. For THC, the sensitivities were 81%, 23%, 43%, and 28%, respectively. For amphetamines, the sensitivities were 75%, 33%, 17%, and 67%, respectively. Specificity was >88% for opiates and THC, > 90% for amphetamines, and > 97% for cocaine. All tests showed good specificity. DrugTest had the highest sensitivity, although it was still low for some analytes.

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Authors+Show Affiliations

Vanstechelman S
Department of Clinical Chemistry, Microbiology, and Immunology, Ghent University, De Pintelaan 185, 9000 Ghent, Belgium. Sylvie.Vanstechelman@Ugent.be
Isalberti C
No affiliation info available
Van der Linden T
No affiliation info available
Pil K
No affiliation info available
Legrand SA
No affiliation info available
Verstraete AG
No affiliation info available

MeSH

AmphetamineChromatography, LiquidCocaineDronabinolHumansMethamphetamineMorphine DerivativesReproducibility of ResultsSalivaSensitivity and SpecificitySubstance Abuse DetectionSubstance-Related DisordersTandem Mass Spectrometry

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22337784

Citation

Vanstechelman, Sylvie, et al. "Analytical Evaluation of Four On-site Oral Fluid Drug Testing Devices." Journal of Analytical Toxicology, vol. 36, no. 2, 2012, pp. 136-40.
Vanstechelman S, Isalberti C, Van der Linden T, et al. Analytical evaluation of four on-site oral fluid drug testing devices. J Anal Toxicol. 2012;36(2):136-40.
Vanstechelman, S., Isalberti, C., Van der Linden, T., Pil, K., Legrand, S. A., & Verstraete, A. G. (2012). Analytical evaluation of four on-site oral fluid drug testing devices. Journal of Analytical Toxicology, 36(2), 136-40. https://doi.org/10.1093/jat/bkr016
Vanstechelman S, et al. Analytical Evaluation of Four On-site Oral Fluid Drug Testing Devices. J Anal Toxicol. 2012;36(2):136-40. PubMed PMID: 22337784.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analytical evaluation of four on-site oral fluid drug testing devices. AU - Vanstechelman,Sylvie, AU - Isalberti,Cristina, AU - Van der Linden,Trudy, AU - Pil,Kristof, AU - Legrand,Sara-Ann, AU - Verstraete,Alain G, PY - 2012/2/17/entrez PY - 2012/2/18/pubmed PY - 2012/6/23/medline SP - 136 EP - 40 JF - Journal of analytical toxicology JO - J Anal Toxicol VL - 36 IS - 2 N2 - The use of oral fluid (OF) as an alternative matrix for the detection of drugs of abuse has increased over the last decade, leading to the need for a rapid, simple, and reliable on-site OF testing device. Four on-site OF drug testing devices (Dräger DrugTest 5000, Cozart DDS, Mavand Rapid STAT, and Innovacon OrAlert) were evaluated on 408 volunteers at drug treatment centers. UPLC-MS-MS results were used as reference to determine sensitivity, specificity and accuracy for each device, applying Belgian legal confirmation cutoffs for benzoylecgonine, cocaine, and THC (10 ng/mL); morphine and 6-acetylmorphine (5 ng/mL); and amphetamine and 3,4-methylenedioxymethylamphetamine (25 ng/mL). Sensitivity for cocaine was 50%, 50%, 27%, and 11% for DrugTest, OrAlert, Rapid STAT, and DDS 806, respectively. For opiates, sensitivities were 84%, 73%, 77%, and 65%, respectively. For THC, the sensitivities were 81%, 23%, 43%, and 28%, respectively. For amphetamines, the sensitivities were 75%, 33%, 17%, and 67%, respectively. Specificity was >88% for opiates and THC, > 90% for amphetamines, and > 97% for cocaine. All tests showed good specificity. DrugTest had the highest sensitivity, although it was still low for some analytes. SN - 1945-2403 UR - https://www.unboundmedicine.com/medline/citation/22337784/Analytical_evaluation_of_four_on_site_oral_fluid_drug_testing_devices_ L2 - https://academic.oup.com/jat/article-lookup/doi/10.1093/jat/bkr016 DB - PRIME DP - Unbound Medicine ER -