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Vitamin D insufficiency and mild cognitive impairment: cross-sectional association.

Abstract

BACKGROUND

  Low serum 25-hydroxyvitamin D (25OHD) concentrations have been associated with dementia. The association with mild cognitive impairment (MCI) has not yet been explored. Our aim was to examine the association between vitamin D status and MCI status amongst older community-dwellers with subjective memory complaint.

METHODS

  Ninety-five non-demented Caucasian community-dwellers with subjective memory complaint (mean, 71.1 ± 6.4 years; 54.7% women) included in the Gait and Alzheimer Interaction Tracking (GAIT) study were categorized into two groups according to Winblad et al. consensus criteria [i.e., subjects with MCI or cognitively healthy individuals (CHI)]. Serum 25OHD concentration was divided into quartiles, the fourth quartile corresponding to the highest 25OHD concentration. The cross-sectional associations between 25OHD concentrations and MCI were modeled using logistic regressions. Age, gender, body mass index, number of comorbidities, education level, Mini-Mental State Examination score, Frontal Assessment Battery score, Geriatric Depression Scale score, creatinine clearance, and season tested were considered as potential confounders.

RESULTS

  Compared to CHI, patients with MCI (n = 43; mean, 71.4 ± 5.6 years; 34.9% women) had lower mean serum 25OHD concentrations (P = 0.006) and belonged more often to the lower quartiles compared to the highest quartile (P = 0.03). Increased serum 25OHD concentration was associated with a lower risk of MCI [adjusted odds ratio (OR) = 0.96, P = 0.002]. Accordingly, lower quartiles of 25OHD were positively associated with MCI whilst using the highest quartile as reference (adjusted OR = 25.46, P = 0.002 for the first quartile; adjusted OR = 6.89, P = 0.03 for the second quartile; and adjusted OR = 10.29, P = 0.02 for the third quartile).

CONCLUSIONS

  Low 25OHD concentrations were associated with MCI status in older non-demented community-dwellers with subjective memory complaint.

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  • Authors+Show Affiliations

    ,

    Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital, Angers Cedex 9, France. ceannweiler@chu-angers.fr

    , , , ,

    Source

    European journal of neurology 19:7 2012 Jul pg 1023-9

    MeSH

    Aged
    Aged, 80 and over
    Biomarkers
    Cognitive Dysfunction
    Cross-Sectional Studies
    Female
    Humans
    Male
    Vitamin D
    Vitamin D Deficiency

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    22339714

    Citation

    Annweiler, C, et al. "Vitamin D Insufficiency and Mild Cognitive Impairment: Cross-sectional Association." European Journal of Neurology, vol. 19, no. 7, 2012, pp. 1023-9.
    Annweiler C, Fantino B, Schott AM, et al. Vitamin D insufficiency and mild cognitive impairment: cross-sectional association. Eur J Neurol. 2012;19(7):1023-9.
    Annweiler, C., Fantino, B., Schott, A. M., Krolak-Salmon, P., Allali, G., & Beauchet, O. (2012). Vitamin D insufficiency and mild cognitive impairment: cross-sectional association. European Journal of Neurology, 19(7), pp. 1023-9. doi:10.1111/j.1468-1331.2012.03675.x.
    Annweiler C, et al. Vitamin D Insufficiency and Mild Cognitive Impairment: Cross-sectional Association. Eur J Neurol. 2012;19(7):1023-9. PubMed PMID: 22339714.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vitamin D insufficiency and mild cognitive impairment: cross-sectional association. AU - Annweiler,C, AU - Fantino,B, AU - Schott,A M, AU - Krolak-Salmon,P, AU - Allali,G, AU - Beauchet,O, Y1 - 2012/02/16/ PY - 2012/2/21/entrez PY - 2012/2/22/pubmed PY - 2013/5/1/medline SP - 1023 EP - 9 JF - European journal of neurology JO - Eur. J. Neurol. VL - 19 IS - 7 N2 - BACKGROUND:   Low serum 25-hydroxyvitamin D (25OHD) concentrations have been associated with dementia. The association with mild cognitive impairment (MCI) has not yet been explored. Our aim was to examine the association between vitamin D status and MCI status amongst older community-dwellers with subjective memory complaint. METHODS:   Ninety-five non-demented Caucasian community-dwellers with subjective memory complaint (mean, 71.1 ± 6.4 years; 54.7% women) included in the Gait and Alzheimer Interaction Tracking (GAIT) study were categorized into two groups according to Winblad et al. consensus criteria [i.e., subjects with MCI or cognitively healthy individuals (CHI)]. Serum 25OHD concentration was divided into quartiles, the fourth quartile corresponding to the highest 25OHD concentration. The cross-sectional associations between 25OHD concentrations and MCI were modeled using logistic regressions. Age, gender, body mass index, number of comorbidities, education level, Mini-Mental State Examination score, Frontal Assessment Battery score, Geriatric Depression Scale score, creatinine clearance, and season tested were considered as potential confounders. RESULTS:   Compared to CHI, patients with MCI (n = 43; mean, 71.4 ± 5.6 years; 34.9% women) had lower mean serum 25OHD concentrations (P = 0.006) and belonged more often to the lower quartiles compared to the highest quartile (P = 0.03). Increased serum 25OHD concentration was associated with a lower risk of MCI [adjusted odds ratio (OR) = 0.96, P = 0.002]. Accordingly, lower quartiles of 25OHD were positively associated with MCI whilst using the highest quartile as reference (adjusted OR = 25.46, P = 0.002 for the first quartile; adjusted OR = 6.89, P = 0.03 for the second quartile; and adjusted OR = 10.29, P = 0.02 for the third quartile). CONCLUSIONS:   Low 25OHD concentrations were associated with MCI status in older non-demented community-dwellers with subjective memory complaint. SN - 1468-1331 UR - https://www.unboundmedicine.com/medline/citation/22339714/Vitamin_D_insufficiency_and_mild_cognitive_impairment:_cross_sectional_association_ L2 - https://doi.org/10.1111/j.1468-1331.2012.03675.x DB - PRIME DP - Unbound Medicine ER -