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Impact of statin therapy on plaque characteristics as assessed by serial OCT, grayscale and integrated backscatter-IVUS.
JACC Cardiovasc Imaging. 2012 Feb; 5(2):169-77.JC

Abstract

OBJECTIVES

The purpose of this study was to evaluate the effect of statin treatment on coronary plaque composition and morphology by optical coherence tomography (OCT), grayscale and integrated backscatter (IB) intravascular ultrasound (IVUS) imaging.

BACKGROUND

Although previous studies have demonstrated that statins substantially improve cardiac mortality, their precise effect on the lipid content and fibrous cap thickness of atherosclerotic coronary lesions is less clear. While IVUS lacks the spatial resolution to accurately assess fibrous cap thickness, OCT lacks the penetration of IVUS. We used a combination of OCT, grayscale and IB-IVUS to comprehensively assess the impact of pitavastatin on plaque characteristics.

METHODS

Prospective serial OCT, grayscale and IB-IVUS of nontarget lesions was performed in 42 stable angina patients undergoing elective coronary intervention. Of these, 26 received 4 mg pitavastatin after the baseline study; 16 subjects who refused statin treatment were followed with dietary modification alone. Follow-up imaging was performed after a median interval of 9 months.

RESULTS

Grayscale IVUS revealed that in the statin-treated patients, percent plaque volume index was significantly reduced over time (48.5 ± 10.4%, 42.0 ± 11.1%; p = 0.033), whereas no change was observed in the diet-only patients (48.7 ± 10.4%, 50.4 ± 11.8%; p = NS). IB-IVUS identified significant reductions in the percentage lipid volume index over time (34.9 ± 12.2%, 28.2 ± 7.5%; p = 0.020); no change was observed in the diet-treated group (31.0 ± 10.7%, 33.8 ± 12.4%; p = NS). While OCT demonstrated a significant increase in fibrous cap thickness (140 ± 42 μm, 189 ± 46 μm; p = 0.001), such changes were not observed in the diet-only group (140 ± 35 μm, 142 ± 36 μm; p = NS). Differences in the changes in the percentage lipid volume index (-6.8 ± 8.0% vs. 2.8 ± 9.9%, p = 0.031) and fibrous cap thickness (52 ± 32 μm vs. 2 ± 22 μm, p < 0.001) over time between the pitavastatin and diet groups were highly significant.

CONCLUSIONS

Statin treatment induces favorable plaque morphologic changes with an increase in fibrous cap thickness, and decreases in both percentage plaque and lipid volume indexes.

Authors+Show Affiliations

Department of Cardiology, Fujita Health University Hospital, Kutsukake, Toyoake, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22340823

Citation

Hattori, Kousuke, et al. "Impact of Statin Therapy On Plaque Characteristics as Assessed By Serial OCT, Grayscale and Integrated Backscatter-IVUS." JACC. Cardiovascular Imaging, vol. 5, no. 2, 2012, pp. 169-77.
Hattori K, Ozaki Y, Ismail TF, et al. Impact of statin therapy on plaque characteristics as assessed by serial OCT, grayscale and integrated backscatter-IVUS. JACC Cardiovasc Imaging. 2012;5(2):169-77.
Hattori, K., Ozaki, Y., Ismail, T. F., Okumura, M., Naruse, H., Kan, S., Ishikawa, M., Kawai, T., Ohta, M., Kawai, H., Hashimoto, T., Takagi, Y., Ishii, J., Serruys, P. W., & Narula, J. (2012). Impact of statin therapy on plaque characteristics as assessed by serial OCT, grayscale and integrated backscatter-IVUS. JACC. Cardiovascular Imaging, 5(2), 169-77. https://doi.org/10.1016/j.jcmg.2011.11.012
Hattori K, et al. Impact of Statin Therapy On Plaque Characteristics as Assessed By Serial OCT, Grayscale and Integrated Backscatter-IVUS. JACC Cardiovasc Imaging. 2012;5(2):169-77. PubMed PMID: 22340823.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of statin therapy on plaque characteristics as assessed by serial OCT, grayscale and integrated backscatter-IVUS. AU - Hattori,Kousuke, AU - Ozaki,Yukio, AU - Ismail,Tevfik F, AU - Okumura,Masanori, AU - Naruse,Hiroyuki, AU - Kan,Shino, AU - Ishikawa,Makoto, AU - Kawai,Tomoko, AU - Ohta,Masaya, AU - Kawai,Hideki, AU - Hashimoto,Tousei, AU - Takagi,Yasushi, AU - Ishii,Junichi, AU - Serruys,Patrick W, AU - Narula,Jagat, PY - 2011/05/09/received PY - 2011/10/18/revised PY - 2011/11/27/accepted PY - 2012/2/21/entrez PY - 2012/2/22/pubmed PY - 2012/6/12/medline SP - 169 EP - 77 JF - JACC. Cardiovascular imaging JO - JACC Cardiovasc Imaging VL - 5 IS - 2 N2 - OBJECTIVES: The purpose of this study was to evaluate the effect of statin treatment on coronary plaque composition and morphology by optical coherence tomography (OCT), grayscale and integrated backscatter (IB) intravascular ultrasound (IVUS) imaging. BACKGROUND: Although previous studies have demonstrated that statins substantially improve cardiac mortality, their precise effect on the lipid content and fibrous cap thickness of atherosclerotic coronary lesions is less clear. While IVUS lacks the spatial resolution to accurately assess fibrous cap thickness, OCT lacks the penetration of IVUS. We used a combination of OCT, grayscale and IB-IVUS to comprehensively assess the impact of pitavastatin on plaque characteristics. METHODS: Prospective serial OCT, grayscale and IB-IVUS of nontarget lesions was performed in 42 stable angina patients undergoing elective coronary intervention. Of these, 26 received 4 mg pitavastatin after the baseline study; 16 subjects who refused statin treatment were followed with dietary modification alone. Follow-up imaging was performed after a median interval of 9 months. RESULTS: Grayscale IVUS revealed that in the statin-treated patients, percent plaque volume index was significantly reduced over time (48.5 ± 10.4%, 42.0 ± 11.1%; p = 0.033), whereas no change was observed in the diet-only patients (48.7 ± 10.4%, 50.4 ± 11.8%; p = NS). IB-IVUS identified significant reductions in the percentage lipid volume index over time (34.9 ± 12.2%, 28.2 ± 7.5%; p = 0.020); no change was observed in the diet-treated group (31.0 ± 10.7%, 33.8 ± 12.4%; p = NS). While OCT demonstrated a significant increase in fibrous cap thickness (140 ± 42 μm, 189 ± 46 μm; p = 0.001), such changes were not observed in the diet-only group (140 ± 35 μm, 142 ± 36 μm; p = NS). Differences in the changes in the percentage lipid volume index (-6.8 ± 8.0% vs. 2.8 ± 9.9%, p = 0.031) and fibrous cap thickness (52 ± 32 μm vs. 2 ± 22 μm, p < 0.001) over time between the pitavastatin and diet groups were highly significant. CONCLUSIONS: Statin treatment induces favorable plaque morphologic changes with an increase in fibrous cap thickness, and decreases in both percentage plaque and lipid volume indexes. SN - 1876-7591 UR - https://www.unboundmedicine.com/medline/citation/22340823/Impact_of_statin_therapy_on_plaque_characteristics_as_assessed_by_serial_OCT_grayscale_and_integrated_backscatter_IVUS_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1936-878X(11)00891-6 DB - PRIME DP - Unbound Medicine ER -