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Scrub typhus in children at a tertiary hospital in southern India: clinical profile and complications.
J Infect Public Health. 2012 Mar; 5(1):82-8.JI

Abstract

OBJECTIVE

To study the clinical profile of and complications in children with scrub typhus.

DESIGN

Prospective observational study.

SETTING

Tertiary care hospital.

METHODS

Children up to 12 years of age who had a fever for more than five days without an identifiable infection were included. All children who were suspected of having rickettsial infections were defined as having scrub typhus if they had a positive Weil-Felix test result (OX-K 1:80 or more) and one or more of the following clinical features (after exclusion of other diagnoses): rash, edema, hepatosplenomegaly, lymphadenopathy, an eschar, and a tick bite or tick exposure.

RESULTS

Thirty-five children were diagnosed with scrub typhus between February 2010 and February 2011. The age of the patients ranged from 1.5 to 12 years. Edema, crackles/rhonchi, hepatomegaly and hypotension were encountered in 60%, 23%, 91% and 34% of patients, respectively. An eschar was observed in 11% of the cases. Complications included myocarditis with cardiogenic shock in 34% of the cases and acute kidney injury in 20% of the cases. Anicteric hepatitis and thrombocytopenia were observed in 31% and 61% of cases, respectively. One patient died.

CONCLUSIONS

High incidences of myocarditis and acute kidney injury were observed, which indicates that the children were treated at a late stage of the disease. Clinicians should be cognizant that myocarditis and acute kidney injury are serious manifestations of pediatric scrub typhus.

Authors+Show Affiliations

Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22341847

Citation

Kumar, Manish, et al. "Scrub Typhus in Children at a Tertiary Hospital in Southern India: Clinical Profile and Complications." Journal of Infection and Public Health, vol. 5, no. 1, 2012, pp. 82-8.
Kumar M, Krishnamurthy S, Delhikumar CG, et al. Scrub typhus in children at a tertiary hospital in southern India: clinical profile and complications. J Infect Public Health. 2012;5(1):82-8.
Kumar, M., Krishnamurthy, S., Delhikumar, C. G., Narayanan, P., Biswal, N., & Srinivasan, S. (2012). Scrub typhus in children at a tertiary hospital in southern India: clinical profile and complications. Journal of Infection and Public Health, 5(1), 82-8. https://doi.org/10.1016/j.jiph.2011.11.001
Kumar M, et al. Scrub Typhus in Children at a Tertiary Hospital in Southern India: Clinical Profile and Complications. J Infect Public Health. 2012;5(1):82-8. PubMed PMID: 22341847.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Scrub typhus in children at a tertiary hospital in southern India: clinical profile and complications. AU - Kumar,Manish, AU - Krishnamurthy,Sriram, AU - Delhikumar,C G, AU - Narayanan,Parameswaran, AU - Biswal,Niranjan, AU - Srinivasan,Sadagopan, Y1 - 2011/12/24/ PY - 2011/07/22/received PY - 2011/09/28/revised PY - 2011/11/02/accepted PY - 2012/2/21/entrez PY - 2012/2/22/pubmed PY - 2012/4/7/medline SP - 82 EP - 8 JF - Journal of infection and public health JO - J Infect Public Health VL - 5 IS - 1 N2 - OBJECTIVE: To study the clinical profile of and complications in children with scrub typhus. DESIGN: Prospective observational study. SETTING: Tertiary care hospital. METHODS: Children up to 12 years of age who had a fever for more than five days without an identifiable infection were included. All children who were suspected of having rickettsial infections were defined as having scrub typhus if they had a positive Weil-Felix test result (OX-K 1:80 or more) and one or more of the following clinical features (after exclusion of other diagnoses): rash, edema, hepatosplenomegaly, lymphadenopathy, an eschar, and a tick bite or tick exposure. RESULTS: Thirty-five children were diagnosed with scrub typhus between February 2010 and February 2011. The age of the patients ranged from 1.5 to 12 years. Edema, crackles/rhonchi, hepatomegaly and hypotension were encountered in 60%, 23%, 91% and 34% of patients, respectively. An eschar was observed in 11% of the cases. Complications included myocarditis with cardiogenic shock in 34% of the cases and acute kidney injury in 20% of the cases. Anicteric hepatitis and thrombocytopenia were observed in 31% and 61% of cases, respectively. One patient died. CONCLUSIONS: High incidences of myocarditis and acute kidney injury were observed, which indicates that the children were treated at a late stage of the disease. Clinicians should be cognizant that myocarditis and acute kidney injury are serious manifestations of pediatric scrub typhus. SN - 1876-035X UR - https://www.unboundmedicine.com/medline/citation/22341847/Scrub_typhus_in_children_at_a_tertiary_hospital_in_southern_India:_clinical_profile_and_complications_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1876-0341(11)00134-1 DB - PRIME DP - Unbound Medicine ER -