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In vitro and in vivo antioxidant activity of the ethanolic extract from Meconopsis quintuplinervia.
J Ethnopharmacol. 2012 May 07; 141(1):104-10.JE

Abstract

AIMS OF THE STUDY

Meconopsis quintuplinervia, a medicinal herb endemic to the Tibetan region, is used to treat hepatitis. The aim of this study is to evaluate the antioxidant potential of the ethanolic extract of this herb using different assays.

MATERIALS AND METHODS

The antioxidant capacity of Meconopsis quintuplinervia was investigated using various established in vitro systems. An in vivo study of carbon tetrachloride (CCl(4))-induced antioxidant activity in mice was also conducted by examining the levels of malondialdehyde (MDA) and the activities of antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH).

RESULTS

The extract showed strong in vitro antioxidant ability. In the in vivo study, CCl(4)-induced oxidative stress caused significant decreases in the SOD, CAT, and GSH levels and a significant increase in the MDA level, most of which were significantly reversed (except for SOD in the liver.) by treatment with the extract and standard Vitamin E.

CONCLUSION

This study clearly indicates that the ethanolic extract of Meconopsis quintuplinervia is a valuable source of natural antioxidants. These findings provide scientific support for the traditional use of this herb as a Tibetan medicine for liver diseases.

Authors+Show Affiliations

Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University), Ministry of Education, and Institute of TCM & Natural Products, Wuhan University School of Pharmaceutical Sciences, Wuhan 430071, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22343365

Citation

He, Jingsheng, et al. "In Vitro and in Vivo Antioxidant Activity of the Ethanolic Extract From Meconopsis Quintuplinervia." Journal of Ethnopharmacology, vol. 141, no. 1, 2012, pp. 104-10.
He J, Huang B, Ban X, et al. In vitro and in vivo antioxidant activity of the ethanolic extract from Meconopsis quintuplinervia. J Ethnopharmacol. 2012;141(1):104-10.
He, J., Huang, B., Ban, X., Tian, J., Zhu, L., & Wang, Y. (2012). In vitro and in vivo antioxidant activity of the ethanolic extract from Meconopsis quintuplinervia. Journal of Ethnopharmacology, 141(1), 104-10. https://doi.org/10.1016/j.jep.2012.02.006
He J, et al. In Vitro and in Vivo Antioxidant Activity of the Ethanolic Extract From Meconopsis Quintuplinervia. J Ethnopharmacol. 2012 May 7;141(1):104-10. PubMed PMID: 22343365.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro and in vivo antioxidant activity of the ethanolic extract from Meconopsis quintuplinervia. AU - He,Jingsheng, AU - Huang,Bo, AU - Ban,Xiaoquan, AU - Tian,Jun, AU - Zhu,Ling, AU - Wang,Youwei, Y1 - 2012/02/15/ PY - 2011/09/07/received PY - 2012/02/04/revised PY - 2012/02/06/accepted PY - 2012/2/21/entrez PY - 2012/2/22/pubmed PY - 2012/8/11/medline SP - 104 EP - 10 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 141 IS - 1 N2 - AIMS OF THE STUDY: Meconopsis quintuplinervia, a medicinal herb endemic to the Tibetan region, is used to treat hepatitis. The aim of this study is to evaluate the antioxidant potential of the ethanolic extract of this herb using different assays. MATERIALS AND METHODS: The antioxidant capacity of Meconopsis quintuplinervia was investigated using various established in vitro systems. An in vivo study of carbon tetrachloride (CCl(4))-induced antioxidant activity in mice was also conducted by examining the levels of malondialdehyde (MDA) and the activities of antioxidant enzymes, including superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH). RESULTS: The extract showed strong in vitro antioxidant ability. In the in vivo study, CCl(4)-induced oxidative stress caused significant decreases in the SOD, CAT, and GSH levels and a significant increase in the MDA level, most of which were significantly reversed (except for SOD in the liver.) by treatment with the extract and standard Vitamin E. CONCLUSION: This study clearly indicates that the ethanolic extract of Meconopsis quintuplinervia is a valuable source of natural antioxidants. These findings provide scientific support for the traditional use of this herb as a Tibetan medicine for liver diseases. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/22343365/In_vitro_and_in_vivo_antioxidant_activity_of_the_ethanolic_extract_from_Meconopsis_quintuplinervia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(12)00087-6 DB - PRIME DP - Unbound Medicine ER -