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Metabolic effects of aerobic training and resistance training in type 2 diabetic subjects: a randomized controlled trial (the RAED2 study).
Diabetes Care 2012; 35(4):676-82DC

Abstract

OBJECTIVE

To assess differences between the effects of aerobic and resistance training on HbA(1c) (primary outcome) and several metabolic risk factors in subjects with type 2 diabetes, and to identify predictors of exercise-induced metabolic improvement.

RESEARCH DESIGN AND METHODS

Type 2 diabetic patients (n = 40) were randomly assigned to aerobic training or resistance training. Before and after 4 months of intervention, metabolic phenotypes (including HbA(1c), glucose clamp-measured insulin sensitivity, and oral glucose tolerance test-assessed β-cell function), body composition by dual-energy X-ray absorptiometry, visceral (VAT) and subcutaneous (SAT) adipose tissue by magnetic resonance imaging, cardiorespiratory fitness, and muscular strength were measured.

RESULTS

After training, increase in peak oxygen consumption (V(O(2peak))) was greater in the aerobic group (time-by-group interaction P = 0.045), whereas increase in strength was greater in the resistance group (time-by-group interaction P < 0.0001). HbA(1c) was similarly reduced in both groups (-0.40% [95% CI -0.61 to -0.18] vs. -0.35% [-0.59 to -0.10], respectively). Total and truncal fat, VAT, and SAT were also similarly reduced in both groups, whereas insulin sensitivity and lean limb mass were similarly increased. β-Cell function showed no significant changes. In multivariate analyses, improvement in HbA(1c) after training was independently predicted by baseline HbA(1c) and by changes in V(O(2peak)) and truncal fat.

CONCLUSIONS

Resistance training, similarly to aerobic training, improves metabolic features and insulin sensitivity and reduces abdominal fat in type 2 diabetic patients. Changes after training in V(O(2peak)) and truncal fat may be primary determinants of exercise-induced metabolic improvement.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22344613

Citation

Bacchi, Elisabetta, et al. "Metabolic Effects of Aerobic Training and Resistance Training in Type 2 Diabetic Subjects: a Randomized Controlled Trial (the RAED2 Study)." Diabetes Care, vol. 35, no. 4, 2012, pp. 676-82.
Bacchi E, Negri C, Zanolin ME, et al. Metabolic effects of aerobic training and resistance training in type 2 diabetic subjects: a randomized controlled trial (the RAED2 study). Diabetes Care. 2012;35(4):676-82.
Bacchi, E., Negri, C., Zanolin, M. E., Milanese, C., Faccioli, N., Trombetta, M., ... Moghetti, P. (2012). Metabolic effects of aerobic training and resistance training in type 2 diabetic subjects: a randomized controlled trial (the RAED2 study). Diabetes Care, 35(4), pp. 676-82. doi:10.2337/dc11-1655.
Bacchi E, et al. Metabolic Effects of Aerobic Training and Resistance Training in Type 2 Diabetic Subjects: a Randomized Controlled Trial (the RAED2 Study). Diabetes Care. 2012;35(4):676-82. PubMed PMID: 22344613.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic effects of aerobic training and resistance training in type 2 diabetic subjects: a randomized controlled trial (the RAED2 study). AU - Bacchi,Elisabetta, AU - Negri,Carlo, AU - Zanolin,Maria Elisabetta, AU - Milanese,Chiara, AU - Faccioli,Niccolò, AU - Trombetta,Maddalena, AU - Zoppini,Giacomo, AU - Cevese,Antonio, AU - Bonadonna,Riccardo C, AU - Schena,Federico, AU - Bonora,Enzo, AU - Lanza,Massimo, AU - Moghetti,Paolo, Y1 - 2012/02/16/ PY - 2012/2/21/entrez PY - 2012/2/22/pubmed PY - 2012/8/10/medline SP - 676 EP - 82 JF - Diabetes care JO - Diabetes Care VL - 35 IS - 4 N2 - OBJECTIVE: To assess differences between the effects of aerobic and resistance training on HbA(1c) (primary outcome) and several metabolic risk factors in subjects with type 2 diabetes, and to identify predictors of exercise-induced metabolic improvement. RESEARCH DESIGN AND METHODS: Type 2 diabetic patients (n = 40) were randomly assigned to aerobic training or resistance training. Before and after 4 months of intervention, metabolic phenotypes (including HbA(1c), glucose clamp-measured insulin sensitivity, and oral glucose tolerance test-assessed β-cell function), body composition by dual-energy X-ray absorptiometry, visceral (VAT) and subcutaneous (SAT) adipose tissue by magnetic resonance imaging, cardiorespiratory fitness, and muscular strength were measured. RESULTS: After training, increase in peak oxygen consumption (V(O(2peak))) was greater in the aerobic group (time-by-group interaction P = 0.045), whereas increase in strength was greater in the resistance group (time-by-group interaction P < 0.0001). HbA(1c) was similarly reduced in both groups (-0.40% [95% CI -0.61 to -0.18] vs. -0.35% [-0.59 to -0.10], respectively). Total and truncal fat, VAT, and SAT were also similarly reduced in both groups, whereas insulin sensitivity and lean limb mass were similarly increased. β-Cell function showed no significant changes. In multivariate analyses, improvement in HbA(1c) after training was independently predicted by baseline HbA(1c) and by changes in V(O(2peak)) and truncal fat. CONCLUSIONS: Resistance training, similarly to aerobic training, improves metabolic features and insulin sensitivity and reduces abdominal fat in type 2 diabetic patients. Changes after training in V(O(2peak)) and truncal fat may be primary determinants of exercise-induced metabolic improvement. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/22344613/Metabolic_effects_of_aerobic_training_and_resistance_training_in_type_2_diabetic_subjects:_a_randomized_controlled_trial__the_RAED2_study__ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&amp;pmid=22344613 DB - PRIME DP - Unbound Medicine ER -