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Sex-dependent novelty response in neurexin-1α mutant mice.
PLoS One. 2012; 7(2):e31503.Plos

Abstract

Neurexin-1 alpha (NRXN1α) belongs to the family of cell adhesion molecules (CAMs), which are involved in the formation of neuronal networks and synapses. NRXN1α gene mutations have been identified in neuropsychiatric diseases including Schizophrenia (SCZ) and Autism Spectrum Disorder (ASD). In order to get a better understanding of the pleiotropic behavioral manifestations caused by NRXN1α gene mutations, we performed a behavioral study of Nrxn1α heterozygous knock-out (+/-) mice and observed increased responsiveness to novelty and accelerated habituation to novel environments compared to wild type (+/+) litter-mates. However, this effect was mainly observed in male mice, strongly suggesting that gender-specific mechanisms play an important role in Nrxn1α-induced phenotypes.

Authors+Show Affiliations

Department of Neurosciences & Pharmacology, Division of Neuroscience, Rudolf Magnus Institute, University Medical Center Utrecht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22348092

Citation

Laarakker, Marijke C., et al. "Sex-dependent Novelty Response in Neurexin-1α Mutant Mice." PloS One, vol. 7, no. 2, 2012, pp. e31503.
Laarakker MC, Reinders NR, Bruining H, et al. Sex-dependent novelty response in neurexin-1α mutant mice. PLoS ONE. 2012;7(2):e31503.
Laarakker, M. C., Reinders, N. R., Bruining, H., Ophoff, R. A., & Kas, M. J. (2012). Sex-dependent novelty response in neurexin-1α mutant mice. PloS One, 7(2), e31503. https://doi.org/10.1371/journal.pone.0031503
Laarakker MC, et al. Sex-dependent Novelty Response in Neurexin-1α Mutant Mice. PLoS ONE. 2012;7(2):e31503. PubMed PMID: 22348092.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sex-dependent novelty response in neurexin-1α mutant mice. AU - Laarakker,Marijke C, AU - Reinders,Niels R, AU - Bruining,Hilgo, AU - Ophoff,Roel A, AU - Kas,Martien J H, Y1 - 2012/02/13/ PY - 2011/06/26/received PY - 2012/01/12/accepted PY - 2012/2/21/entrez PY - 2012/2/22/pubmed PY - 2012/8/1/medline SP - e31503 EP - e31503 JF - PloS one JO - PLoS ONE VL - 7 IS - 2 N2 - Neurexin-1 alpha (NRXN1α) belongs to the family of cell adhesion molecules (CAMs), which are involved in the formation of neuronal networks and synapses. NRXN1α gene mutations have been identified in neuropsychiatric diseases including Schizophrenia (SCZ) and Autism Spectrum Disorder (ASD). In order to get a better understanding of the pleiotropic behavioral manifestations caused by NRXN1α gene mutations, we performed a behavioral study of Nrxn1α heterozygous knock-out (+/-) mice and observed increased responsiveness to novelty and accelerated habituation to novel environments compared to wild type (+/+) litter-mates. However, this effect was mainly observed in male mice, strongly suggesting that gender-specific mechanisms play an important role in Nrxn1α-induced phenotypes. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/22348092/Sex_dependent_novelty_response_in_neurexin_1α_mutant_mice_ L2 - http://dx.plos.org/10.1371/journal.pone.0031503 DB - PRIME DP - Unbound Medicine ER -