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Chronic obstructive pulmonary disease: an independent risk factor for peptic ulcer bleeding: a nationwide population-based study.
Aliment Pharmacol Ther 2012; 35(7):796-802AP

Abstract

BACKGROUND

Peptic ulcer bleeding remains a major healthcare problem despite decreasing prevalence of peptic ulcer disease. The role of chronic obstructive pulmonary disease (COPD) in the risk of peptic ulcer bleeding has not yet been established.

AIM

To determine if COPD patients have a higher risk of peptic ulcer bleeding than the general population and to identify the risk factors of peptic ulcer bleeding in COPD patients.

METHODS

From Taiwan's National Health Insurance research database, 62,876 patients, including 32,682 COPD and 30,194 age-gender-matched non-COPD controls, were recruited. Cox proportional hazard regression was performed to evaluate independent risk factors for ulcer bleeding in all patients and to identify risk factors in COPD patients.

RESULTS

During the 8-year follow-up, COPD patients had a significant higher rate of peptic ulcer bleeding than the control group (P < 0.001, by log-rank test). By Cox proportional hazard regression analysis, COPD [hazard ratio (HR) 1.93, 95% CI 1.73-2.17] was an independent risk factor after adjusting for age, gender, underlying comorbidities and ulcerogenic medication. Age > 65 years, male, comorbidities of hypertension, diabetes, heart failure, history of peptic ulcer disease, and chronic renal disease and use of nonsteroidal anti-inflammatory drugs were risk factors of ulcer bleeding in COPD patients.

CONCLUSION

Patients with chronic obstructive pulmonary disease have a higher risk of peptic ulcer bleeding after adjustments for possible confounding factors like underlying comorbidities and ulcerogenic medication.

Authors+Show Affiliations

Department of Medicine, National Yang-Ming University, School of Medicine, Taipei, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22348540

Citation

Huang, K-W, et al. "Chronic Obstructive Pulmonary Disease: an Independent Risk Factor for Peptic Ulcer Bleeding: a Nationwide Population-based Study." Alimentary Pharmacology & Therapeutics, vol. 35, no. 7, 2012, pp. 796-802.
Huang KW, Luo JC, Leu HB, et al. Chronic obstructive pulmonary disease: an independent risk factor for peptic ulcer bleeding: a nationwide population-based study. Aliment Pharmacol Ther. 2012;35(7):796-802.
Huang, K. W., Luo, J. C., Leu, H. B., Lin, H. C., Lee, F. Y., Chan, W. L., ... Chang, F. Y. (2012). Chronic obstructive pulmonary disease: an independent risk factor for peptic ulcer bleeding: a nationwide population-based study. Alimentary Pharmacology & Therapeutics, 35(7), pp. 796-802. doi:10.1111/j.1365-2036.2012.05028.x.
Huang KW, et al. Chronic Obstructive Pulmonary Disease: an Independent Risk Factor for Peptic Ulcer Bleeding: a Nationwide Population-based Study. Aliment Pharmacol Ther. 2012;35(7):796-802. PubMed PMID: 22348540.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic obstructive pulmonary disease: an independent risk factor for peptic ulcer bleeding: a nationwide population-based study. AU - Huang,K-W, AU - Luo,J-C, AU - Leu,H-B, AU - Lin,H-C, AU - Lee,F-Y, AU - Chan,W-L, AU - Lin,S-J, AU - Chen,J-W, AU - Chang,F-Y, Y1 - 2012/02/21/ PY - 2012/01/11/received PY - 2012/01/18/revised PY - 2012/01/26/revised PY - 2012/01/26/accepted PY - 2012/2/22/entrez PY - 2012/2/22/pubmed PY - 2012/6/1/medline SP - 796 EP - 802 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 35 IS - 7 N2 - BACKGROUND: Peptic ulcer bleeding remains a major healthcare problem despite decreasing prevalence of peptic ulcer disease. The role of chronic obstructive pulmonary disease (COPD) in the risk of peptic ulcer bleeding has not yet been established. AIM: To determine if COPD patients have a higher risk of peptic ulcer bleeding than the general population and to identify the risk factors of peptic ulcer bleeding in COPD patients. METHODS: From Taiwan's National Health Insurance research database, 62,876 patients, including 32,682 COPD and 30,194 age-gender-matched non-COPD controls, were recruited. Cox proportional hazard regression was performed to evaluate independent risk factors for ulcer bleeding in all patients and to identify risk factors in COPD patients. RESULTS: During the 8-year follow-up, COPD patients had a significant higher rate of peptic ulcer bleeding than the control group (P < 0.001, by log-rank test). By Cox proportional hazard regression analysis, COPD [hazard ratio (HR) 1.93, 95% CI 1.73-2.17] was an independent risk factor after adjusting for age, gender, underlying comorbidities and ulcerogenic medication. Age > 65 years, male, comorbidities of hypertension, diabetes, heart failure, history of peptic ulcer disease, and chronic renal disease and use of nonsteroidal anti-inflammatory drugs were risk factors of ulcer bleeding in COPD patients. CONCLUSION: Patients with chronic obstructive pulmonary disease have a higher risk of peptic ulcer bleeding after adjustments for possible confounding factors like underlying comorbidities and ulcerogenic medication. SN - 1365-2036 UR - https://www.unboundmedicine.com/medline/citation/22348540/Chronic_obstructive_pulmonary_disease:_an_independent_risk_factor_for_peptic_ulcer_bleeding:_a_nationwide_population_based_study_ L2 - https://doi.org/10.1111/j.1365-2036.2012.05028.x DB - PRIME DP - Unbound Medicine ER -