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Interaction between zinc, cadmium, and lead in scalp hair samples of Pakistani and Irish smokers rheumatoid arthritis subjects in relation to controls.
Biol Trace Elem Res 2012; 148(2):139-47BT

Abstract

The incidence of rheumatoid arthritis (RA) has been associated with cigarette smoking. The aim of our study was to assess the trace essential and toxic metals, cadmium (Cd), lead (Pb), and zinc (Zn), in scalp hair samples of 32 Irish and 46 Pakistani smokers and non-smokers RA male patients with age range 42-56 years. For comparison purpose, the scalp hair samples of 27 Irish and 55 Pakistani non-RA male subjects of the same age group were collected. The concentrations of trace and toxic elements were measured by inductive coupled plasma atomic emission spectrophotometer and atomic absorption spectrophotometer prior to microwave-assisted acid digestion. The validity and accuracy of the methodology was checked using certified reference materials and using conventional wet acid digestion method on the same certified reference materials (CRMs). The recovery of all studied elements was found to be in the range of 97.5-99.7% of certified reference values of CRMs. The results of this study showed that the mean values of Cd and Pb were significantly higher in scalp hair samples of both smoker and non-smoker RA patients than in referents (P < 0.001), whereas the concentration of Zn was lower in the scalp hair samples of smokers and non-smokers rheumatoid arthritis patients. The deficiency of Zn and the high exposure of Cd and Pb as a result of cigarette smoking may be synergistic risk factors associated with rheumatoid arthritis.

Authors+Show Affiliations

Mechanical & Manufacturing Engineering, Dublin City University, Dublin, Ireland. hassanimranafridi@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22351104

Citation

Afridi, Hassan Imran, et al. "Interaction Between Zinc, Cadmium, and Lead in Scalp Hair Samples of Pakistani and Irish Smokers Rheumatoid Arthritis Subjects in Relation to Controls." Biological Trace Element Research, vol. 148, no. 2, 2012, pp. 139-47.
Afridi HI, Kazi TG, Brabazon D, et al. Interaction between zinc, cadmium, and lead in scalp hair samples of Pakistani and Irish smokers rheumatoid arthritis subjects in relation to controls. Biol Trace Elem Res. 2012;148(2):139-47.
Afridi, H. I., Kazi, T. G., Brabazon, D., & Naher, S. (2012). Interaction between zinc, cadmium, and lead in scalp hair samples of Pakistani and Irish smokers rheumatoid arthritis subjects in relation to controls. Biological Trace Element Research, 148(2), pp. 139-47. doi:10.1007/s12011-012-9352-6.
Afridi HI, et al. Interaction Between Zinc, Cadmium, and Lead in Scalp Hair Samples of Pakistani and Irish Smokers Rheumatoid Arthritis Subjects in Relation to Controls. Biol Trace Elem Res. 2012;148(2):139-47. PubMed PMID: 22351104.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction between zinc, cadmium, and lead in scalp hair samples of Pakistani and Irish smokers rheumatoid arthritis subjects in relation to controls. AU - Afridi,Hassan Imran, AU - Kazi,Tasneem Gul, AU - Brabazon,Dermot, AU - Naher,Sumsun, Y1 - 2012/02/15/ PY - 2011/11/13/received PY - 2012/01/27/accepted PY - 2012/2/22/entrez PY - 2012/2/22/pubmed PY - 2013/1/1/medline SP - 139 EP - 47 JF - Biological trace element research JO - Biol Trace Elem Res VL - 148 IS - 2 N2 - The incidence of rheumatoid arthritis (RA) has been associated with cigarette smoking. The aim of our study was to assess the trace essential and toxic metals, cadmium (Cd), lead (Pb), and zinc (Zn), in scalp hair samples of 32 Irish and 46 Pakistani smokers and non-smokers RA male patients with age range 42-56 years. For comparison purpose, the scalp hair samples of 27 Irish and 55 Pakistani non-RA male subjects of the same age group were collected. The concentrations of trace and toxic elements were measured by inductive coupled plasma atomic emission spectrophotometer and atomic absorption spectrophotometer prior to microwave-assisted acid digestion. The validity and accuracy of the methodology was checked using certified reference materials and using conventional wet acid digestion method on the same certified reference materials (CRMs). The recovery of all studied elements was found to be in the range of 97.5-99.7% of certified reference values of CRMs. The results of this study showed that the mean values of Cd and Pb were significantly higher in scalp hair samples of both smoker and non-smoker RA patients than in referents (P < 0.001), whereas the concentration of Zn was lower in the scalp hair samples of smokers and non-smokers rheumatoid arthritis patients. The deficiency of Zn and the high exposure of Cd and Pb as a result of cigarette smoking may be synergistic risk factors associated with rheumatoid arthritis. SN - 1559-0720 UR - https://www.unboundmedicine.com/medline/citation/22351104/Interaction_between_zinc_cadmium_and_lead_in_scalp_hair_samples_of_Pakistani_and_Irish_smokers_rheumatoid_arthritis_subjects_in_relation_to_controls_ L2 - https://dx.doi.org/10.1007/s12011-012-9352-6 DB - PRIME DP - Unbound Medicine ER -