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Therapeutic effects of ivabradine on hemodynamic parameters and cardiotoxicity induced by doxorubicin treatment in rat.
Hum Exp Toxicol. 2012 Sep; 31(9):945-54.HE

Abstract

The aim of this study was to investigate the possible effects of ivabradine against doxorubicin (DOX)-induced cardiotoxicity in rats using hemodynamic parameters (electrocardiogram, heart rate (HR), and blood pressure), biochemical markers of oxidative stress, lactate dehydrogenase, aspartate transaminase, creatine kinase-MB, and histopathological analyses both in serum and tissue specimens. A total of 28 female rats were randomly assigned to 4 groups: (a) control (n = 6 rats), (b) DOX group (n = 7 rats), (c) DOX + ivabradine-treated group (n = 8 rats), and (d) ivabradine group (n = 7 rats). When the means of the four groups were compared, there was only a significant difference in the level of HR (p < 0.05). DOX treatment caused more HR elevation when compared to the control group, whereas ivabradine application after DOX treatment significantly reduced HR levels. Cardiomyocytes were revealed as normal histology in the light of both hematoxylin and eosin staining and immunostaining methods (caspase-3 and bcl-2) in all groups. The present study reported the therapeutic effects of ivabradine against DOX-induced cardiotoxicity accompanied by the hemodynamic and biochemical parameters.

Authors+Show Affiliations

Department of Cardiovascular Surgery, Inonu University, Malatya, Turkey. drmccolak@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22354086

Citation

Colak, M C., et al. "Therapeutic Effects of Ivabradine On Hemodynamic Parameters and Cardiotoxicity Induced By Doxorubicin Treatment in Rat." Human & Experimental Toxicology, vol. 31, no. 9, 2012, pp. 945-54.
Colak MC, Parlakpinar H, Tasdemir S, et al. Therapeutic effects of ivabradine on hemodynamic parameters and cardiotoxicity induced by doxorubicin treatment in rat. Hum Exp Toxicol. 2012;31(9):945-54.
Colak, M. C., Parlakpinar, H., Tasdemir, S., Samdanci, E., Kose, E., Polat, A., Sarihan, E., & Acet, A. (2012). Therapeutic effects of ivabradine on hemodynamic parameters and cardiotoxicity induced by doxorubicin treatment in rat. Human & Experimental Toxicology, 31(9), 945-54.
Colak MC, et al. Therapeutic Effects of Ivabradine On Hemodynamic Parameters and Cardiotoxicity Induced By Doxorubicin Treatment in Rat. Hum Exp Toxicol. 2012;31(9):945-54. PubMed PMID: 22354086.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Therapeutic effects of ivabradine on hemodynamic parameters and cardiotoxicity induced by doxorubicin treatment in rat. AU - Colak,M C, AU - Parlakpinar,H, AU - Tasdemir,S, AU - Samdanci,E, AU - Kose,E, AU - Polat,A, AU - Sarihan,E, AU - Acet,A, Y1 - 2012/02/21/ PY - 2012/2/23/entrez PY - 2012/2/23/pubmed PY - 2013/2/6/medline SP - 945 EP - 54 JF - Human & experimental toxicology JO - Hum Exp Toxicol VL - 31 IS - 9 N2 - The aim of this study was to investigate the possible effects of ivabradine against doxorubicin (DOX)-induced cardiotoxicity in rats using hemodynamic parameters (electrocardiogram, heart rate (HR), and blood pressure), biochemical markers of oxidative stress, lactate dehydrogenase, aspartate transaminase, creatine kinase-MB, and histopathological analyses both in serum and tissue specimens. A total of 28 female rats were randomly assigned to 4 groups: (a) control (n = 6 rats), (b) DOX group (n = 7 rats), (c) DOX + ivabradine-treated group (n = 8 rats), and (d) ivabradine group (n = 7 rats). When the means of the four groups were compared, there was only a significant difference in the level of HR (p < 0.05). DOX treatment caused more HR elevation when compared to the control group, whereas ivabradine application after DOX treatment significantly reduced HR levels. Cardiomyocytes were revealed as normal histology in the light of both hematoxylin and eosin staining and immunostaining methods (caspase-3 and bcl-2) in all groups. The present study reported the therapeutic effects of ivabradine against DOX-induced cardiotoxicity accompanied by the hemodynamic and biochemical parameters. SN - 1477-0903 UR - https://www.unboundmedicine.com/medline/citation/22354086/Therapeutic_effects_of_ivabradine_on_hemodynamic_parameters_and_cardiotoxicity_induced_by_doxorubicin_treatment_in_rat_ L2 - http://journals.sagepub.com/doi/full/10.1177/0960327112438288?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -