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Influence of inhaled beclomethasone and montelukast on airway remodeling in mice.
Inflammopharmacology. 2013 Feb; 21(1):55-66.I

Abstract

This study examined the effect of montelukast and beclomethasone on airway remodeling in murine model of asthma. Mice were sensitized by i.p. injection of ovalbumin (OVA) on days 0 and 14, and then challenged by nebulization of 1% OVA 3 days/week for 6 or 10 weeks. Results of 6-week OVA-challenged group showed moderate inflammation, but the 10-week OVA-challenged group exhibited mild inflammation. The OVA challenge (6 and 10 weeks) exhibited marked airway fibrosis, illustrated by significant increase in goblet cell hyperplasia and epithelial thickness, increased lung content of collagen and transforming growth factor-β(1), together with a decrease in nitric oxide production; also, there was an increase in bronchoalveolar lavage fluid level of interleukin-13. Administration of montelukast or beclomethasone before each OVA challenge was capable of restoring most of the measured parameters to near normal levels. Inhalation of beclomethasone has a similar role in airway remodeling as montelukast, but its effects in regulating inflammatory changes is less pronounced than montelukast.

Authors+Show Affiliations

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. rania200582@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

22354687

Citation

Abdel Aziz, Rania R., et al. "Influence of Inhaled Beclomethasone and Montelukast On Airway Remodeling in Mice." Inflammopharmacology, vol. 21, no. 1, 2013, pp. 55-66.
Abdel Aziz RR, Helaly NY, Zalata KR, et al. Influence of inhaled beclomethasone and montelukast on airway remodeling in mice. Inflammopharmacology. 2013;21(1):55-66.
Abdel Aziz, R. R., Helaly, N. Y., Zalata, K. R., & Gameil, N. M. (2013). Influence of inhaled beclomethasone and montelukast on airway remodeling in mice. Inflammopharmacology, 21(1), 55-66. https://doi.org/10.1007/s10787-012-0127-7
Abdel Aziz RR, et al. Influence of Inhaled Beclomethasone and Montelukast On Airway Remodeling in Mice. Inflammopharmacology. 2013;21(1):55-66. PubMed PMID: 22354687.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of inhaled beclomethasone and montelukast on airway remodeling in mice. AU - Abdel Aziz,Rania R, AU - Helaly,Nadia Y, AU - Zalata,Khaled R, AU - Gameil,Nariman M, Y1 - 2012/02/22/ PY - 2012/01/20/received PY - 2012/02/07/accepted PY - 2012/2/23/entrez PY - 2012/2/23/pubmed PY - 2013/7/23/medline SP - 55 EP - 66 JF - Inflammopharmacology JO - Inflammopharmacology VL - 21 IS - 1 N2 - This study examined the effect of montelukast and beclomethasone on airway remodeling in murine model of asthma. Mice were sensitized by i.p. injection of ovalbumin (OVA) on days 0 and 14, and then challenged by nebulization of 1% OVA 3 days/week for 6 or 10 weeks. Results of 6-week OVA-challenged group showed moderate inflammation, but the 10-week OVA-challenged group exhibited mild inflammation. The OVA challenge (6 and 10 weeks) exhibited marked airway fibrosis, illustrated by significant increase in goblet cell hyperplasia and epithelial thickness, increased lung content of collagen and transforming growth factor-β(1), together with a decrease in nitric oxide production; also, there was an increase in bronchoalveolar lavage fluid level of interleukin-13. Administration of montelukast or beclomethasone before each OVA challenge was capable of restoring most of the measured parameters to near normal levels. Inhalation of beclomethasone has a similar role in airway remodeling as montelukast, but its effects in regulating inflammatory changes is less pronounced than montelukast. SN - 1568-5608 UR - https://www.unboundmedicine.com/medline/citation/22354687/Influence_of_inhaled_beclomethasone_and_montelukast_on_airway_remodeling_in_mice_ L2 - https://medlineplus.gov/asthma.html DB - PRIME DP - Unbound Medicine ER -