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A water-soluble polycarbonate with dimethylamino pendant groups prepared by enzyme-catalyzed ring-opening polymerization.
Macromol Rapid Commun 2012; 33(8):693-7MR

Abstract

A water-soluble polycarbonate with dimethylamino pendant groups, poly(2-dimethylaminotrimethylene carbonate) (PDMATC), is synthesized and characterized. First, the six-membered carbonate monomer, 2-dimethylaminotrimethylene carbonate (DMATC), is prepared via the cyclization reaction of 2-(dimethylamino)propane-1,3-diol with triphosgene in the presence of triethylamine. Although the attempted ring-opening polymerization (ROP) of DMATC with Sn(Oct)(2) as a catalyst fails, the ROP of DMATC is successfully carried out with Novozym-435 as a catalyst to give water-soluble aliphatic polycarbonate PDMATC with low cytotoxicity and good degradability.

Authors+Show Affiliations

Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, PR China.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22354753

Citation

Zhang, Xiaojin, et al. "A Water-soluble Polycarbonate With Dimethylamino Pendant Groups Prepared By Enzyme-catalyzed Ring-opening Polymerization." Macromolecular Rapid Communications, vol. 33, no. 8, 2012, pp. 693-7.
Zhang X, Cai M, Zhong Z, et al. A water-soluble polycarbonate with dimethylamino pendant groups prepared by enzyme-catalyzed ring-opening polymerization. Macromol Rapid Commun. 2012;33(8):693-7.
Zhang, X., Cai, M., Zhong, Z., & Zhuo, R. (2012). A water-soluble polycarbonate with dimethylamino pendant groups prepared by enzyme-catalyzed ring-opening polymerization. Macromolecular Rapid Communications, 33(8), pp. 693-7. doi:10.1002/marc.201100765.
Zhang X, et al. A Water-soluble Polycarbonate With Dimethylamino Pendant Groups Prepared By Enzyme-catalyzed Ring-opening Polymerization. Macromol Rapid Commun. 2012 Apr 23;33(8):693-7. PubMed PMID: 22354753.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A water-soluble polycarbonate with dimethylamino pendant groups prepared by enzyme-catalyzed ring-opening polymerization. AU - Zhang,Xiaojin, AU - Cai,Mengmeng, AU - Zhong,Zhenlin, AU - Zhuo,Renxi, Y1 - 2012/02/21/ PY - 2011/11/14/received PY - 2011/12/09/revised PY - 2012/2/23/entrez PY - 2012/2/23/pubmed PY - 2012/8/11/medline SP - 693 EP - 7 JF - Macromolecular rapid communications JO - Macromol Rapid Commun VL - 33 IS - 8 N2 - A water-soluble polycarbonate with dimethylamino pendant groups, poly(2-dimethylaminotrimethylene carbonate) (PDMATC), is synthesized and characterized. First, the six-membered carbonate monomer, 2-dimethylaminotrimethylene carbonate (DMATC), is prepared via the cyclization reaction of 2-(dimethylamino)propane-1,3-diol with triphosgene in the presence of triethylamine. Although the attempted ring-opening polymerization (ROP) of DMATC with Sn(Oct)(2) as a catalyst fails, the ROP of DMATC is successfully carried out with Novozym-435 as a catalyst to give water-soluble aliphatic polycarbonate PDMATC with low cytotoxicity and good degradability. SN - 1521-3927 UR - https://www.unboundmedicine.com/medline/citation/22354753/A_water_soluble_polycarbonate_with_dimethylamino_pendant_groups_prepared_by_enzyme_catalyzed_ring_opening_polymerization_ L2 - https://doi.org/10.1002/marc.201100765 DB - PRIME DP - Unbound Medicine ER -