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Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells.
Sci Rep. 2011; 1:159.SR

Abstract

Aminoglycoside antibiotics rapidly enter and kill cochlear hair cells via apical mechanoelectrical transduction (MET) channels in vitro. In vivo, it remains unknown whether systemically-administered aminoglycosides cross the blood-labyrinth barrier into endolymph and enter hair cells. Here we show, for the first time, that systemic aminoglycosides are trafficked across the blood-endolymph barrier and preferentially enter hair cells across their apical membranes. This trafficking route is predominant compared to uptake via hair cell basolateral membranes during perilymph infusion.

Authors+Show Affiliations

Oregon Hearing Research Center, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22355674

Citation

Li, Hongzhe, and Peter S. Steyger. "Systemic Aminoglycosides Are Trafficked Via Endolymph Into Cochlear Hair Cells." Scientific Reports, vol. 1, 2011, p. 159.
Li H, Steyger PS. Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells. Sci Rep. 2011;1:159.
Li, H., & Steyger, P. S. (2011). Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells. Scientific Reports, 1, 159. https://doi.org/10.1038/srep00159
Li H, Steyger PS. Systemic Aminoglycosides Are Trafficked Via Endolymph Into Cochlear Hair Cells. Sci Rep. 2011;1:159. PubMed PMID: 22355674.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Systemic aminoglycosides are trafficked via endolymph into cochlear hair cells. AU - Li,Hongzhe, AU - Steyger,Peter S, Y1 - 2011/11/16/ PY - 2011/07/18/received PY - 2011/10/31/accepted PY - 2012/2/23/entrez PY - 2012/2/23/pubmed PY - 2012/2/23/medline SP - 159 EP - 159 JF - Scientific reports JO - Sci Rep VL - 1 N2 - Aminoglycoside antibiotics rapidly enter and kill cochlear hair cells via apical mechanoelectrical transduction (MET) channels in vitro. In vivo, it remains unknown whether systemically-administered aminoglycosides cross the blood-labyrinth barrier into endolymph and enter hair cells. Here we show, for the first time, that systemic aminoglycosides are trafficked across the blood-endolymph barrier and preferentially enter hair cells across their apical membranes. This trafficking route is predominant compared to uptake via hair cell basolateral membranes during perilymph infusion. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/22355674/Systemic_aminoglycosides_are_trafficked_via_endolymph_into_cochlear_hair_cells_ L2 - http://dx.doi.org/10.1038/srep00159 DB - PRIME DP - Unbound Medicine ER -