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Diurnal patterns of salivary cortisol and DHEA in adolescent anorexia nervosa.
Stress. 2012 Nov; 15(6):601-7.S

Abstract

Although there is well-documented evidence for hyperactivity of hypothalamic-pituitary-adrenal (HPA) axis function in anorexia nervosa (AN), there has been little research into secretory patterns of salivary cortisol and dehydroepiandrosterone (DHEA) in this condition. The cortisol awakening response (CAR), a prominent and discrete feature of the cortisol cycle, has not been extensively explored in adolescent AN. Saliva samples were collected at awakening, 30 min and 12 h post-awakening on two consecutive weekdays from eight female adolescents with clinically diagnosed AN and 41 healthy control (HC) age-matched females. Adolescent AN patients had greater salivary cortisol and DHEA concentrations than HC girls at all points. Increased hormone secretion was unrelated to body mass index. However, despite hypersecretion of both hormones, the circadian pattern including the CAR paralleled that of the HC group. Findings from this preliminary study confirm dysregulation of HPA axis function in adolescent AN as evidenced by hypersecretion of both cortisol and DHEA, which share the common secretagogue adrenocorticotropic hormone. However, the parallel diurnal profiles for AN and HC participants, including the CAR, may indicate hypersecretion per se rather than differential regulation of the diurnal pattern of these two adrenal steroids in AN.

Authors+Show Affiliations

Department of Psychology, University of Westminster, 309 Regent Street, London, W1B 2UW, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22356124

Citation

Oskis, Andrea, et al. "Diurnal Patterns of Salivary Cortisol and DHEA in Adolescent Anorexia Nervosa." Stress (Amsterdam, Netherlands), vol. 15, no. 6, 2012, pp. 601-7.
Oskis A, Loveday C, Hucklebridge F, et al. Diurnal patterns of salivary cortisol and DHEA in adolescent anorexia nervosa. Stress. 2012;15(6):601-7.
Oskis, A., Loveday, C., Hucklebridge, F., Thorn, L., & Clow, A. (2012). Diurnal patterns of salivary cortisol and DHEA in adolescent anorexia nervosa. Stress (Amsterdam, Netherlands), 15(6), 601-7. https://doi.org/10.3109/10253890.2012.661493
Oskis A, et al. Diurnal Patterns of Salivary Cortisol and DHEA in Adolescent Anorexia Nervosa. Stress. 2012;15(6):601-7. PubMed PMID: 22356124.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diurnal patterns of salivary cortisol and DHEA in adolescent anorexia nervosa. AU - Oskis,Andrea, AU - Loveday,Catherine, AU - Hucklebridge,Frank, AU - Thorn,Lisa, AU - Clow,Angela, Y1 - 2012/02/29/ PY - 2012/2/24/entrez PY - 2012/2/24/pubmed PY - 2013/3/9/medline SP - 601 EP - 7 JF - Stress (Amsterdam, Netherlands) JO - Stress VL - 15 IS - 6 N2 - Although there is well-documented evidence for hyperactivity of hypothalamic-pituitary-adrenal (HPA) axis function in anorexia nervosa (AN), there has been little research into secretory patterns of salivary cortisol and dehydroepiandrosterone (DHEA) in this condition. The cortisol awakening response (CAR), a prominent and discrete feature of the cortisol cycle, has not been extensively explored in adolescent AN. Saliva samples were collected at awakening, 30 min and 12 h post-awakening on two consecutive weekdays from eight female adolescents with clinically diagnosed AN and 41 healthy control (HC) age-matched females. Adolescent AN patients had greater salivary cortisol and DHEA concentrations than HC girls at all points. Increased hormone secretion was unrelated to body mass index. However, despite hypersecretion of both hormones, the circadian pattern including the CAR paralleled that of the HC group. Findings from this preliminary study confirm dysregulation of HPA axis function in adolescent AN as evidenced by hypersecretion of both cortisol and DHEA, which share the common secretagogue adrenocorticotropic hormone. However, the parallel diurnal profiles for AN and HC participants, including the CAR, may indicate hypersecretion per se rather than differential regulation of the diurnal pattern of these two adrenal steroids in AN. SN - 1607-8888 UR - https://www.unboundmedicine.com/medline/citation/22356124/Diurnal_patterns_of_salivary_cortisol_and_DHEA_in_adolescent_anorexia_nervosa_ L2 - https://www.tandfonline.com/doi/full/10.3109/10253890.2012.661493 DB - PRIME DP - Unbound Medicine ER -