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Benefits of combinations of vitamin A, C and E derivatives in the stability of cosmetic formulations.
Molecules. 2012 Feb 22; 17(2):2219-30.M

Abstract

Chemically stable ester derivatives of vitamins A, C and E have become a focus of interest for their role in the satisfactory results in skin aging treatments. Accordingly, the aim of this study was to evaluate the physical and chemical stability of a cosmetic formulation containing 1% retinyl palmitate, ascorbyl tetraisopalmitate and tocopheryl acetate, alone or in combination. In the studies of physical stability, a Brookfield rheometer was used to determine rheological behavior of formulations containing the vitamins. Chemical stability was determined by HPLC on a Shimadzu system with UV detection. Results showed that formulations had pseudoplastic behavior and that vitamins did not alter their apparent viscosity and thixotropy. In the chemical stability studies, first-order reaction equations were used for determinations of the shelf-life of vitamins derivatives considering a remaining concentration of 85%. Combined vitamins in a single formulation had a slightly lower degradation rate as compared to different preparations containing only one of the vitamins. Considering that many cosmetic formulations contain vitamin combinations it is suggested that the present study may contribute to the development of more stable formulations containing liposoluble vitamins.

Authors+Show Affiliations

Faculty of Pharmaceutical Sciences of Ribeirao Preto, University of Sao Paulo, Av do Cafe s/n, Monte Alegre, Ribeirao Preto 14040-903, SP, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22357318

Citation

Gianeti, Mirela Donato, et al. "Benefits of Combinations of Vitamin A, C and E Derivatives in the Stability of Cosmetic Formulations." Molecules (Basel, Switzerland), vol. 17, no. 2, 2012, pp. 2219-30.
Gianeti MD, Gaspar LR, Camargo FB, et al. Benefits of combinations of vitamin A, C and E derivatives in the stability of cosmetic formulations. Molecules. 2012;17(2):2219-30.
Gianeti, M. D., Gaspar, L. R., Camargo, F. B., & Campos, P. M. (2012). Benefits of combinations of vitamin A, C and E derivatives in the stability of cosmetic formulations. Molecules (Basel, Switzerland), 17(2), 2219-30. https://doi.org/10.3390/molecules17022219
Gianeti MD, et al. Benefits of Combinations of Vitamin A, C and E Derivatives in the Stability of Cosmetic Formulations. Molecules. 2012 Feb 22;17(2):2219-30. PubMed PMID: 22357318.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Benefits of combinations of vitamin A, C and E derivatives in the stability of cosmetic formulations. AU - Gianeti,Mirela Donato, AU - Gaspar,Lorena Rigo, AU - Camargo,Flávio Bueno de,Jr AU - Campos,Patrícia Maria Berardo Gonçalves Maia, Y1 - 2012/02/22/ PY - 2011/12/19/received PY - 2012/02/01/revised PY - 2012/02/16/accepted PY - 2012/2/24/entrez PY - 2012/2/24/pubmed PY - 2012/10/10/medline SP - 2219 EP - 30 JF - Molecules (Basel, Switzerland) JO - Molecules VL - 17 IS - 2 N2 - Chemically stable ester derivatives of vitamins A, C and E have become a focus of interest for their role in the satisfactory results in skin aging treatments. Accordingly, the aim of this study was to evaluate the physical and chemical stability of a cosmetic formulation containing 1% retinyl palmitate, ascorbyl tetraisopalmitate and tocopheryl acetate, alone or in combination. In the studies of physical stability, a Brookfield rheometer was used to determine rheological behavior of formulations containing the vitamins. Chemical stability was determined by HPLC on a Shimadzu system with UV detection. Results showed that formulations had pseudoplastic behavior and that vitamins did not alter their apparent viscosity and thixotropy. In the chemical stability studies, first-order reaction equations were used for determinations of the shelf-life of vitamins derivatives considering a remaining concentration of 85%. Combined vitamins in a single formulation had a slightly lower degradation rate as compared to different preparations containing only one of the vitamins. Considering that many cosmetic formulations contain vitamin combinations it is suggested that the present study may contribute to the development of more stable formulations containing liposoluble vitamins. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/22357318/Benefits_of_combinations_of_vitamin_A_C_and_E_derivatives_in_the_stability_of_cosmetic_formulations_ L2 - http://www.mdpi.com/resolver?pii=molecules17022219 DB - PRIME DP - Unbound Medicine ER -