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Alcohol drinking and non-Hodgkin lymphoma risk: a systematic review and a meta-analysis.
Ann Oncol 2012; 23(11):2791-8AO

Abstract

BACKGROUND

Whether an association between alcohol drinking and non-Hodgkin lymphoma (NHL) risk exists is an open question. In order to provide quantification of the issue, we carried out a meta-analysis of published data.

METHODS

We identified 21 case-control and 8 cohort studies, including a total of 18,759 NHL cases. We derived meta-analytic estimates using random-effects models, taking into account correlation between estimates.

RESULTS

The overall relative risk (RR) of NHL for drinkers versus non-drinkers was 0.85 [95% confidence interval (CI) 0.79-0.91]. Compared with non-drinkers, the pooled RRs were 0.88 for light (≤1 drink per day), 0.87 for moderate (1 to <4 drinks per day), and 0.84 for heavy (≥4 drinks per day) alcohol drinking. There was no association for light drinkers in cohort studies, whereas for moderate and heavy drinkers, the RRs were similar in case-control (0.85 for moderate, 0.92 for heavy) and cohort (0.89 for moderate, 0.79 for heavy) studies. The inverse relation with alcohol consumption (drinkers versus non-drinkers) was similar in men (RR = 0.83) and women (RR = 0.86), but apparently stronger in studies from Asia (RR = 0.69) than other world areas (RR = 0.88).

CONCLUSION

This meta-analysis provides quantitative evidence of a favourable role of alcohol drinking on NHL risk, though the lack of a biological explanation suggests caution in the interpretation of results.

Authors+Show Affiliations

Department of Epidemiology, Mario Negri Institute for Pharmacological Research, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

22357444

Citation

Tramacere, I, et al. "Alcohol Drinking and non-Hodgkin Lymphoma Risk: a Systematic Review and a Meta-analysis." Annals of Oncology : Official Journal of the European Society for Medical Oncology, vol. 23, no. 11, 2012, pp. 2791-8.
Tramacere I, Pelucchi C, Bonifazi M, et al. Alcohol drinking and non-Hodgkin lymphoma risk: a systematic review and a meta-analysis. Ann Oncol. 2012;23(11):2791-8.
Tramacere, I., Pelucchi, C., Bonifazi, M., Bagnardi, V., Rota, M., Bellocco, R., ... Negri, E. (2012). Alcohol drinking and non-Hodgkin lymphoma risk: a systematic review and a meta-analysis. Annals of Oncology : Official Journal of the European Society for Medical Oncology, 23(11), pp. 2791-8. doi:10.1093/annonc/mds013.
Tramacere I, et al. Alcohol Drinking and non-Hodgkin Lymphoma Risk: a Systematic Review and a Meta-analysis. Ann Oncol. 2012;23(11):2791-8. PubMed PMID: 22357444.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol drinking and non-Hodgkin lymphoma risk: a systematic review and a meta-analysis. AU - Tramacere,I, AU - Pelucchi,C, AU - Bonifazi,M, AU - Bagnardi,V, AU - Rota,M, AU - Bellocco,R, AU - Scotti,L, AU - Islami,F, AU - Corrao,G, AU - Boffetta,P, AU - La Vecchia,C, AU - Negri,E, Y1 - 2012/02/22/ PY - 2012/2/24/entrez PY - 2012/2/24/pubmed PY - 2013/4/30/medline SP - 2791 EP - 8 JF - Annals of oncology : official journal of the European Society for Medical Oncology JO - Ann. Oncol. VL - 23 IS - 11 N2 - BACKGROUND: Whether an association between alcohol drinking and non-Hodgkin lymphoma (NHL) risk exists is an open question. In order to provide quantification of the issue, we carried out a meta-analysis of published data. METHODS: We identified 21 case-control and 8 cohort studies, including a total of 18,759 NHL cases. We derived meta-analytic estimates using random-effects models, taking into account correlation between estimates. RESULTS: The overall relative risk (RR) of NHL for drinkers versus non-drinkers was 0.85 [95% confidence interval (CI) 0.79-0.91]. Compared with non-drinkers, the pooled RRs were 0.88 for light (≤1 drink per day), 0.87 for moderate (1 to <4 drinks per day), and 0.84 for heavy (≥4 drinks per day) alcohol drinking. There was no association for light drinkers in cohort studies, whereas for moderate and heavy drinkers, the RRs were similar in case-control (0.85 for moderate, 0.92 for heavy) and cohort (0.89 for moderate, 0.79 for heavy) studies. The inverse relation with alcohol consumption (drinkers versus non-drinkers) was similar in men (RR = 0.83) and women (RR = 0.86), but apparently stronger in studies from Asia (RR = 0.69) than other world areas (RR = 0.88). CONCLUSION: This meta-analysis provides quantitative evidence of a favourable role of alcohol drinking on NHL risk, though the lack of a biological explanation suggests caution in the interpretation of results. SN - 1569-8041 UR - https://www.unboundmedicine.com/medline/citation/22357444/Alcohol_drinking_and_non_Hodgkin_lymphoma_risk:_a_systematic_review_and_a_meta_analysis_ L2 - https://academic.oup.com/annonc/article-lookup/doi/10.1093/annonc/mds013 DB - PRIME DP - Unbound Medicine ER -