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Age-related differences in patterns of increased Bordetella pertussis antibodies.
Clin Vaccine Immunol. 2012 Apr; 19(4):545-50.CV

Abstract

During the period 2008 to 2010, we identified 11,386 serum samples with increased (positive) levels of antibodies recognizing Bordetella pertussis antigens. We sought to characterize the distribution of positive antibody result patterns in relation to patient age. IgG and IgA antibodies recognizing pertussis toxin (PT) and filamentous hemagglutinin (FHA) were quantified using a multianalyte immunodetection assay. Four mutually exclusive positive result patterns were observed: increased FHA antibodies only, increased PT IgA but not IgG, increased PT IgG but not IgA, and increased PT IgG and IgA. In patients < 21 years old, the predominant pattern was increased PT IgG but not IgA, whereas in patients ≥ 21 years old, it was increased FHA antibodies only. The proportion of positive serum samples exhibiting increased PT IgA but not IgG was < 20% in all age categories but showed a stepwise rise with age. The proportions of positive serum samples exhibiting increased PT IgG and IgA were similar (26 to 32%) in the age categories spanning 11 to 60 years of age but lower in the < 11- and > 60-year-old groups. In 3 of 5 age categories, a significant rise in the proportion of positive serum samples exhibiting increased FHA antibodies only occurred in 2010. Patterns of positive B. pertussis antibody results varied with age. The predominance of increased FHA antibodies only in patients > 20 years old suggests that many adults thought to have B. pertussis infections actually have other infections that induce FHA-reactive antibodies. Similarly, the 2010 rise in the frequency of increased FHA antibodies only in some age groups suggests an increase in non-B. pertussis infections.

Authors+Show Affiliations

Focus Diagnostics, Inc., Cypress, California, USA. hprince@focusdx.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22357646

Citation

Prince, Harry E., et al. "Age-related Differences in Patterns of Increased Bordetella Pertussis Antibodies." Clinical and Vaccine Immunology : CVI, vol. 19, no. 4, 2012, pp. 545-50.
Prince HE, Lieberman JM, Cherry JD. Age-related differences in patterns of increased Bordetella pertussis antibodies. Clin Vaccine Immunol. 2012;19(4):545-50.
Prince, H. E., Lieberman, J. M., & Cherry, J. D. (2012). Age-related differences in patterns of increased Bordetella pertussis antibodies. Clinical and Vaccine Immunology : CVI, 19(4), 545-50. https://doi.org/10.1128/CVI.05725-11
Prince HE, Lieberman JM, Cherry JD. Age-related Differences in Patterns of Increased Bordetella Pertussis Antibodies. Clin Vaccine Immunol. 2012;19(4):545-50. PubMed PMID: 22357646.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age-related differences in patterns of increased Bordetella pertussis antibodies. AU - Prince,Harry E, AU - Lieberman,Jay M, AU - Cherry,James D, Y1 - 2012/02/22/ PY - 2012/2/24/entrez PY - 2012/2/24/pubmed PY - 2012/7/25/medline SP - 545 EP - 50 JF - Clinical and vaccine immunology : CVI JO - Clin Vaccine Immunol VL - 19 IS - 4 N2 - During the period 2008 to 2010, we identified 11,386 serum samples with increased (positive) levels of antibodies recognizing Bordetella pertussis antigens. We sought to characterize the distribution of positive antibody result patterns in relation to patient age. IgG and IgA antibodies recognizing pertussis toxin (PT) and filamentous hemagglutinin (FHA) were quantified using a multianalyte immunodetection assay. Four mutually exclusive positive result patterns were observed: increased FHA antibodies only, increased PT IgA but not IgG, increased PT IgG but not IgA, and increased PT IgG and IgA. In patients < 21 years old, the predominant pattern was increased PT IgG but not IgA, whereas in patients ≥ 21 years old, it was increased FHA antibodies only. The proportion of positive serum samples exhibiting increased PT IgA but not IgG was < 20% in all age categories but showed a stepwise rise with age. The proportions of positive serum samples exhibiting increased PT IgG and IgA were similar (26 to 32%) in the age categories spanning 11 to 60 years of age but lower in the < 11- and > 60-year-old groups. In 3 of 5 age categories, a significant rise in the proportion of positive serum samples exhibiting increased FHA antibodies only occurred in 2010. Patterns of positive B. pertussis antibody results varied with age. The predominance of increased FHA antibodies only in patients > 20 years old suggests that many adults thought to have B. pertussis infections actually have other infections that induce FHA-reactive antibodies. Similarly, the 2010 rise in the frequency of increased FHA antibodies only in some age groups suggests an increase in non-B. pertussis infections. SN - 1556-679X UR - https://www.unboundmedicine.com/medline/citation/22357646/Age_related_differences_in_patterns_of_increased_Bordetella_pertussis_antibodies_ L2 - https://journals.asm.org/doi/10.1128/CVI.05725-11?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -