Tags

Type your tag names separated by a space and hit enter

Urine risk factors in children with calcium kidney stones and their siblings.
Kidney Int. 2012 Jun; 81(11):1140-8.KI

Abstract

Calcium nephrolithiasis in children is increasing in prevalence and tends to be recurrent. Although children have a lower incidence of nephrolithiasis than adults, its etiology in children is less well understood; hence, treatments targeted for adults may not be optimal in children. To better understand metabolic abnormalities in stone-forming children, we compared chemical measurements and the crystallization properties of 24-h urine collections from 129 stone formers matched to 105 non-stone-forming siblings and 183 normal, healthy children with no family history of stones, all aged 6 to 17 years. The principal risk factor for calcium stone formation was hypercalciuria. Stone formers have strikingly higher calcium excretion along with high supersaturation for calcium oxalate and calcium phosphate, and a reduced distance between the upper limit of metastability and supersaturation for calcium phosphate, indicating increased risk of calcium phosphate crystallization. Other differences in urine chemistry that exist between adult stone formers and normal individuals such as hyperoxaluria, hypocitraturia, abnormal urine pH, and low urine volume were not found in these children. Hence, hypercalciuria and a reduction in the gap between calcium phosphate upper limit of metastability and supersaturation are crucial determinants of stone risk. This highlights the importance of managing hypercalciuria in children with calcium stones.

Authors+Show Affiliations

Nephrology Section, Department of Medicine, University of Chicago, Chicago, Illinois 60637, USA. kbergsland@uchicago.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

22358148

Citation

Bergsland, Kristin J., et al. "Urine Risk Factors in Children With Calcium Kidney Stones and Their Siblings." Kidney International, vol. 81, no. 11, 2012, pp. 1140-8.
Bergsland KJ, Coe FL, White MD, et al. Urine risk factors in children with calcium kidney stones and their siblings. Kidney Int. 2012;81(11):1140-8.
Bergsland, K. J., Coe, F. L., White, M. D., Erhard, M. J., DeFoor, W. R., Mahan, J. D., Schwaderer, A. L., & Asplin, J. R. (2012). Urine risk factors in children with calcium kidney stones and their siblings. Kidney International, 81(11), 1140-8. https://doi.org/10.1038/ki.2012.7
Bergsland KJ, et al. Urine Risk Factors in Children With Calcium Kidney Stones and Their Siblings. Kidney Int. 2012;81(11):1140-8. PubMed PMID: 22358148.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urine risk factors in children with calcium kidney stones and their siblings. AU - Bergsland,Kristin J, AU - Coe,Fredric L, AU - White,Mark D, AU - Erhard,Michael J, AU - DeFoor,William R, AU - Mahan,John D, AU - Schwaderer,Andrew L, AU - Asplin,John R, Y1 - 2012/02/22/ PY - 2012/2/24/entrez PY - 2012/2/24/pubmed PY - 2012/9/11/medline SP - 1140 EP - 8 JF - Kidney international JO - Kidney Int. VL - 81 IS - 11 N2 - Calcium nephrolithiasis in children is increasing in prevalence and tends to be recurrent. Although children have a lower incidence of nephrolithiasis than adults, its etiology in children is less well understood; hence, treatments targeted for adults may not be optimal in children. To better understand metabolic abnormalities in stone-forming children, we compared chemical measurements and the crystallization properties of 24-h urine collections from 129 stone formers matched to 105 non-stone-forming siblings and 183 normal, healthy children with no family history of stones, all aged 6 to 17 years. The principal risk factor for calcium stone formation was hypercalciuria. Stone formers have strikingly higher calcium excretion along with high supersaturation for calcium oxalate and calcium phosphate, and a reduced distance between the upper limit of metastability and supersaturation for calcium phosphate, indicating increased risk of calcium phosphate crystallization. Other differences in urine chemistry that exist between adult stone formers and normal individuals such as hyperoxaluria, hypocitraturia, abnormal urine pH, and low urine volume were not found in these children. Hence, hypercalciuria and a reduction in the gap between calcium phosphate upper limit of metastability and supersaturation are crucial determinants of stone risk. This highlights the importance of managing hypercalciuria in children with calcium stones. SN - 1523-1755 UR - https://www.unboundmedicine.com/medline/citation/22358148/Urine_risk_factors_in_children_with_calcium_kidney_stones_and_their_siblings_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0085-2538(15)55235-6 DB - PRIME DP - Unbound Medicine ER -