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Chronic Opium Treatment Can Differentially Induce Brain and Liver Cells Apoptosis in Diabetic and Non-diabetic Male and Female Rats.
Korean J Physiol Pharmacol. 2011 Dec; 15(6):327-32.KJ

Abstract

It has been shown that some opium derivatives promote cell death via apoptosis. This study was designed to examine the influence of opium addiction on brain and liver cells apoptosis in male and female diabetic and non-diabetic Wistar rats. This experimental study was performed on normal, opium-addicted, diabetic and diabetic opium-addicted male and female rats. Apoptosis was evaluated by TUNEL and DNA fragmentation assays. Results of this study showed that apoptosis in opium-addicted and diabetic opium-addicted brain and liver cells were significantly higher than the both normal and diabetic rats. In addition, we found that apoptosis in brain cells of opium-addicted and diabetic opium-addicted male rats were significantly higher than opium-addicted and diabetic opium-addicted female, whereas apoptosis in liver cells of opium-addicted and diabetic opium-addicted female rats were significantly higher than opium-addicted and diabetic opium-addicted male. Overall, these results indicate that opium probably plays an important role in brain and liver cells apoptosis, therefore, leading neurotoxicity and hepatotoxicity. These findings also in away possibly means that male brain cells are more susceptible than female and interestingly liver of females are more sensitive than males in induction of apoptosis by opium.

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Authors+Show Affiliations

Asiabanha M
Department of Biochemistry, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, P.O.Box: 7515412578, Iran.
Asadikaram G
No affiliation info available
Rahnema A
No affiliation info available
Mahmoodi M
No affiliation info available
Hasanshahi G
No affiliation info available
Hashemi M
No affiliation info available
Khaksari M
No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22359469

Citation

Asiabanha, Majid, et al. "Chronic Opium Treatment Can Differentially Induce Brain and Liver Cells Apoptosis in Diabetic and Non-diabetic Male and Female Rats." The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology, vol. 15, no. 6, 2011, pp. 327-32.
Asiabanha M, Asadikaram G, Rahnema A, et al. Chronic Opium Treatment Can Differentially Induce Brain and Liver Cells Apoptosis in Diabetic and Non-diabetic Male and Female Rats. Korean J Physiol Pharmacol. 2011;15(6):327-32.
Asiabanha, M., Asadikaram, G., Rahnema, A., Mahmoodi, M., Hasanshahi, G., Hashemi, M., & Khaksari, M. (2011). Chronic Opium Treatment Can Differentially Induce Brain and Liver Cells Apoptosis in Diabetic and Non-diabetic Male and Female Rats. The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology, 15(6), 327-32. https://doi.org/10.4196/kjpp.2011.15.6.327
Asiabanha M, et al. Chronic Opium Treatment Can Differentially Induce Brain and Liver Cells Apoptosis in Diabetic and Non-diabetic Male and Female Rats. Korean J Physiol Pharmacol. 2011;15(6):327-32. PubMed PMID: 22359469.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic Opium Treatment Can Differentially Induce Brain and Liver Cells Apoptosis in Diabetic and Non-diabetic Male and Female Rats. AU - Asiabanha,Majid, AU - Asadikaram,Gholamreza, AU - Rahnema,Amir, AU - Mahmoodi,Mehdi, AU - Hasanshahi,Gholamhosein, AU - Hashemi,Mohammad, AU - Khaksari,Mohammad, Y1 - 2011/12/27/ PY - 2011/06/07/received PY - 2011/10/12/revised PY - 2011/11/10/accepted PY - 2012/2/24/entrez PY - 2012/2/24/pubmed PY - 2012/2/24/medline KW - Addiction KW - Apoptosis KW - Brain cells KW - Diabetes KW - Liver cells SP - 327 EP - 32 JF - The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology JO - Korean J Physiol Pharmacol VL - 15 IS - 6 N2 - It has been shown that some opium derivatives promote cell death via apoptosis. This study was designed to examine the influence of opium addiction on brain and liver cells apoptosis in male and female diabetic and non-diabetic Wistar rats. This experimental study was performed on normal, opium-addicted, diabetic and diabetic opium-addicted male and female rats. Apoptosis was evaluated by TUNEL and DNA fragmentation assays. Results of this study showed that apoptosis in opium-addicted and diabetic opium-addicted brain and liver cells were significantly higher than the both normal and diabetic rats. In addition, we found that apoptosis in brain cells of opium-addicted and diabetic opium-addicted male rats were significantly higher than opium-addicted and diabetic opium-addicted female, whereas apoptosis in liver cells of opium-addicted and diabetic opium-addicted female rats were significantly higher than opium-addicted and diabetic opium-addicted male. Overall, these results indicate that opium probably plays an important role in brain and liver cells apoptosis, therefore, leading neurotoxicity and hepatotoxicity. These findings also in away possibly means that male brain cells are more susceptible than female and interestingly liver of females are more sensitive than males in induction of apoptosis by opium. SN - 2093-3827 UR - https://www.unboundmedicine.com/medline/citation/22359469/Chronic_Opium_Treatment_Can_Differentially_Induce_Brain_and_Liver_Cells_Apoptosis_in_Diabetic_and_Non_diabetic_Male_and_Female_Rats_ L2 - http://www.kjpp.net/journal/viewJournal.html?year=2011&vol=15&page=327 DB - PRIME DP - Unbound Medicine ER -