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Topically applied L-carnitine effectively reduces sebum secretion in human skin.
J Cosmet Dermatol 2012; 11(1):30-6JC

Abstract

BACKGROUND

Oily skin condition is caused by an excessive sebaceous gland activity, resulting in an overproduction of sebum, giving the skin an undesired shiny, oily appearance.

AIMS

To identify an active substance that reduces sebum production in human sebaceous glands by regulating fat metabolism in a natural way.

PATIENTS/METHODS

The effects of L-carnitine on β-oxidation and intracellular lipid content were investigated in vitro using the human sebaceous cell line SZ95. Penetration experiments utilizing pig skin as a model system were performed with a cosmetic formulation containing radioactively labeled L-carnitine. To determine the in vivo effects, a vehicle-controlled, randomized study was carried out using a cosmetic formulation containing 2%l-carnitine for 3 weeks. Sebum production was investigated utilizing the lipid-absorbent Sebutape(®).

RESULTS

SZ95 cells treated with 0.5% or 1% L-carnitine demonstrated a significant concentration-dependent increase in β-oxidation compared to control cells. Following the treatment with L-carnitine, intracellular lipid concentrations decreased significantly in a dose-dependent manner compared with untreated control cells. In skin penetration experiments, topically applied L-carnitine reached the dermis. In addition, topical in vivo application of a formulation containing 2% L-carnitine for 3 weeks significantly decreased the sebum secretion rate compared to the treatment with vehicle.

CONCLUSIONS

Our results show that the treatment of human sebocytes with L-carnitine significantly augments β-oxidation and significantly decreases intracellular lipid content in human sebocytes. Topically applied L-carnitine is bioavailable and leads to a significant sebum reduction in vivo. In conclusion, L-carnitine represents a valuable compound, produced naturally within the body, for the topical treatment of oily skin in humans.

Authors+Show Affiliations

Beiersdorf AG, Research & Development, Skin Research, Hamburg, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

22360332

Citation

Peirano, Reto I., et al. "Topically Applied L-carnitine Effectively Reduces Sebum Secretion in Human Skin." Journal of Cosmetic Dermatology, vol. 11, no. 1, 2012, pp. 30-6.
Peirano RI, Hamann T, Düsing HJ, et al. Topically applied L-carnitine effectively reduces sebum secretion in human skin. J Cosmet Dermatol. 2012;11(1):30-6.
Peirano, R. I., Hamann, T., Düsing, H. J., Akhiani, M., Koop, U., Schmidt-Rose, T., & Wenck, H. (2012). Topically applied L-carnitine effectively reduces sebum secretion in human skin. Journal of Cosmetic Dermatology, 11(1), pp. 30-6. doi:10.1111/j.1473-2165.2011.00597.x.
Peirano RI, et al. Topically Applied L-carnitine Effectively Reduces Sebum Secretion in Human Skin. J Cosmet Dermatol. 2012;11(1):30-6. PubMed PMID: 22360332.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Topically applied L-carnitine effectively reduces sebum secretion in human skin. AU - Peirano,Reto I, AU - Hamann,Tina, AU - Düsing,Hans-Jürgen, AU - Akhiani,Mehdi, AU - Koop,Urte, AU - Schmidt-Rose,Thomas, AU - Wenck,Horst, PY - 2012/2/25/entrez PY - 2012/3/1/pubmed PY - 2012/7/6/medline SP - 30 EP - 6 JF - Journal of cosmetic dermatology JO - J Cosmet Dermatol VL - 11 IS - 1 N2 - BACKGROUND: Oily skin condition is caused by an excessive sebaceous gland activity, resulting in an overproduction of sebum, giving the skin an undesired shiny, oily appearance. AIMS: To identify an active substance that reduces sebum production in human sebaceous glands by regulating fat metabolism in a natural way. PATIENTS/METHODS: The effects of L-carnitine on β-oxidation and intracellular lipid content were investigated in vitro using the human sebaceous cell line SZ95. Penetration experiments utilizing pig skin as a model system were performed with a cosmetic formulation containing radioactively labeled L-carnitine. To determine the in vivo effects, a vehicle-controlled, randomized study was carried out using a cosmetic formulation containing 2%l-carnitine for 3 weeks. Sebum production was investigated utilizing the lipid-absorbent Sebutape(®). RESULTS: SZ95 cells treated with 0.5% or 1% L-carnitine demonstrated a significant concentration-dependent increase in β-oxidation compared to control cells. Following the treatment with L-carnitine, intracellular lipid concentrations decreased significantly in a dose-dependent manner compared with untreated control cells. In skin penetration experiments, topically applied L-carnitine reached the dermis. In addition, topical in vivo application of a formulation containing 2% L-carnitine for 3 weeks significantly decreased the sebum secretion rate compared to the treatment with vehicle. CONCLUSIONS: Our results show that the treatment of human sebocytes with L-carnitine significantly augments β-oxidation and significantly decreases intracellular lipid content in human sebocytes. Topically applied L-carnitine is bioavailable and leads to a significant sebum reduction in vivo. In conclusion, L-carnitine represents a valuable compound, produced naturally within the body, for the topical treatment of oily skin in humans. SN - 1473-2165 UR - https://www.unboundmedicine.com/medline/citation/22360332/Topically_applied_L_carnitine_effectively_reduces_sebum_secretion_in_human_skin_ L2 - https://doi.org/10.1111/j.1473-2165.2011.00597.x DB - PRIME DP - Unbound Medicine ER -