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Estimating age-specific influenza-related hospitalization rates during the pandemic (H1N1) 2009 in Davidson Co, TN.
Influenza Other Respir Viruses 2012; 6(3):e63-71IO

Abstract

BACKGROUND

In April 2009, a pandemic caused by a novel influenza strain, the A(H1N1)pdm09 virus, started. Few age-specific estimates of hospitalizations associated with the first year of circulation of the pandemic virus are available.

OBJECTIVES

To estimate age-specific hospitalization rates associated with laboratory-confirmed A(H1N1)pdm09 virus in Davidson County, TN, from May 2009 to March 2010.

PATIENTS/METHODS

Two separate strategies were applied: capture-recapture and surveillance-sampling methods. For the capture-recapture estimates, we linked data collected via two independent prospective population-based surveillance systems: The Influenza Vaccine Effectiveness Network (Flu-VE) tested consenting county patients hospitalized with respiratory symptoms at selected hospitals using real-time reverse transcriptase polymerase chain reaction (rRT-PCR); the Emerging Infections Program identified county patients with positive influenza tests in all area hospitals. For the surveillance-sampling estimates, we applied the age-specific proportions of influenza-positive patients (from Flu-VE) to the number of acute respiratory illness hospitalizations obtained from the Tennessee Hospital Discharge Data system.

RESULTS

With capture-recapture, we estimated 0·89 (95% CI, 0·72-1·49), 0·62 (0·42-1·11), 1·78 (0·99-3·63), and 0·76 (0·50-1·76) hospitalizations per 1000 residents aged < 5, 5-17, 18-49, and ≥ 50 years, respectively. Surveillance-sampling estimated rates were 0·78 (0·46-1·22), 0·32 (0·14-0·69), 0·99 (0·64-1·52), and 1·43 (0·80-2·48) hospitalizations per 1000 residents aged <5, 5-17, 18-49, and ≥ 50 years, respectively. In all age-groups combined, we estimated approximately 1 influenza-related hospitalization per 1000 residents.

CONCLUSIONS

Two independent methods provided consistent results on the burden of pandemic virus in Davidson County and suggested that the overall incidence of A(H1N1)pdm09-associated hospitalization was 1 per 1000 county residents.

Authors+Show Affiliations

Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville, TN 37212, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

22360812

Citation

Jules, Astride, et al. "Estimating Age-specific Influenza-related Hospitalization Rates During the Pandemic (H1N1) 2009 in Davidson Co, TN." Influenza and Other Respiratory Viruses, vol. 6, no. 3, 2012, pp. e63-71.
Jules A, Grijalva CG, Zhu Y, et al. Estimating age-specific influenza-related hospitalization rates during the pandemic (H1N1) 2009 in Davidson Co, TN. Influenza Other Respir Viruses. 2012;6(3):e63-71.
Jules, A., Grijalva, C. G., Zhu, Y., Talbot, K. H., Williams, J. V., Dupont, W. D., ... Griffin, M. R. (2012). Estimating age-specific influenza-related hospitalization rates during the pandemic (H1N1) 2009 in Davidson Co, TN. Influenza and Other Respiratory Viruses, 6(3), pp. e63-71. doi:10.1111/j.1750-2659.2012.00343.x.
Jules A, et al. Estimating Age-specific Influenza-related Hospitalization Rates During the Pandemic (H1N1) 2009 in Davidson Co, TN. Influenza Other Respir Viruses. 2012;6(3):e63-71. PubMed PMID: 22360812.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Estimating age-specific influenza-related hospitalization rates during the pandemic (H1N1) 2009 in Davidson Co, TN. AU - Jules,Astride, AU - Grijalva,Carlos G, AU - Zhu,Yuwei, AU - Talbot,Keipp H, AU - Williams,John V, AU - Dupont,William D, AU - Edwards,Kathryn M, AU - Schaffner,William, AU - Shay,David K, AU - Griffin,Marie R, Y1 - 2012/02/23/ PY - 2012/2/25/entrez PY - 2012/3/1/pubmed PY - 2012/7/31/medline SP - e63 EP - 71 JF - Influenza and other respiratory viruses JO - Influenza Other Respir Viruses VL - 6 IS - 3 N2 - BACKGROUND: In April 2009, a pandemic caused by a novel influenza strain, the A(H1N1)pdm09 virus, started. Few age-specific estimates of hospitalizations associated with the first year of circulation of the pandemic virus are available. OBJECTIVES: To estimate age-specific hospitalization rates associated with laboratory-confirmed A(H1N1)pdm09 virus in Davidson County, TN, from May 2009 to March 2010. PATIENTS/METHODS: Two separate strategies were applied: capture-recapture and surveillance-sampling methods. For the capture-recapture estimates, we linked data collected via two independent prospective population-based surveillance systems: The Influenza Vaccine Effectiveness Network (Flu-VE) tested consenting county patients hospitalized with respiratory symptoms at selected hospitals using real-time reverse transcriptase polymerase chain reaction (rRT-PCR); the Emerging Infections Program identified county patients with positive influenza tests in all area hospitals. For the surveillance-sampling estimates, we applied the age-specific proportions of influenza-positive patients (from Flu-VE) to the number of acute respiratory illness hospitalizations obtained from the Tennessee Hospital Discharge Data system. RESULTS: With capture-recapture, we estimated 0·89 (95% CI, 0·72-1·49), 0·62 (0·42-1·11), 1·78 (0·99-3·63), and 0·76 (0·50-1·76) hospitalizations per 1000 residents aged < 5, 5-17, 18-49, and ≥ 50 years, respectively. Surveillance-sampling estimated rates were 0·78 (0·46-1·22), 0·32 (0·14-0·69), 0·99 (0·64-1·52), and 1·43 (0·80-2·48) hospitalizations per 1000 residents aged <5, 5-17, 18-49, and ≥ 50 years, respectively. In all age-groups combined, we estimated approximately 1 influenza-related hospitalization per 1000 residents. CONCLUSIONS: Two independent methods provided consistent results on the burden of pandemic virus in Davidson County and suggested that the overall incidence of A(H1N1)pdm09-associated hospitalization was 1 per 1000 county residents. SN - 1750-2659 UR - https://www.unboundmedicine.com/medline/citation/22360812/Estimating_age_specific_influenza_related_hospitalization_rates_during_the_pandemic__H1N1__2009_in_Davidson_Co_TN_ L2 - https://doi.org/10.1111/j.1750-2659.2012.00343.x DB - PRIME DP - Unbound Medicine ER -