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Factors associated with viral load suppression in HIV-infected pregnant women in Rio de Janeiro, Brazil.
Int J STD AIDS. 2012 Jan; 23(1):44-7.IJ

Abstract

Viral load (VL) near delivery is a determinant of mother-to-child transmission (MTCT) of HIV. To evaluate factors associated with an undetectable VL near delivery in HIV-infected pregnant women receiving highly active antiretroviral therapy (HAART) and non-HAART regimens, HIV-infected pregnant women with a detectable VL at entry and having used antiretrovirals for ≥4 weeks before delivery were selected. Multivariate analysis was employed using binary logistic unconditional models; the dependent variable was having a VL <400 copies/mL near delivery. VL suppression was achieved in 403/707 women (57%): 65.4% in the HAART group, but only 26% in the non-HAART group P = 0.001. Duration of HAART was correlated with VL suppression, with maximum benefit seen after ≥12 weeks of therapy (odds ratio [OR]: 2.51; 95% confidence interval [CI]: 1.72-3.65). CD4+ cell count near delivery (OR: 1.53; 95% CI: 1.06-2.20) and baseline VL (OR: 0.74; 95% CI: 0.58-0.94) were also independently associated with VL suppression. Overall MTCT rate was 1.6%. HAART for ≥12 weeks, baseline VL and CD4 cell count near delivery were independently associated with viral suppression near delivery.

Authors+Show Affiliations

Department of Infectious Diseases, Hospital dos Servidores do Estado, Rio de Janeiro, Brazil. esau@uninet.com.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22362687

Citation

Joao, E C., et al. "Factors Associated With Viral Load Suppression in HIV-infected Pregnant Women in Rio De Janeiro, Brazil." International Journal of STD & AIDS, vol. 23, no. 1, 2012, pp. 44-7.
Joao EC, Gouvêa MI, Menezes JA, et al. Factors associated with viral load suppression in HIV-infected pregnant women in Rio de Janeiro, Brazil. Int J STD AIDS. 2012;23(1):44-7.
Joao, E. C., Gouvêa, M. I., Menezes, J. A., Sidi, L. C., Cruz, M. L., Berardo, P. T., Ceci, L., Cardoso, C. A., Teixeira, M. d. e. . L., Calvet, G. A., & Matos, H. J. (2012). Factors associated with viral load suppression in HIV-infected pregnant women in Rio de Janeiro, Brazil. International Journal of STD & AIDS, 23(1), 44-7. https://doi.org/10.1258/ijsa.2011.010545
Joao EC, et al. Factors Associated With Viral Load Suppression in HIV-infected Pregnant Women in Rio De Janeiro, Brazil. Int J STD AIDS. 2012;23(1):44-7. PubMed PMID: 22362687.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factors associated with viral load suppression in HIV-infected pregnant women in Rio de Janeiro, Brazil. AU - Joao,E C, AU - Gouvêa,M I, AU - Menezes,J A, AU - Sidi,L C, AU - Cruz,M L S, AU - Berardo,P T, AU - Ceci,L, AU - Cardoso,C A, AU - Teixeira,M de L B, AU - Calvet,G A, AU - Matos,H J, PY - 2012/2/25/entrez PY - 2012/3/1/pubmed PY - 2012/6/28/medline SP - 44 EP - 7 JF - International journal of STD & AIDS JO - Int J STD AIDS VL - 23 IS - 1 N2 - Viral load (VL) near delivery is a determinant of mother-to-child transmission (MTCT) of HIV. To evaluate factors associated with an undetectable VL near delivery in HIV-infected pregnant women receiving highly active antiretroviral therapy (HAART) and non-HAART regimens, HIV-infected pregnant women with a detectable VL at entry and having used antiretrovirals for ≥4 weeks before delivery were selected. Multivariate analysis was employed using binary logistic unconditional models; the dependent variable was having a VL <400 copies/mL near delivery. VL suppression was achieved in 403/707 women (57%): 65.4% in the HAART group, but only 26% in the non-HAART group P = 0.001. Duration of HAART was correlated with VL suppression, with maximum benefit seen after ≥12 weeks of therapy (odds ratio [OR]: 2.51; 95% confidence interval [CI]: 1.72-3.65). CD4+ cell count near delivery (OR: 1.53; 95% CI: 1.06-2.20) and baseline VL (OR: 0.74; 95% CI: 0.58-0.94) were also independently associated with VL suppression. Overall MTCT rate was 1.6%. HAART for ≥12 weeks, baseline VL and CD4 cell count near delivery were independently associated with viral suppression near delivery. SN - 1758-1052 UR - https://www.unboundmedicine.com/medline/citation/22362687/Factors_associated_with_viral_load_suppression_in_HIV_infected_pregnant_women_in_Rio_de_Janeiro_Brazil_ L2 - https://journals.sagepub.com/doi/10.1258/ijsa.2011.010545?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -