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Otologic and audiologic features of ethnic Chinese patients with Turner syndrome in Taiwan.
J Formos Med Assoc. 2012 Feb; 111(2):94-100.JF

Abstract

BACKGROUND/PURPOSE

Otologic and audiologic characteristics of Turner syndrome (TS) have been well documented in Caucasian-but not in Asian-populations. We report these features and possible causative factors for hearing loss in ethnic Chinese TS patients in Taiwan.

METHODS

The study was a cross-sectional trial that analyzed patients diagnosed with TS. We enrolled patients for otologic evaluations and age-appropriate pure tone audiometry. To explore the potential associations with hearing loss, we studied patient karyotype, history of recurrent otitis media (OM) and various craniofacial anomalies.

RESULTS

The 46 patients (mean age 17.3 years, range 5-34 years) enrolled, 22 (47.8%) had a history of recurrent OM. Otoscopic examination identified eardrum abnormalities in 45.6% of patients with myringosclerosis as the most common condition. A total of 21.7% patients showed auricular anomalies. Audiologic analysis revealed five cases (10.7%) with conductive hearing loss (CHL) and eight cases (17.4%) with sensorineural hearing loss (SNHL). Among patients with a history of recurrent OM, CHL prevailed (p = 0.0192) over SNHL (p = 0.1278). Karyotype and craniofacial anomalies were not associated with CHL or SNHL (p > 0.05).

CONCLUSION

We found varying degrees of otologic and audiologic abnormalities among the TS in ethnic Chinese population. About one-half of the patients had recurrent OM, which was more likely to be associated with CHL in early life. Therefore, regular surveillance, early diagnosis, and the initiation of appropriate treatment are crucial in improving the hearing and speech in children with TS as well as in preventing short- and long-term associated complications.

Authors+Show Affiliations

Division of Otology, Department of Otolaryngology Head and Neck Surgery, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22370288

Citation

Chan, Kai-Chieh, et al. "Otologic and Audiologic Features of Ethnic Chinese Patients With Turner Syndrome in Taiwan." Journal of the Formosan Medical Association = Taiwan Yi Zhi, vol. 111, no. 2, 2012, pp. 94-100.
Chan KC, Wang PC, Wu CM, et al. Otologic and audiologic features of ethnic Chinese patients with Turner syndrome in Taiwan. J Formos Med Assoc. 2012;111(2):94-100.
Chan, K. C., Wang, P. C., Wu, C. M., Ho, W. L., & Lo, F. S. (2012). Otologic and audiologic features of ethnic Chinese patients with Turner syndrome in Taiwan. Journal of the Formosan Medical Association = Taiwan Yi Zhi, 111(2), 94-100. https://doi.org/10.1016/j.jfma.2010.11.001
Chan KC, et al. Otologic and Audiologic Features of Ethnic Chinese Patients With Turner Syndrome in Taiwan. J Formos Med Assoc. 2012;111(2):94-100. PubMed PMID: 22370288.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Otologic and audiologic features of ethnic Chinese patients with Turner syndrome in Taiwan. AU - Chan,Kai-Chieh, AU - Wang,Pa-Chun, AU - Wu,Che-Ming, AU - Ho,Wan-Ling, AU - Lo,Fu-Sung, Y1 - 2012/02/08/ PY - 2010/08/26/received PY - 2010/11/14/revised PY - 2010/11/22/accepted PY - 2012/2/29/entrez PY - 2012/3/1/pubmed PY - 2012/7/28/medline SP - 94 EP - 100 JF - Journal of the Formosan Medical Association = Taiwan yi zhi JO - J Formos Med Assoc VL - 111 IS - 2 N2 - BACKGROUND/PURPOSE: Otologic and audiologic characteristics of Turner syndrome (TS) have been well documented in Caucasian-but not in Asian-populations. We report these features and possible causative factors for hearing loss in ethnic Chinese TS patients in Taiwan. METHODS: The study was a cross-sectional trial that analyzed patients diagnosed with TS. We enrolled patients for otologic evaluations and age-appropriate pure tone audiometry. To explore the potential associations with hearing loss, we studied patient karyotype, history of recurrent otitis media (OM) and various craniofacial anomalies. RESULTS: The 46 patients (mean age 17.3 years, range 5-34 years) enrolled, 22 (47.8%) had a history of recurrent OM. Otoscopic examination identified eardrum abnormalities in 45.6% of patients with myringosclerosis as the most common condition. A total of 21.7% patients showed auricular anomalies. Audiologic analysis revealed five cases (10.7%) with conductive hearing loss (CHL) and eight cases (17.4%) with sensorineural hearing loss (SNHL). Among patients with a history of recurrent OM, CHL prevailed (p = 0.0192) over SNHL (p = 0.1278). Karyotype and craniofacial anomalies were not associated with CHL or SNHL (p > 0.05). CONCLUSION: We found varying degrees of otologic and audiologic abnormalities among the TS in ethnic Chinese population. About one-half of the patients had recurrent OM, which was more likely to be associated with CHL in early life. Therefore, regular surveillance, early diagnosis, and the initiation of appropriate treatment are crucial in improving the hearing and speech in children with TS as well as in preventing short- and long-term associated complications. SN - 0929-6646 UR - https://www.unboundmedicine.com/medline/citation/22370288/Otologic_and_audiologic_features_of_ethnic_Chinese_patients_with_Turner_syndrome_in_Taiwan_ DB - PRIME DP - Unbound Medicine ER -