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The neuroprotective and lifespan-extension activities of Damnacanthus officinarum extracts in Caenorhabditis elegans.
J Ethnopharmacol 2012; 141(1):41-7JE

Abstract

AIM OF THE STUDY

This study was aimed to evaluate the neuroprotective and anti-aging activity of extracts in Caenorhabditis elegans from the roots and leaves of Damnacanthus officinarum Huang to provide the pharmacological basis in traditional medicine.

MATERIALS AND METHODS

Investigations on the neuroprotective and lifespan activity were carried out, which were observed by utilizing the following models: observing the worms' chemosensory behavior test based on the aversion index in the assay plate, neuroprotective activity of nematode by evaluating the ASH neuron survival and lifespan test in C. elegans.

RESULTS

It has been shown that the ethanol, n-butanol and aqueous extracts in the roots possessed significantly neuroprotective effect both in chemosensory behavior test and ASH neuron survival model. The same extracts in the leaves showed similar activities in two models, but have less potency revealing by the data. Four candidate extracts, possessing excellent neuroprotective activity, extend lifespan in C. elegans. The n-butanol extracts in the root part showed best efficacy among them.

CONCLUSION

The results show the n-butanol and aqueous extracts are the major pharmacological plant extracts. Moreover, the neuroprotective and lifespan-extension activity effects of root extracts are superior to leave extracts, supporting the traditional application of above-ground parts of DOH in treating various diseases associated with brain disorders and anti-aging.

Authors+Show Affiliations

Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji School of Pharmacy, Huazhong University of Science and Technology, Wuhan, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22370553

Citation

Yang, Xiliang, et al. "The Neuroprotective and Lifespan-extension Activities of Damnacanthus Officinarum Extracts in Caenorhabditis Elegans." Journal of Ethnopharmacology, vol. 141, no. 1, 2012, pp. 41-7.
Yang X, Zhang P, Wu J, et al. The neuroprotective and lifespan-extension activities of Damnacanthus officinarum extracts in Caenorhabditis elegans. J Ethnopharmacol. 2012;141(1):41-7.
Yang, X., Zhang, P., Wu, J., Xiong, S., Jin, N., & Huang, Z. (2012). The neuroprotective and lifespan-extension activities of Damnacanthus officinarum extracts in Caenorhabditis elegans. Journal of Ethnopharmacology, 141(1), pp. 41-7. doi:10.1016/j.jep.2012.01.025.
Yang X, et al. The Neuroprotective and Lifespan-extension Activities of Damnacanthus Officinarum Extracts in Caenorhabditis Elegans. J Ethnopharmacol. 2012 May 7;141(1):41-7. PubMed PMID: 22370553.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The neuroprotective and lifespan-extension activities of Damnacanthus officinarum extracts in Caenorhabditis elegans. AU - Yang,Xiliang, AU - Zhang,Peng, AU - Wu,Jizhou, AU - Xiong,Siqin, AU - Jin,Nanxiang, AU - Huang,Zebo, Y1 - 2012/02/20/ PY - 2011/08/10/received PY - 2011/12/21/revised PY - 2012/01/16/accepted PY - 2012/2/29/entrez PY - 2012/3/1/pubmed PY - 2012/8/11/medline SP - 41 EP - 7 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 141 IS - 1 N2 - AIM OF THE STUDY: This study was aimed to evaluate the neuroprotective and anti-aging activity of extracts in Caenorhabditis elegans from the roots and leaves of Damnacanthus officinarum Huang to provide the pharmacological basis in traditional medicine. MATERIALS AND METHODS: Investigations on the neuroprotective and lifespan activity were carried out, which were observed by utilizing the following models: observing the worms' chemosensory behavior test based on the aversion index in the assay plate, neuroprotective activity of nematode by evaluating the ASH neuron survival and lifespan test in C. elegans. RESULTS: It has been shown that the ethanol, n-butanol and aqueous extracts in the roots possessed significantly neuroprotective effect both in chemosensory behavior test and ASH neuron survival model. The same extracts in the leaves showed similar activities in two models, but have less potency revealing by the data. Four candidate extracts, possessing excellent neuroprotective activity, extend lifespan in C. elegans. The n-butanol extracts in the root part showed best efficacy among them. CONCLUSION: The results show the n-butanol and aqueous extracts are the major pharmacological plant extracts. Moreover, the neuroprotective and lifespan-extension activity effects of root extracts are superior to leave extracts, supporting the traditional application of above-ground parts of DOH in treating various diseases associated with brain disorders and anti-aging. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/22370553/The_neuroprotective_and_lifespan_extension_activities_of_Damnacanthus_officinarum_extracts_in_Caenorhabditis_elegans_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(12)00038-4 DB - PRIME DP - Unbound Medicine ER -