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Evaluation of serum creatinine- and cystatin C-based equations for the estimation of glomerular filtration rate in a Chinese population.
Scand J Urol Nephrol. 2012 Jun; 46(3):223-31.SJ

Abstract

OBJECTIVE

This study aimed to evaluate the applicability of a selection of glomerular filtration rate (GFR) estimating equations based on serum creatinine (SCr) and serum cystatin C in a Chinese population.

MATERIAL AND METHODS

Estimated GFR values from 10 equations were compared with reference GFR (rGFR) from the (99m)Tc-DTPA renal dynamic imaging method. The study enrolled 569 Chinese participants (41.5% women, 53.5 ± 16.9 years, range 19-92 years), with mean rGFR 74.80 ± 26.10 (range 9.8-146.8 ml/min/1.73 m(2)).

RESULTS

Bland-Altman analysis illustrated that the 95% agreement limits of all the equations surpassed the acceptable tolerance (<60 ml/min/1.73 m(2)), of which the MacIsaac equation was the closest one, reaching 71.7 ml/min/1.73 m(2). Linear regression analysis also demonstrated a consistent result. When assessed in all participants, the accuracy of the six equations reached and exceeded the acceptable level (≥70%), of which the Shanghai and MacIsaac equations gained more accuracy than others. When compared in subgroups, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), MacIsaac and Cockcroft-Gault (CG) equations were optimal for rGFR stages ≥ 90 ml/min/1.73 m(2), 30-89 ml/min/1.73 m(2) and < 30 ml/min/1.73 m(2), respectively.

CONCLUSION

The results demonstrated that further improvement is needed for the selected 10 equations. Not all the cystatin C equations were superior to SCr equations. They have their own applicability at various GFR levels. At present, the CKD-EPI, MacIsaac and CG equations may be applied to evaluate GFR in normal, mild to moderate and severe kidney function, respectively.

Authors+Show Affiliations

Division of Nephrology, Department of Geriatrics, School of Public Health, Nanjing Medical University, Nanjing, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Validation Study

Language

eng

PubMed ID

22376289

Citation

Pei, Xiao-Hua, et al. "Evaluation of Serum Creatinine- and Cystatin C-based Equations for the Estimation of Glomerular Filtration Rate in a Chinese Population." Scandinavian Journal of Urology and Nephrology, vol. 46, no. 3, 2012, pp. 223-31.
Pei XH, He J, Liu Q, et al. Evaluation of serum creatinine- and cystatin C-based equations for the estimation of glomerular filtration rate in a Chinese population. Scand J Urol Nephrol. 2012;46(3):223-31.
Pei, X. H., He, J., Liu, Q., Zhu, B., Bao, L. H., Yan, C. J., Wu, J. Q., & Zhao, W. H. (2012). Evaluation of serum creatinine- and cystatin C-based equations for the estimation of glomerular filtration rate in a Chinese population. Scandinavian Journal of Urology and Nephrology, 46(3), 223-31. https://doi.org/10.3109/00365599.2012.660985
Pei XH, et al. Evaluation of Serum Creatinine- and Cystatin C-based Equations for the Estimation of Glomerular Filtration Rate in a Chinese Population. Scand J Urol Nephrol. 2012;46(3):223-31. PubMed PMID: 22376289.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of serum creatinine- and cystatin C-based equations for the estimation of glomerular filtration rate in a Chinese population. AU - Pei,Xiao-Hua, AU - He,Juan, AU - Liu,Qiao, AU - Zhu,Bei, AU - Bao,Li-Hua, AU - Yan,Chen-Jing, AU - Wu,Jian-Qing, AU - Zhao,Wei-Hong, Y1 - 2012/03/01/ PY - 2012/3/2/entrez PY - 2012/3/2/pubmed PY - 2012/9/1/medline SP - 223 EP - 31 JF - Scandinavian journal of urology and nephrology JO - Scand J Urol Nephrol VL - 46 IS - 3 N2 - OBJECTIVE: This study aimed to evaluate the applicability of a selection of glomerular filtration rate (GFR) estimating equations based on serum creatinine (SCr) and serum cystatin C in a Chinese population. MATERIAL AND METHODS: Estimated GFR values from 10 equations were compared with reference GFR (rGFR) from the (99m)Tc-DTPA renal dynamic imaging method. The study enrolled 569 Chinese participants (41.5% women, 53.5 ± 16.9 years, range 19-92 years), with mean rGFR 74.80 ± 26.10 (range 9.8-146.8 ml/min/1.73 m(2)). RESULTS: Bland-Altman analysis illustrated that the 95% agreement limits of all the equations surpassed the acceptable tolerance (<60 ml/min/1.73 m(2)), of which the MacIsaac equation was the closest one, reaching 71.7 ml/min/1.73 m(2). Linear regression analysis also demonstrated a consistent result. When assessed in all participants, the accuracy of the six equations reached and exceeded the acceptable level (≥70%), of which the Shanghai and MacIsaac equations gained more accuracy than others. When compared in subgroups, the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), MacIsaac and Cockcroft-Gault (CG) equations were optimal for rGFR stages ≥ 90 ml/min/1.73 m(2), 30-89 ml/min/1.73 m(2) and < 30 ml/min/1.73 m(2), respectively. CONCLUSION: The results demonstrated that further improvement is needed for the selected 10 equations. Not all the cystatin C equations were superior to SCr equations. They have their own applicability at various GFR levels. At present, the CKD-EPI, MacIsaac and CG equations may be applied to evaluate GFR in normal, mild to moderate and severe kidney function, respectively. SN - 1651-2065 UR - https://www.unboundmedicine.com/medline/citation/22376289/Evaluation_of_serum_creatinine__and_cystatin_C_based_equations_for_the_estimation_of_glomerular_filtration_rate_in_a_Chinese_population_ L2 - https://www.tandfonline.com/doi/full/10.3109/00365599.2012.660985 DB - PRIME DP - Unbound Medicine ER -