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Deficient long-term response to pandemic vaccine results in an insufficient antibody response to seasonal influenza vaccination in solid organ transplant recipients.
Transplantation. 2012 Apr 27; 93(8):847-54.T

Abstract

BACKGROUND

Little is known about the long-term antibody response to the 2009-H1N1 vaccine in solid organ transplant recipients (SOTR) and its clinical repercussion on the efficacy of following 2010-2011 influenza vaccine.

METHODS

We performed a multicenter prospective study in SOTR receiving one dose of the nonadjuvant 2010-2011 seasonal influenza vaccine and determined the immunological response at 5 weeks after vaccination.

RESULTS

One hundred SOTR were included. Long-term antibody titers to the previous vaccine were only detected in one third of the patients. Patients with baseline titers had significantly higher seroprotection for the 2009-H1N1 strain (100% vs. 73%, relative risks [RR] 1.37, 95% confidence intervals [CI] 1.19-1.57; P=0.006), for H3N2 strain (100% vs. 62.2%, RR 1.61, 95% CI 1.36-1.90; P=0.005), and for B strain (100% vs. 69%; P=0.02). The seroconversion rate in patients with baseline titers was 90.9% vs. 73% (RR 2.97, 95% CI 0.75-11.74; P=0.07) for the 2009-H1N1 strain, 92.2% vs. 62.2% (RR 5.29, 95% CI 0.8-35.7; P=0.02) for the H3N2 strain, and 58.3% vs. 69% (P=0.45) for the B strain.

CONCLUSIONS

SOTR response to the 2010-2011 influenza vaccine was not optimal. The response was related to baseline titers; however, most of the patients did not exhibit detectable antibodies at vaccination lacking long-term response. New strategies are necessary to improve vaccination efficacy.

Authors+Show Affiliations

Instituto de Biomedicina de Sevilla (IBiS), University Hospital Virgen del Rocio/CSIC/University of Sevilla. Unit of Infectious Diseases, Microbiology and Preventive Medicine, Sevilla, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22377789

Citation

Cordero, Elisa, et al. "Deficient Long-term Response to Pandemic Vaccine Results in an Insufficient Antibody Response to Seasonal Influenza Vaccination in Solid Organ Transplant Recipients." Transplantation, vol. 93, no. 8, 2012, pp. 847-54.
Cordero E, Aydillo TA, Perez-Ordoñez A, et al. Deficient long-term response to pandemic vaccine results in an insufficient antibody response to seasonal influenza vaccination in solid organ transplant recipients. Transplantation. 2012;93(8):847-54.
Cordero, E., Aydillo, T. A., Perez-Ordoñez, A., Torre-Cisneros, J., Lara, R., Segura, C., Gentil, M. A., Gomez-Bravo, M. A., Lage, E., Pachon, J., & Perez-Romero, P. (2012). Deficient long-term response to pandemic vaccine results in an insufficient antibody response to seasonal influenza vaccination in solid organ transplant recipients. Transplantation, 93(8), 847-54. https://doi.org/10.1097/TP.0b013e318247a6ef
Cordero E, et al. Deficient Long-term Response to Pandemic Vaccine Results in an Insufficient Antibody Response to Seasonal Influenza Vaccination in Solid Organ Transplant Recipients. Transplantation. 2012 Apr 27;93(8):847-54. PubMed PMID: 22377789.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Deficient long-term response to pandemic vaccine results in an insufficient antibody response to seasonal influenza vaccination in solid organ transplant recipients. AU - Cordero,Elisa, AU - Aydillo,Teresa A, AU - Perez-Ordoñez,Ana, AU - Torre-Cisneros,Julian, AU - Lara,Rosario, AU - Segura,Carmen, AU - Gentil,Miguel A, AU - Gomez-Bravo,Miguel A, AU - Lage,Ernesto, AU - Pachon,Jeronimo, AU - Perez-Romero,Pilar, PY - 2012/3/2/entrez PY - 2012/3/2/pubmed PY - 2012/6/5/medline SP - 847 EP - 54 JF - Transplantation JO - Transplantation VL - 93 IS - 8 N2 - BACKGROUND: Little is known about the long-term antibody response to the 2009-H1N1 vaccine in solid organ transplant recipients (SOTR) and its clinical repercussion on the efficacy of following 2010-2011 influenza vaccine. METHODS: We performed a multicenter prospective study in SOTR receiving one dose of the nonadjuvant 2010-2011 seasonal influenza vaccine and determined the immunological response at 5 weeks after vaccination. RESULTS: One hundred SOTR were included. Long-term antibody titers to the previous vaccine were only detected in one third of the patients. Patients with baseline titers had significantly higher seroprotection for the 2009-H1N1 strain (100% vs. 73%, relative risks [RR] 1.37, 95% confidence intervals [CI] 1.19-1.57; P=0.006), for H3N2 strain (100% vs. 62.2%, RR 1.61, 95% CI 1.36-1.90; P=0.005), and for B strain (100% vs. 69%; P=0.02). The seroconversion rate in patients with baseline titers was 90.9% vs. 73% (RR 2.97, 95% CI 0.75-11.74; P=0.07) for the 2009-H1N1 strain, 92.2% vs. 62.2% (RR 5.29, 95% CI 0.8-35.7; P=0.02) for the H3N2 strain, and 58.3% vs. 69% (P=0.45) for the B strain. CONCLUSIONS: SOTR response to the 2010-2011 influenza vaccine was not optimal. The response was related to baseline titers; however, most of the patients did not exhibit detectable antibodies at vaccination lacking long-term response. New strategies are necessary to improve vaccination efficacy. SN - 1534-6080 UR - https://www.unboundmedicine.com/medline/citation/22377789/Deficient_long_term_response_to_pandemic_vaccine_results_in_an_insufficient_antibody_response_to_seasonal_influenza_vaccination_in_solid_organ_transplant_recipients_ L2 - https://doi.org/10.1097/TP.0b013e318247a6ef DB - PRIME DP - Unbound Medicine ER -