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Chemoprevention with green propolis green propolis extracted in L-lysine versus carcinogenesis promotion with L-lysine in N-Butyl-N-[4-hydroxybutyl] nitrosamine (BBN) induced rat bladder cancer.

Abstract

PURPOSE

To determine the effects of green propolis extracted in L-lysine (WSDP) and of L- lysine for 40 weeks on induced rat bladder carcinogenesis.

METHODS

The animals (groups I, II, III, IV, V and VI) received BBN during 14 weeks. Group I was treated with propolis 30 days prior received BBN, and then these animals were treated daily with propolis; Groups II and III was treated with subcutaneous and oral propolis (respectively) concurrently with BBN. The animals of Group IV were treated L-lysine; Group V received water subcutaneous; and Group VI received only to BBN. Among the animals not submitted to carcinogenesis induction, Group VII received propolis, Group VIII received L-lysine and Group IX received water.

RESULTS

The carcinoma incidence in Group I was lower than that of control (Group VI). The carcinoma multiplicity in Group IV was greater than in Group VI. All animals treated with L-lysine developed carcinomas, and they were also more invasive in Group IV than in controls. On the other hand, Group VIII showed no bladder lesions.

CONCLUSION

The WSDP is chemopreventive against rat bladder carcinogenesis, if administered 30 days prior to BBN , and that L-lysine causes promotion of bladder carcinogenesis.

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  • Authors+Show Affiliations

    ,

    Department of Pathology, UFC, Ceara, Brazil. eusoucondor@yahoo.com.br

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    Source

    MeSH

    Animals
    Anticarcinogenic Agents
    Butylhydroxybutylnitrosamine
    Carcinogens
    Female
    Lysine
    Plant Extracts
    Propolis
    Rats
    Rats, Wistar
    Time Factors
    Treatment Outcome
    Urinary Bladder Neoplasms

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    22378376

    Citation

    TY - JOUR T1 - Chemoprevention with green propolis green propolis extracted in L-lysine versus carcinogenesis promotion with L-lysine in N-Butyl-N-[4-hydroxybutyl] nitrosamine (BBN) induced rat bladder cancer. AU - Dornelas,Conceição Aparecida, AU - Fechine-Jamacaru,Francisco Vagnaldo, AU - Albuquerque,Irineu Lima, AU - Magalhães,Hemerson Iury Ferreira, AU - Souza,Adjair Jairo Silva de, AU - Alves,Leonardo Alcântara, AU - Almeida,Paulo Roberto Carvalho de, AU - Lemos,Telma Leda Gomes de, AU - Castro,José Daniel Vieira de, AU - Moraes,Maria Elisabete Amaral, AU - Moraes,Manoel Odorico, PY - 2011/9/21/received PY - 2011/12/20/accepted PY - 2012/3/2/entrez PY - 2012/3/2/pubmed PY - 2013/1/5/medline SP - 185 EP - 92 JF - Acta cirúrgica brasileira / Sociedade Brasileira para Desenvolvimento Pesquisa em Cirurgia JO - Acta Cir Bras VL - 27 IS - 2 N2 - PURPOSE: To determine the effects of green propolis extracted in L-lysine (WSDP) and of L- lysine for 40 weeks on induced rat bladder carcinogenesis. METHODS: The animals (groups I, II, III, IV, V and VI) received BBN during 14 weeks. Group I was treated with propolis 30 days prior received BBN, and then these animals were treated daily with propolis; Groups II and III was treated with subcutaneous and oral propolis (respectively) concurrently with BBN. The animals of Group IV were treated L-lysine; Group V received water subcutaneous; and Group VI received only to BBN. Among the animals not submitted to carcinogenesis induction, Group VII received propolis, Group VIII received L-lysine and Group IX received water. RESULTS: The carcinoma incidence in Group I was lower than that of control (Group VI). The carcinoma multiplicity in Group IV was greater than in Group VI. All animals treated with L-lysine developed carcinomas, and they were also more invasive in Group IV than in controls. On the other hand, Group VIII showed no bladder lesions. CONCLUSION: The WSDP is chemopreventive against rat bladder carcinogenesis, if administered 30 days prior to BBN , and that L-lysine causes promotion of bladder carcinogenesis. SN - 1678-2674 UR - https://www.unboundmedicine.com/medline/citation/22378376/Chemoprevention_with_green_propolis_green_propolis_extracted_in_L_lysine_versus_carcinogenesis_promotion_with_L_lysine_in_N_Butyl_N_[4_hydroxybutyl]_nitrosamine__BBN__induced_rat_bladder_cancer_ L2 - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502012000200015&lng=en&nrm=iso&tlng=en ER -