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Modulation of the association between plasma intercellular adhesion molecule-1 and cancer risk by n-3 PUFA intake: a nested case-control study.
Am J Clin Nutr. 2012 Apr; 95(4):944-50.AJ

Abstract

BACKGROUND

Mechanistic data suggest that n-3 PUFAs and endothelial function may interact and play a role in carcinogenesis, but epidemiologic evidence is lacking.

OBJECTIVE

Our objective was to investigate whether the prospective association between soluble intercellular adhesion molecule-1 (sICAM-1) and cancer risk is modulated by n-3 PUFA intake.

DESIGN

A nested case-control study was designed to include all first-incident cancer cases diagnosed in the SUpplémentation en VItamines et Minéraux AntioXydants cohort between 1994 and 2007, with available dietary data from 24-h records (n = 408). Cases were matched with 1 or 2 randomly selected controls (n = 760). Conditional logistic regression was used to estimate ORs and 95% CIs for the association between prediagnostic plasma concentrations of sICAM-1 and cancer risk, stratified by n-3 PUFA intake. The interactions between sICAM-1 and n-3 PUFA intake were tested.

RESULTS

An interaction was observed between sICAM-1 and n-3 PUFA intake, which was consistent across the studied cancer locations (P-interaction = 0.036 for overall, 0.038 for breast, and 0.020 for prostate cancer risk). sICAM-1 concentrations were positively associated with cancer risk among subjects with n-3 PUFA intakes below the median (multivariate OR(Tertile3vsTertile1): 2.8; 95% CI: 1.5, 5.2; P-trend = 0.001), whereas this association was not observed for subjects with n-3 PUFA intakes above the median (OR(Tertile3vsTertile1): 1.3; 95% CI: 0.8, 2.3; P-trend = 0.3).

CONCLUSION

These findings suggest that n-3 PUFA intake may counteract the procarcinogenic actions of sICAM-1.

Authors+Show Affiliations

INSERM U557, National Institute of Health and Medical Research, Inra, Cnam, Paris 13 University, Bobigny, France. m.touvier@uren.smbh.univ-paris13.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22378736

Citation

Touvier, Mathilde, et al. "Modulation of the Association Between Plasma Intercellular Adhesion Molecule-1 and Cancer Risk By N-3 PUFA Intake: a Nested Case-control Study." The American Journal of Clinical Nutrition, vol. 95, no. 4, 2012, pp. 944-50.
Touvier M, Kesse-Guyot E, Andreeva VA, et al. Modulation of the association between plasma intercellular adhesion molecule-1 and cancer risk by n-3 PUFA intake: a nested case-control study. Am J Clin Nutr. 2012;95(4):944-50.
Touvier, M., Kesse-Guyot, E., Andreeva, V. A., Fezeu, L., Charnaux, N., Sutton, A., Druesne-Pecollo, N., Hercberg, S., Galan, P., Zelek, L., Latino-Martel, P., & Czernichow, S. (2012). Modulation of the association between plasma intercellular adhesion molecule-1 and cancer risk by n-3 PUFA intake: a nested case-control study. The American Journal of Clinical Nutrition, 95(4), 944-50. https://doi.org/10.3945/ajcn.111.027805
Touvier M, et al. Modulation of the Association Between Plasma Intercellular Adhesion Molecule-1 and Cancer Risk By N-3 PUFA Intake: a Nested Case-control Study. Am J Clin Nutr. 2012;95(4):944-50. PubMed PMID: 22378736.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulation of the association between plasma intercellular adhesion molecule-1 and cancer risk by n-3 PUFA intake: a nested case-control study. AU - Touvier,Mathilde, AU - Kesse-Guyot,Emmanuelle, AU - Andreeva,Valentina A, AU - Fezeu,Léopold, AU - Charnaux,Nathalie, AU - Sutton,Angela, AU - Druesne-Pecollo,Nathalie, AU - Hercberg,Serge, AU - Galan,Pilar, AU - Zelek,Laurent, AU - Latino-Martel,Paule, AU - Czernichow,Sébastien, Y1 - 2012/02/29/ PY - 2012/3/2/entrez PY - 2012/3/2/pubmed PY - 2012/5/9/medline SP - 944 EP - 50 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 95 IS - 4 N2 - BACKGROUND: Mechanistic data suggest that n-3 PUFAs and endothelial function may interact and play a role in carcinogenesis, but epidemiologic evidence is lacking. OBJECTIVE: Our objective was to investigate whether the prospective association between soluble intercellular adhesion molecule-1 (sICAM-1) and cancer risk is modulated by n-3 PUFA intake. DESIGN: A nested case-control study was designed to include all first-incident cancer cases diagnosed in the SUpplémentation en VItamines et Minéraux AntioXydants cohort between 1994 and 2007, with available dietary data from 24-h records (n = 408). Cases were matched with 1 or 2 randomly selected controls (n = 760). Conditional logistic regression was used to estimate ORs and 95% CIs for the association between prediagnostic plasma concentrations of sICAM-1 and cancer risk, stratified by n-3 PUFA intake. The interactions between sICAM-1 and n-3 PUFA intake were tested. RESULTS: An interaction was observed between sICAM-1 and n-3 PUFA intake, which was consistent across the studied cancer locations (P-interaction = 0.036 for overall, 0.038 for breast, and 0.020 for prostate cancer risk). sICAM-1 concentrations were positively associated with cancer risk among subjects with n-3 PUFA intakes below the median (multivariate OR(Tertile3vsTertile1): 2.8; 95% CI: 1.5, 5.2; P-trend = 0.001), whereas this association was not observed for subjects with n-3 PUFA intakes above the median (OR(Tertile3vsTertile1): 1.3; 95% CI: 0.8, 2.3; P-trend = 0.3). CONCLUSION: These findings suggest that n-3 PUFA intake may counteract the procarcinogenic actions of sICAM-1. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/22378736/Modulation_of_the_association_between_plasma_intercellular_adhesion_molecule_1_and_cancer_risk_by_n_3_PUFA_intake:_a_nested_case_control_study_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.111.027805 DB - PRIME DP - Unbound Medicine ER -