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Idiopathic transverse myelitis and neuromyelitis optica: clinical profiles, pathophysiology and therapeutic choices.
Curr Neuropharmacol. 2011 Sep; 9(3):417-28.CN

Abstract

Transverse myelitis is a focal inflammatory disorder of the spinal cord which may arise due to different etiologies. Transverse myelitis may be idiopathic or related/secondary to other diseases including infections, connective tissue disorders and other autoimmune diseases. It may be also associated with optic neuritis (neuromyelitis optica), which may precede transverse myelitis. In this manuscript we review the pathophysiology of different types of transverse myelitis and neuromyelitis optica and discuss diagnostic criteria for idiopathic transverse myelitis and risk of development of multiple sclerosis after an episode of transverse myelitis. We also discuss treatment options including corticosteroids, immunosuppressives and monoclonal antibodies, plasma exchange and intravenous immunoglobulins.

Authors+Show Affiliations

Department of Neurology, Case Western Reserve University, Cleveland, OH, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22379456

Citation

Awad, Amer, and Olaf Stüve. "Idiopathic Transverse Myelitis and Neuromyelitis Optica: Clinical Profiles, Pathophysiology and Therapeutic Choices." Current Neuropharmacology, vol. 9, no. 3, 2011, pp. 417-28.
Awad A, Stüve O. Idiopathic transverse myelitis and neuromyelitis optica: clinical profiles, pathophysiology and therapeutic choices. Curr Neuropharmacol. 2011;9(3):417-28.
Awad, A., & Stüve, O. (2011). Idiopathic transverse myelitis and neuromyelitis optica: clinical profiles, pathophysiology and therapeutic choices. Current Neuropharmacology, 9(3), 417-28. https://doi.org/10.2174/157015911796557948
Awad A, Stüve O. Idiopathic Transverse Myelitis and Neuromyelitis Optica: Clinical Profiles, Pathophysiology and Therapeutic Choices. Curr Neuropharmacol. 2011;9(3):417-28. PubMed PMID: 22379456.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Idiopathic transverse myelitis and neuromyelitis optica: clinical profiles, pathophysiology and therapeutic choices. AU - Awad,Amer, AU - Stüve,Olaf, PY - 2010/03/20/received PY - 2010/04/18/revised PY - 2010/04/19/accepted PY - 2012/3/2/entrez PY - 2012/3/2/pubmed PY - 2012/3/2/medline KW - Transverse myelitis KW - epidemiology KW - neuromyelitis optica KW - pathogenesis KW - pathology KW - treatment. SP - 417 EP - 28 JF - Current neuropharmacology JO - Curr Neuropharmacol VL - 9 IS - 3 N2 - Transverse myelitis is a focal inflammatory disorder of the spinal cord which may arise due to different etiologies. Transverse myelitis may be idiopathic or related/secondary to other diseases including infections, connective tissue disorders and other autoimmune diseases. It may be also associated with optic neuritis (neuromyelitis optica), which may precede transverse myelitis. In this manuscript we review the pathophysiology of different types of transverse myelitis and neuromyelitis optica and discuss diagnostic criteria for idiopathic transverse myelitis and risk of development of multiple sclerosis after an episode of transverse myelitis. We also discuss treatment options including corticosteroids, immunosuppressives and monoclonal antibodies, plasma exchange and intravenous immunoglobulins. SN - 1875-6190 UR - https://www.unboundmedicine.com/medline/citation/22379456/Idiopathic_transverse_myelitis_and_neuromyelitis_optica:_clinical_profiles_pathophysiology_and_therapeutic_choices_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=1570-159X&volume=9&issue=3&spage=417&aulast=Awad DB - PRIME DP - Unbound Medicine ER -
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