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Evaluation of osteoarthritis in cats: novel information from a pilot study.
Vet Surg. 2012 Apr; 41(3):328-35.VS

Abstract

OBJECTIVE

To describe structural changes associated with osteoarthritis (OA) in cats and to quantify OA-associated disability using functional evaluations.

STUDY DESIGN

Cross-sectional pilot study with longitudinal data.

ANIMALS

Normal cats (n = 2) and coxofemoral joint OA cats (n = 4) were evaluated by physical examination, radiography, and magnetic resonance imaging (MRI).

METHODS

Structural changes related to OA were scored using computed radiographs (CR) and MRI. Functional evaluation consisted of podobarometric gait analyses performed using a pressure-sensitive mattress and motor activity assessments using collar-attached, accelerometer-based activity sensors.

RESULTS

Structural scores for the coxofemoral joint OA-related lesions were lower in normal cats than OA cats for MRI (P = .07). Use of MRI allowed for whole-organ assessment of the coxofemoral joint. Pelvic limb peak vertical ground reaction force (PVF) was higher in normal cats than OA cats (P = .10). During the night, motor activity was greater in normal cats than OA cats (P = .04). PVF was positively correlated with mean motor activity (Spearman coefficient [Rho] = 0.83, P = .04) and negatively correlated with age and MRI structural score (Rho = -0.93 and -0.79, P < .01 and .06, respectively).

CONCLUSIONS

This study provides the first description of OA-related lesions in cats using MRI. Gait analysis and accelerometry should be considered as objective tools to characterize OA-associated disability, although these assessments were weakly correlated with structural changes.

Authors+Show Affiliations

Groupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Québec, Canada.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

22380935

Citation

Guillot, Martin, et al. "Evaluation of Osteoarthritis in Cats: Novel Information From a Pilot Study." Veterinary Surgery : VS, vol. 41, no. 3, 2012, pp. 328-35.
Guillot M, Moreau M, d'Anjou MA, et al. Evaluation of osteoarthritis in cats: novel information from a pilot study. Vet Surg. 2012;41(3):328-35.
Guillot, M., Moreau, M., d'Anjou, M. A., Martel-Pelletier, J., Pelletier, J. P., & Troncy, E. (2012). Evaluation of osteoarthritis in cats: novel information from a pilot study. Veterinary Surgery : VS, 41(3), 328-35. https://doi.org/10.1111/j.1532-950X.2012.00976.x
Guillot M, et al. Evaluation of Osteoarthritis in Cats: Novel Information From a Pilot Study. Vet Surg. 2012;41(3):328-35. PubMed PMID: 22380935.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of osteoarthritis in cats: novel information from a pilot study. AU - Guillot,Martin, AU - Moreau,Maxim, AU - d'Anjou,Marc-André, AU - Martel-Pelletier,Johanne, AU - Pelletier,Jean-Pierre, AU - Troncy,Eric, Y1 - 2012/03/01/ PY - 2012/3/3/entrez PY - 2012/3/3/pubmed PY - 2013/7/3/medline SP - 328 EP - 35 JF - Veterinary surgery : VS JO - Vet Surg VL - 41 IS - 3 N2 - OBJECTIVE: To describe structural changes associated with osteoarthritis (OA) in cats and to quantify OA-associated disability using functional evaluations. STUDY DESIGN: Cross-sectional pilot study with longitudinal data. ANIMALS: Normal cats (n = 2) and coxofemoral joint OA cats (n = 4) were evaluated by physical examination, radiography, and magnetic resonance imaging (MRI). METHODS: Structural changes related to OA were scored using computed radiographs (CR) and MRI. Functional evaluation consisted of podobarometric gait analyses performed using a pressure-sensitive mattress and motor activity assessments using collar-attached, accelerometer-based activity sensors. RESULTS: Structural scores for the coxofemoral joint OA-related lesions were lower in normal cats than OA cats for MRI (P = .07). Use of MRI allowed for whole-organ assessment of the coxofemoral joint. Pelvic limb peak vertical ground reaction force (PVF) was higher in normal cats than OA cats (P = .10). During the night, motor activity was greater in normal cats than OA cats (P = .04). PVF was positively correlated with mean motor activity (Spearman coefficient [Rho] = 0.83, P = .04) and negatively correlated with age and MRI structural score (Rho = -0.93 and -0.79, P < .01 and .06, respectively). CONCLUSIONS: This study provides the first description of OA-related lesions in cats using MRI. Gait analysis and accelerometry should be considered as objective tools to characterize OA-associated disability, although these assessments were weakly correlated with structural changes. SN - 1532-950X UR - https://www.unboundmedicine.com/medline/citation/22380935/Evaluation_of_osteoarthritis_in_cats:_novel_information_from_a_pilot_study_ L2 - https://doi.org/10.1111/j.1532-950X.2012.00976.x DB - PRIME DP - Unbound Medicine ER -