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Evaluation of lipid peroxidation and erythrocyte glutathione peroxidase and superoxide dismutase in hemodialysis patients.
Saudi J Kidney Dis Transpl 2012; 23(2):274-9SJ

Abstract

Oxidative stress often occurs in chronic hemodialysis (HD). The aim of the present study was to determine plasma malondialdehyde (MDA) level for lipid peroxidation product and erythrocyte superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities as enzymatic antioxidants. Thirty-one HD patients (aged 50.3 ± 14.9 years) who were dialyzed three times per week and 31 healthy subjects (aged 47.8 ± 13.9 years) were enrolled. The results showed lower enzymatic antioxidants activity (GPx, SOD) and higher MDA levels in comparison with control subjects. In addition, SOD and GPx activities significantly decreased and MDA increased after HD. We also found that there was a significantly negative correlation between SOD and GPx with MDA. The results suggest that elevated level of plasma MDA and reduced activities of SOD and GPx can be caused oxidative stress, which may play a critical role in HD complications.

Authors+Show Affiliations

Department of Nutrition, Zahedan University of Medical Sciences, Zahedan, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22382218

Citation

Montazerifar, Farzaneh, et al. "Evaluation of Lipid Peroxidation and Erythrocyte Glutathione Peroxidase and Superoxide Dismutase in Hemodialysis Patients." Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia, vol. 23, no. 2, 2012, pp. 274-9.
Montazerifar F, Hashemi M, Karajibani M, et al. Evaluation of lipid peroxidation and erythrocyte glutathione peroxidase and superoxide dismutase in hemodialysis patients. Saudi J Kidney Dis Transpl. 2012;23(2):274-9.
Montazerifar, F., Hashemi, M., Karajibani, M., Sanadgol, H., & Dikshit, M. (2012). Evaluation of lipid peroxidation and erythrocyte glutathione peroxidase and superoxide dismutase in hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 23(2), pp. 274-9.
Montazerifar F, et al. Evaluation of Lipid Peroxidation and Erythrocyte Glutathione Peroxidase and Superoxide Dismutase in Hemodialysis Patients. Saudi J Kidney Dis Transpl. 2012;23(2):274-9. PubMed PMID: 22382218.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of lipid peroxidation and erythrocyte glutathione peroxidase and superoxide dismutase in hemodialysis patients. AU - Montazerifar,Farzaneh, AU - Hashemi,Mohammad, AU - Karajibani,Mansour, AU - Sanadgol,Houshang, AU - Dikshit,Madhurima, PY - 2012/3/3/entrez PY - 2012/3/3/pubmed PY - 2012/5/18/medline SP - 274 EP - 9 JF - Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia JO - Saudi J Kidney Dis Transpl VL - 23 IS - 2 N2 - Oxidative stress often occurs in chronic hemodialysis (HD). The aim of the present study was to determine plasma malondialdehyde (MDA) level for lipid peroxidation product and erythrocyte superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities as enzymatic antioxidants. Thirty-one HD patients (aged 50.3 ± 14.9 years) who were dialyzed three times per week and 31 healthy subjects (aged 47.8 ± 13.9 years) were enrolled. The results showed lower enzymatic antioxidants activity (GPx, SOD) and higher MDA levels in comparison with control subjects. In addition, SOD and GPx activities significantly decreased and MDA increased after HD. We also found that there was a significantly negative correlation between SOD and GPx with MDA. The results suggest that elevated level of plasma MDA and reduced activities of SOD and GPx can be caused oxidative stress, which may play a critical role in HD complications. SN - 1319-2442 UR - https://www.unboundmedicine.com/medline/citation/22382218/Evaluation_of_lipid_peroxidation_and_erythrocyte_glutathione_peroxidase_and_superoxide_dismutase_in_hemodialysis_patients_ L2 - http://www.sjkdt.org/article.asp?issn=1319-2442;year=2012;volume=23;issue=2;spage=274;epage=279;aulast=Montazerifar DB - PRIME DP - Unbound Medicine ER -