Tags

Type your tag names separated by a space and hit enter

Incidence of contrast-induced acute kidney injury associated with diagnostic or interventional coronary angiography.
J Nephrol 2012 Nov-Dec; 25(6):1098-107JN

Abstract

BACKGROUND

Contrast-induced acute kidney injury (CI-AKI) represents an important cause of hospital-acquired AKI. The aim of this study was to evaluate the incidence of CI-AKI after coronary angiography (CA) or percutaneous coronary intervention (PCI) and the role of patient-/procedure-related risk factors.

METHODS

For 11 months, patients undergoing CA or PCI were prospectively evaluated for CI-AKI, and factors possibly affecting CI-AKI were analyzed. Statistical analysis was completed using Student's t-test, chi-square or Fisher exact test, and multivariate logistic regression.

RESULTS

Among 585 consecutive patients, incidence of CI-AKI was 5.1% (n=30) and renal replacement therapy was required in 10% of those (n=3). Incidence of CI-AKI was higher in patients with anemia or chronic kidney disease (CKD) associated with diabetes. Basal hemoglobin was significantly lower in CI-AKI patients while Mehran score, contrast medium (CM) volume, contrast ratio (CM volume / maximum contrast dose) and ratio glomerular filtration rate (CM volume / GFR) were significantly higher. Multivariate analysis selected a higher contrast ratio as a factor independently associated with a higher risk of CI-AKI which otherwise appeared to be lower with increasing basal hemoglobin.

CONCLUSIONS

The incidence of CI-AKI after CA or PCI was higher in patients with CKD associated with diabetes. Lower levels of basal hemoglobin appeared to be related to a higher risk of CI-AKI, and contrast media volume, especially if exceeding the dose adjusted for renal function, was a strong modifiable risk factor for CI-AKI.

Authors+Show Affiliations

Department of Nephrology and Urology, Policlinico Umberto I, Sapienza University, Rome, Italy. santo.morabito@uniroma1.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

22383347

Citation

Morabito, Santo, et al. "Incidence of Contrast-induced Acute Kidney Injury Associated With Diagnostic or Interventional Coronary Angiography." Journal of Nephrology, vol. 25, no. 6, 2012, pp. 1098-107.
Morabito S, Pistolesi V, Benedetti G, et al. Incidence of contrast-induced acute kidney injury associated with diagnostic or interventional coronary angiography. J Nephrol. 2012;25(6):1098-107.
Morabito, S., Pistolesi, V., Benedetti, G., Di Roma, A., Colantonio, R., Mancone, M., ... Pierucci, A. (2012). Incidence of contrast-induced acute kidney injury associated with diagnostic or interventional coronary angiography. Journal of Nephrology, 25(6), pp. 1098-107. doi:10.5301/jn.5000101.
Morabito S, et al. Incidence of Contrast-induced Acute Kidney Injury Associated With Diagnostic or Interventional Coronary Angiography. J Nephrol. 2012;25(6):1098-107. PubMed PMID: 22383347.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incidence of contrast-induced acute kidney injury associated with diagnostic or interventional coronary angiography. AU - Morabito,Santo, AU - Pistolesi,Valentina, AU - Benedetti,Giulia, AU - Di Roma,Angelo, AU - Colantonio,Riccardo, AU - Mancone,Massimo, AU - Sardella,Gennaro, AU - Cibelli,Loredana, AU - Ambrosino,Mariacarmela, AU - Polistena,Francesca, AU - Pierucci,Alessandro, PY - 2011/12/27/accepted PY - 2012/3/3/entrez PY - 2012/3/3/pubmed PY - 2013/5/7/medline SP - 1098 EP - 107 JF - Journal of nephrology JO - J. Nephrol. VL - 25 IS - 6 N2 - BACKGROUND: Contrast-induced acute kidney injury (CI-AKI) represents an important cause of hospital-acquired AKI. The aim of this study was to evaluate the incidence of CI-AKI after coronary angiography (CA) or percutaneous coronary intervention (PCI) and the role of patient-/procedure-related risk factors. METHODS: For 11 months, patients undergoing CA or PCI were prospectively evaluated for CI-AKI, and factors possibly affecting CI-AKI were analyzed. Statistical analysis was completed using Student's t-test, chi-square or Fisher exact test, and multivariate logistic regression. RESULTS: Among 585 consecutive patients, incidence of CI-AKI was 5.1% (n=30) and renal replacement therapy was required in 10% of those (n=3). Incidence of CI-AKI was higher in patients with anemia or chronic kidney disease (CKD) associated with diabetes. Basal hemoglobin was significantly lower in CI-AKI patients while Mehran score, contrast medium (CM) volume, contrast ratio (CM volume / maximum contrast dose) and ratio glomerular filtration rate (CM volume / GFR) were significantly higher. Multivariate analysis selected a higher contrast ratio as a factor independently associated with a higher risk of CI-AKI which otherwise appeared to be lower with increasing basal hemoglobin. CONCLUSIONS: The incidence of CI-AKI after CA or PCI was higher in patients with CKD associated with diabetes. Lower levels of basal hemoglobin appeared to be related to a higher risk of CI-AKI, and contrast media volume, especially if exceeding the dose adjusted for renal function, was a strong modifiable risk factor for CI-AKI. SN - 1724-6059 UR - https://www.unboundmedicine.com/medline/citation/22383347/Incidence_of_contrast_induced_acute_kidney_injury_associated_with_diagnostic_or_interventional_coronary_angiography_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=22383347.ui DB - PRIME DP - Unbound Medicine ER -